Insecticide-treated nets provide protection against malaria to children in an area of insecticide resistance in Southern Benin

John Bradley; Aurore Ogouyèmi-Hounto; Sylvie Cornélie; Jacob Fassinou; Yolande Sissinto Savi De Tove; Adicath Adéola Adéothy; Filémon T. Tokponnon; Patrick Makoutode; Alioun Adechoubou; Thibaut Legba; Telesphore Houansou; Dorothée Kinde-Gazard; Martin C. Akogbeto; Achille Massougbodji; Tessa Bellamy Knox; Martin Donnelly; Immo Kleinschmidt

doi:10.1186/s12936-017-1873-1

Insecticide-treated nets provide protection against malaria to children in an area of insecticide resistance in Southern Benin

John Bradley
, Aurore Ogouyèmi-Hounto
, Sylvie Cornélie
, Jacob Fassinou
, Yolande Sissinto Savi De Tove
, Adicath Adéola Adéothy
, Filémon T. Tokponnon
, Patrick Makoutode
, Alioun Adechoubou
, Thibaut Legba
, Telesphore Houansou
, Dorothée Kinde-Gazard
, Martin C. Akogbeto
, Achille Massougbodji
, Tessa Bellamy Knox
, Martin Donnelly
, Immo Kleinschmidt

Vector Biology

London School of Hygiene and Tropical Medicine
Faculté des sciences de la santé de Cotonou
Centre de recherche entomologique de Cotonou
Programme National de Lutte contre le paludisme Cotonou
World Health Organization

Research output: Contribution to journal › Article › peer-review

29 Citations (Scopus)

Abstract

Background

Malaria control is heavily reliant on insecticides, especially pyrethroids. Resistance of mosquitoes to insecticides may threaten the effectiveness of insecticide-based vector control and lead to a resurgence of malaria in Africa.

Methods

In 21 villages in Southern Benin with high levels of insecticide resistance, the resistance status of local vectors was measured at the same time as the prevalence of malaria infection in resident children.

Results

Children who used LLINs had lower levels of malaria infection [odds ratio = 0.76 (95% CI 0.59, 0.98, p = 0.033)]. There was no evidence that the effectiveness of nets was different in high and low resistance locations (p = 0.513). There was no association between village level resistance and village level malaria prevalence (p = 0.999).

Conclusions

LLINs continue to offer individual protection against malaria infection in an area of high resistance. Insecticide resistance is not a reason to stop efforts to increase coverage of LLINs in Africa.

Original language	English
Article number	225
Pages (from-to)	225
Journal	Malaria Journal
Volume	16
Issue number	1
DOIs	https://doi.org/10.1186/s12936-017-1873-1
Publication status	Published - 26 May 2017

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Insecticide
Malaria
Nets
Pyrethroid
Resistance

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10.1186/s12936-017-1873-1Licence: CC BY

Malar J Insecticide-treated nets 2017 16 225Final published version, 877 KBLicence: CC BY

Cite this

Bradley, J., Ogouyèmi-Hounto, A., Cornélie, S., Fassinou, J., De Tove, Y. S. S., Adéothy, A. A., Tokponnon, F. T., Makoutode, P., Adechoubou, A., Legba, T., Houansou, T., Kinde-Gazard, D., Akogbeto, M. C., Massougbodji, A., Knox, T. B., Donnelly, M., & Kleinschmidt, I. (2017). Insecticide-treated nets provide protection against malaria to children in an area of insecticide resistance in Southern Benin. Malaria Journal, 16(1), 225. Article 225. https://doi.org/10.1186/s12936-017-1873-1

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title = "Insecticide-treated nets provide protection against malaria to children in an area of insecticide resistance in Southern Benin",

abstract = "BackgroundMalaria control is heavily reliant on insecticides, especially pyrethroids. Resistance of mosquitoes to insecticides may threaten the effectiveness of insecticide-based vector control and lead to a resurgence of malaria in Africa.MethodsIn 21 villages in Southern Benin with high levels of insecticide resistance, the resistance status of local vectors was measured at the same time as the prevalence of malaria infection in resident children.ResultsChildren who used LLINs had lower levels of malaria infection [odds ratio = 0.76 (95\% CI 0.59, 0.98, p = 0.033)]. There was no evidence that the effectiveness of nets was different in high and low resistance locations (p = 0.513). There was no association between village level resistance and village level malaria prevalence (p = 0.999).ConclusionsLLINs continue to offer individual protection against malaria infection in an area of high resistance. Insecticide resistance is not a reason to stop efforts to increase coverage of LLINs in Africa.",

keywords = "Insecticide, Malaria, Nets, Pyrethroid, Resistance",

author = "John Bradley and Aurore Ogouy{\`e}mi-Hounto and Sylvie Corn{\'e}lie and Jacob Fassinou and \{De Tove\}, \{Yolande Sissinto Savi\} and Ad{\'e}othy, \{Adicath Ad{\'e}ola\} and Tokponnon, \{Fil{\'e}mon T.\} and Patrick Makoutode and Alioun Adechoubou and Thibaut Legba and Telesphore Houansou and Doroth{\'e}e Kinde-Gazard and Akogbeto, \{Martin C.\} and Achille Massougbodji and Knox, \{Tessa Bellamy\} and Martin Donnelly and Immo Kleinschmidt",

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month = may,

day = "26",

doi = "10.1186/s12936-017-1873-1",

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Bradley, J, Ogouyèmi-Hounto, A, Cornélie, S, Fassinou, J, De Tove, YSS, Adéothy, AA, Tokponnon, FT, Makoutode, P, Adechoubou, A, Legba, T, Houansou, T, Kinde-Gazard, D, Akogbeto, MC, Massougbodji, A, Knox, TB, Donnelly, M & Kleinschmidt, I 2017, 'Insecticide-treated nets provide protection against malaria to children in an area of insecticide resistance in Southern Benin', Malaria Journal, vol. 16, no. 1, 225, pp. 225. https://doi.org/10.1186/s12936-017-1873-1

TY - JOUR

T1 - Insecticide-treated nets provide protection against malaria to children in an area of insecticide resistance in Southern Benin

AU - Bradley, John

AU - Ogouyèmi-Hounto, Aurore

AU - Cornélie, Sylvie

AU - Fassinou, Jacob

AU - De Tove, Yolande Sissinto Savi

AU - Adéothy, Adicath Adéola

AU - Tokponnon, Filémon T.

AU - Makoutode, Patrick

AU - Adechoubou, Alioun

AU - Legba, Thibaut

AU - Houansou, Telesphore

AU - Kinde-Gazard, Dorothée

AU - Akogbeto, Martin C.

AU - Massougbodji, Achille

AU - Knox, Tessa Bellamy

AU - Donnelly, Martin

AU - Kleinschmidt, Immo

PY - 2017/5/26

Y1 - 2017/5/26

N2 - BackgroundMalaria control is heavily reliant on insecticides, especially pyrethroids. Resistance of mosquitoes to insecticides may threaten the effectiveness of insecticide-based vector control and lead to a resurgence of malaria in Africa.MethodsIn 21 villages in Southern Benin with high levels of insecticide resistance, the resistance status of local vectors was measured at the same time as the prevalence of malaria infection in resident children.ResultsChildren who used LLINs had lower levels of malaria infection [odds ratio = 0.76 (95% CI 0.59, 0.98, p = 0.033)]. There was no evidence that the effectiveness of nets was different in high and low resistance locations (p = 0.513). There was no association between village level resistance and village level malaria prevalence (p = 0.999).ConclusionsLLINs continue to offer individual protection against malaria infection in an area of high resistance. Insecticide resistance is not a reason to stop efforts to increase coverage of LLINs in Africa.

AB - BackgroundMalaria control is heavily reliant on insecticides, especially pyrethroids. Resistance of mosquitoes to insecticides may threaten the effectiveness of insecticide-based vector control and lead to a resurgence of malaria in Africa.MethodsIn 21 villages in Southern Benin with high levels of insecticide resistance, the resistance status of local vectors was measured at the same time as the prevalence of malaria infection in resident children.ResultsChildren who used LLINs had lower levels of malaria infection [odds ratio = 0.76 (95% CI 0.59, 0.98, p = 0.033)]. There was no evidence that the effectiveness of nets was different in high and low resistance locations (p = 0.513). There was no association between village level resistance and village level malaria prevalence (p = 0.999).ConclusionsLLINs continue to offer individual protection against malaria infection in an area of high resistance. Insecticide resistance is not a reason to stop efforts to increase coverage of LLINs in Africa.

KW - Insecticide

KW - Malaria

KW - Nets

KW - Pyrethroid

KW - Resistance

U2 - 10.1186/s12936-017-1873-1

DO - 10.1186/s12936-017-1873-1

M3 - Article

SN - 1475-2875

VL - 16

SP - 225

JO - Malaria Journal

JF - Malaria Journal

IS - 1

M1 - 225

ER -

Insecticide-treated nets provide protection against malaria to children in an area of insecticide resistance in Southern Benin

Abstract

UN SDGs

Keywords

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