Interactions between fecal gut microbiome, enteric pathogens, and energy regulating hormones among acutely malnourished rural Gambian children

Helen Nabwera; Josh L. Espinoza; Archibald Worwui; Modupeh Betts; Catherine Okoi; Abdul K. Sesay; Rowan Bancroft; Schadrac C. Agbla; Sheikh Jarju; Richard S. Bradbury; Mariama Colley; Amadou T. Jallow; Jie Liu; Eric R. Houpt; Andrew M. Prentice; Martin Antonio; Robin M. Bernstein; Christopher L. Dupont; Brenda Kwambana

doi:10.1016/j.ebiom.2021.103644

Interactions between fecal gut microbiome, enteric pathogens, and energy regulating hormones among acutely malnourished rural Gambian children

Helen Nabwera
, Josh L. Espinoza
, Archibald Worwui
, Modupeh Betts
, Catherine Okoi
, Abdul K. Sesay
, Rowan Bancroft
, Schadrac C. Agbla
, Sheikh Jarju
, Richard S. Bradbury
, Mariama Colley
, Amadou T. Jallow
, Jie Liu
, Eric R. Houpt
, Andrew M. Prentice
, Martin Antonio
, Robin M. Bernstein
, Christopher L. Dupont
, Brenda Kwambana

J. Craig Venture Institute
Durban University of Technology
London School of Hygiene and Tropical Medicine
University College London
University of Liverpool
Federation University
University of Virginia
University of Colorado Boulder

Research output: Contribution to journal › Article › peer-review

21 Citations (Scopus)

Abstract

Background

The specific roles that gut microbiota, known pathogens, and host energy-regulating hormones play in the pathogenesis of non-edematous severe acute malnutrition (marasmus SAM) and moderate acute malnutrition (MAM) during outpatient nutritional rehabilitation are yet to be explored.

Methods

We applied an ensemble of sample-specific (intra- and inter-modality) association networks to gain deeper insights into the pathogenesis of acute malnutrition and its severity among children under 5 years of age in rural Gambia, where marasmus SAM is most prevalent.

Findings

Children with marasmus SAM have distinct microbiome characteristics and biologically-relevant multimodal biomarkers not observed among children with moderate acute malnutrition. Marasmus SAM was characterized by lower microbial richness and biomass, significant enrichments in Enterobacteriaceae, altered interactions between specific Enterobacteriaceae and key energy regulating hormones and their receptors.

Interpretation

Our findings suggest that marasmus SAM is characterized by the collapse of a complex system with nested interactions and key associations between the gut microbiome, enteric pathogens, and energy regulating hormones. Further exploration of these systems will help inform innovative preventive and therapeutic interventions.

Original language	English
Article number	103644
Pages (from-to)	e103644
Journal	eBioMedicine
Volume	73
Early online date	22 Oct 2021
DOIs	https://doi.org/10.1016/j.ebiom.2021.103644
Publication status	Published - 1 Nov 2021

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 2 Zero Hunger

Keywords

Community detection
Enteric pathogens
Escherichia-Shigella
Feature selection
Gut microbiome
Malnutrition
Network analysis
West Africa

Access to Document

10.1016/j.ebiom.2021.103644Licence: CC BY

PIIS2352396421004370Final published version, 3.02 MBLicence: CC BY

Cite this

Nabwera, H., Espinoza, J. L., Worwui, A., Betts, M., Okoi, C., Sesay, A. K., Bancroft, R., Agbla, S. C., Jarju, S., Bradbury, R. S., Colley, M., Jallow, A. T., Liu, J., Houpt, E. R., Prentice, A. M., Antonio, M., Bernstein, R. M., Dupont, C. L., & Kwambana, B. (2021). Interactions between fecal gut microbiome, enteric pathogens, and energy regulating hormones among acutely malnourished rural Gambian children. eBioMedicine, 73, e103644. Article 103644. https://doi.org/10.1016/j.ebiom.2021.103644

@article{5f447c751dfa46b5b1e1bcb4d97f1f9d,

title = "Interactions between fecal gut microbiome, enteric pathogens, and energy regulating hormones among acutely malnourished rural Gambian children",

abstract = "BackgroundThe specific roles that gut microbiota, known pathogens, and host energy-regulating hormones play in the pathogenesis of non-edematous severe acute malnutrition (marasmus SAM) and moderate acute malnutrition (MAM) during outpatient nutritional rehabilitation are yet to be explored.MethodsWe applied an ensemble of sample-specific (intra- and inter-modality) association networks to gain deeper insights into the pathogenesis of acute malnutrition and its severity among children under 5 years of age in rural Gambia, where marasmus SAM is most prevalent.FindingsChildren with marasmus SAM have distinct microbiome characteristics and biologically-relevant multimodal biomarkers not observed among children with moderate acute malnutrition. Marasmus SAM was characterized by lower microbial richness and biomass, significant enrichments in Enterobacteriaceae, altered interactions between specific Enterobacteriaceae and key energy regulating hormones and their receptors.InterpretationOur findings suggest that marasmus SAM is characterized by the collapse of a complex system with nested interactions and key associations between the gut microbiome, enteric pathogens, and energy regulating hormones. Further exploration of these systems will help inform innovative preventive and therapeutic interventions.",

keywords = "Community detection, Enteric pathogens, Escherichia-Shigella, Feature selection, Gut microbiome, Malnutrition, Network analysis, West Africa",

author = "Helen Nabwera and Espinoza, \{Josh L.\} and Archibald Worwui and Modupeh Betts and Catherine Okoi and Sesay, \{Abdul K.\} and Rowan Bancroft and Agbla, \{Schadrac C.\} and Sheikh Jarju and Bradbury, \{Richard S.\} and Mariama Colley and Jallow, \{Amadou T.\} and Jie Liu and Houpt, \{Eric R.\} and Prentice, \{Andrew M.\} and Martin Antonio and Bernstein, \{Robin M.\} and Dupont, \{Christopher L.\} and Brenda Kwambana",

year = "2021",

month = nov,

day = "1",

doi = "10.1016/j.ebiom.2021.103644",

language = "English",

volume = "73",

pages = "e103644",

journal = "eBioMedicine",

issn = "2352-3964",

publisher = "Elsevier B.V.",

}

Nabwera, H, Espinoza, JL, Worwui, A, Betts, M, Okoi, C, Sesay, AK, Bancroft, R, Agbla, SC, Jarju, S, Bradbury, RS, Colley, M, Jallow, AT, Liu, J, Houpt, ER, Prentice, AM, Antonio, M, Bernstein, RM, Dupont, CL & Kwambana, B 2021, 'Interactions between fecal gut microbiome, enteric pathogens, and energy regulating hormones among acutely malnourished rural Gambian children', eBioMedicine, vol. 73, 103644, pp. e103644. https://doi.org/10.1016/j.ebiom.2021.103644

TY - JOUR

T1 - Interactions between fecal gut microbiome, enteric pathogens, and energy regulating hormones among acutely malnourished rural Gambian children

AU - Nabwera, Helen

AU - Espinoza, Josh L.

AU - Worwui, Archibald

AU - Betts, Modupeh

AU - Okoi, Catherine

AU - Sesay, Abdul K.

AU - Bancroft, Rowan

AU - Agbla, Schadrac C.

AU - Jarju, Sheikh

AU - Bradbury, Richard S.

AU - Colley, Mariama

AU - Jallow, Amadou T.

AU - Liu, Jie

AU - Houpt, Eric R.

AU - Prentice, Andrew M.

AU - Antonio, Martin

AU - Bernstein, Robin M.

AU - Dupont, Christopher L.

AU - Kwambana, Brenda

PY - 2021/11/1

Y1 - 2021/11/1

N2 - BackgroundThe specific roles that gut microbiota, known pathogens, and host energy-regulating hormones play in the pathogenesis of non-edematous severe acute malnutrition (marasmus SAM) and moderate acute malnutrition (MAM) during outpatient nutritional rehabilitation are yet to be explored.MethodsWe applied an ensemble of sample-specific (intra- and inter-modality) association networks to gain deeper insights into the pathogenesis of acute malnutrition and its severity among children under 5 years of age in rural Gambia, where marasmus SAM is most prevalent.FindingsChildren with marasmus SAM have distinct microbiome characteristics and biologically-relevant multimodal biomarkers not observed among children with moderate acute malnutrition. Marasmus SAM was characterized by lower microbial richness and biomass, significant enrichments in Enterobacteriaceae, altered interactions between specific Enterobacteriaceae and key energy regulating hormones and their receptors.InterpretationOur findings suggest that marasmus SAM is characterized by the collapse of a complex system with nested interactions and key associations between the gut microbiome, enteric pathogens, and energy regulating hormones. Further exploration of these systems will help inform innovative preventive and therapeutic interventions.

AB - BackgroundThe specific roles that gut microbiota, known pathogens, and host energy-regulating hormones play in the pathogenesis of non-edematous severe acute malnutrition (marasmus SAM) and moderate acute malnutrition (MAM) during outpatient nutritional rehabilitation are yet to be explored.MethodsWe applied an ensemble of sample-specific (intra- and inter-modality) association networks to gain deeper insights into the pathogenesis of acute malnutrition and its severity among children under 5 years of age in rural Gambia, where marasmus SAM is most prevalent.FindingsChildren with marasmus SAM have distinct microbiome characteristics and biologically-relevant multimodal biomarkers not observed among children with moderate acute malnutrition. Marasmus SAM was characterized by lower microbial richness and biomass, significant enrichments in Enterobacteriaceae, altered interactions between specific Enterobacteriaceae and key energy regulating hormones and their receptors.InterpretationOur findings suggest that marasmus SAM is characterized by the collapse of a complex system with nested interactions and key associations between the gut microbiome, enteric pathogens, and energy regulating hormones. Further exploration of these systems will help inform innovative preventive and therapeutic interventions.

KW - Community detection

KW - Enteric pathogens

KW - Escherichia-Shigella

KW - Feature selection

KW - Gut microbiome

KW - Malnutrition

KW - Network analysis

KW - West Africa

U2 - 10.1016/j.ebiom.2021.103644

DO - 10.1016/j.ebiom.2021.103644

M3 - Article

SN - 2352-3964

VL - 73

SP - e103644

JO - eBioMedicine

JF - eBioMedicine

M1 - 103644

ER -

Interactions between fecal gut microbiome, enteric pathogens, and energy regulating hormones among acutely malnourished rural Gambian children

Abstract

UN SDGs

Keywords

Access to Document

Fingerprint

Cite this