Insecticides for Mosquito Control: Improving and Validating Methods to Strengthen the Evidence Base

Efforts to eliminate vector-borne diseases, for example malaria which caused an estimated 619,000 deaths in 2021 [1] or arboviral diseases such as dengue and zika [2], rely heavily on the use of vector control tools. The toolbox available to combat insect vectors of disease is growing through improvements to existing approaches and new, emerging, technologies. New chemistries are being developed to target pyrethroid-resistant malaria vectors, for use in conventional tools such as insecticide-treated nets (ITNs) and indoor residual sprays (IRS), as well as through innovative means of deployment such as attractive targeted sugar baits (ATSB), passive emanators and eave tubes. Rear and release strategies to control Aedes vectors of arboviruses are under pilot evaluation, including versions of the sterile insect technique (SIT) and the use of Wolbachia symbionts for population control or replacement. These tools are also being piloted to urgently combat the expansion of Anopheles stephensi in Africa.

The decision to deploy new vector control tools or approaches on an operational level should be supported by robust entomological evidence to demonstrate efficacy, comprising data collected using appropriate and validated methods. A strong evidence base can also guide effective operational deployment decisions. The Insects Special Issue “Insecticides for Mosquito Control: Strengthening the Evidence Base” presents original research into developing and characterising new vector control products, as well as understanding and monitoring insecticide resistance. Review articles explore the impact of insecticide resistance and offer guidance on insecticide choice in the face of pyrethroid resistance. Consensus methodologies are presented, in the form of standard operating procedures (SOPs) designed to be adopted and used to generate reproducible data that can be compared and interpreted across and between studies. It is hoped that this Special Issue offers inspiration and guidance on how consistent data can be generated to inform more effective development, evaluation and use of new and existing vector control tools.