Insecticide-Treated Net and Protection against Insecticide-Resistant Malaria Vectors in Western Kenya

Eric Ochomo; Mercy Chahilu; Jackie Cook; Teresa Kinyari; Nabie M. Bayoh; Philippa West; Luna Kamau; Aggrey Osangale; Maurice Ombok; Kiambo Njagi; Evan Mathenge; Lawrence Muthami; Krishanthi Subramaniam; Tessa Knox; Abraham Mnavaza; Martin Donnelly; Immo Kleinschmidt; Charles Mbogo

doi:10.3201/eid2305.161315

Insecticide-Treated Net and Protection against Insecticide-Resistant Malaria Vectors in Western Kenya

Eric Ochomo
, Mercy Chahilu
, Jackie Cook
, Teresa Kinyari
, Nabie M. Bayoh
, Philippa West
, Luna Kamau
, Aggrey Osangale
, Maurice Ombok
, Kiambo Njagi
, Evan Mathenge
, Lawrence Muthami
, Krishanthi Subramaniam
, Tessa Knox
, Abraham Mnavaza
, Martin Donnelly
, Immo Kleinschmidt
, Charles Mbogo

Vector Biology

Kenya Medical Research Institute
London School of Hygiene and Tropical Medicine
University of Nairobi
Centers for Disease Control and Prevention
Ministry of Health, Kenya
Liverpool School of Tropical Medicine
World Health Organization
University of the Witwatersrand
Wellcome Trust Research Laboratories Nairobi

Research output: Contribution to journal › Article › peer-review

44 Citations (Scopus)

Abstract

Insecticide resistance might reduce the efficacy of malaria vector control. In 2013 and 2014, malaria vectors from 50 villages, of varying pyrethroid resistance, in western Kenya were assayed for resistance to deltamethrin. Long-lasting insecticide-treated nets (LLIN) were distributed to households at universal coverage. Children were recruited into 2 cohorts, cleared of malaria-causing parasites, and tested every 2 weeks for reinfection. Infection incidence rates for the 2 cohorts were 2.2 (95% CI 1.9–2.5) infections/person-year and 2.8 (95% CI 2.5–3.0) infections/person-year. LLIN users had lower infection rates than non-LLIN users in both low-resistance (rate ratio 0.61, 95% CI 0.42–0.88) and high-resistance (rate ratio 0.55, 95% CI 0.35–0.87) villages (p = 0.63). The association between insecticide resistance and infection incidence was not significant (p = 0.99). Although the incidence of infection was high among net users, LLINs provided significant protection (p = 0.01) against infection with malaria parasite regardless of vector insecticide resistance

Original language	English
Pages (from-to)	758-764
Number of pages	7
Journal	Emerging Infectious Diseases
Volume	23
Issue number	5
DOIs	https://doi.org/10.3201/eid2305.161315
Publication status	Published - 3 May 2017

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

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Ochomo et al 2017 EIDFinal published version, 928 KBLicence: CC BY

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Ochomo, E., Chahilu, M., Cook, J., Kinyari, T., Bayoh, N. M., West, P., Kamau, L., Osangale, A., Ombok, M., Njagi, K., Mathenge, E., Muthami, L., Subramaniam, K., Knox, T., Mnavaza, A., Donnelly, M., Kleinschmidt, I., & Mbogo, C. (2017). Insecticide-Treated Net and Protection against Insecticide-Resistant Malaria Vectors in Western Kenya. Emerging Infectious Diseases, 23(5), 758-764. https://doi.org/10.3201/eid2305.161315

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title = "Insecticide-Treated Net and Protection against Insecticide-Resistant Malaria Vectors in Western Kenya",

abstract = "Insecticide resistance might reduce the efficacy of malaria vector control. In 2013 and 2014, malaria vectors from 50 villages, of varying pyrethroid resistance, in western Kenya were assayed for resistance to deltamethrin. Long-lasting insecticide-treated nets (LLIN) were distributed to households at universal coverage. Children were recruited into 2 cohorts, cleared of malaria-causing parasites, and tested every 2 weeks for reinfection. Infection incidence rates for the 2 cohorts were 2.2 (95\% CI 1.9–2.5) infections/person-year and 2.8 (95\% CI 2.5–3.0) infections/person-year. LLIN users had lower infection rates than non-LLIN users in both low-resistance (rate ratio 0.61, 95\% CI 0.42–0.88) and high-resistance (rate ratio 0.55, 95\% CI 0.35–0.87) villages (p = 0.63). The association between insecticide resistance and infection incidence was not significant (p = 0.99). Although the incidence of infection was high among net users, LLINs provided significant protection (p = 0.01) against infection with malaria parasite regardless of vector insecticide resistance",

author = "Eric Ochomo and Mercy Chahilu and Jackie Cook and Teresa Kinyari and Bayoh, \{Nabie M.\} and Philippa West and Luna Kamau and Aggrey Osangale and Maurice Ombok and Kiambo Njagi and Evan Mathenge and Lawrence Muthami and Krishanthi Subramaniam and Tessa Knox and Abraham Mnavaza and Martin Donnelly and Immo Kleinschmidt and Charles Mbogo",

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doi = "10.3201/eid2305.161315",

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Ochomo, E, Chahilu, M, Cook, J, Kinyari, T, Bayoh, NM, West, P, Kamau, L, Osangale, A, Ombok, M, Njagi, K, Mathenge, E, Muthami, L, Subramaniam, K, Knox, T, Mnavaza, A, Donnelly, M, Kleinschmidt, I & Mbogo, C 2017, 'Insecticide-Treated Net and Protection against Insecticide-Resistant Malaria Vectors in Western Kenya', Emerging Infectious Diseases, vol. 23, no. 5, pp. 758-764. https://doi.org/10.3201/eid2305.161315

TY - JOUR

T1 - Insecticide-Treated Net and Protection against Insecticide-Resistant Malaria Vectors in Western Kenya

AU - Ochomo, Eric

AU - Chahilu, Mercy

AU - Cook, Jackie

AU - Kinyari, Teresa

AU - Bayoh, Nabie M.

AU - West, Philippa

AU - Kamau, Luna

AU - Osangale, Aggrey

AU - Ombok, Maurice

AU - Njagi, Kiambo

AU - Mathenge, Evan

AU - Muthami, Lawrence

AU - Subramaniam, Krishanthi

AU - Knox, Tessa

AU - Mnavaza, Abraham

AU - Donnelly, Martin

AU - Kleinschmidt, Immo

AU - Mbogo, Charles

PY - 2017/5/3

Y1 - 2017/5/3

N2 - Insecticide resistance might reduce the efficacy of malaria vector control. In 2013 and 2014, malaria vectors from 50 villages, of varying pyrethroid resistance, in western Kenya were assayed for resistance to deltamethrin. Long-lasting insecticide-treated nets (LLIN) were distributed to households at universal coverage. Children were recruited into 2 cohorts, cleared of malaria-causing parasites, and tested every 2 weeks for reinfection. Infection incidence rates for the 2 cohorts were 2.2 (95% CI 1.9–2.5) infections/person-year and 2.8 (95% CI 2.5–3.0) infections/person-year. LLIN users had lower infection rates than non-LLIN users in both low-resistance (rate ratio 0.61, 95% CI 0.42–0.88) and high-resistance (rate ratio 0.55, 95% CI 0.35–0.87) villages (p = 0.63). The association between insecticide resistance and infection incidence was not significant (p = 0.99). Although the incidence of infection was high among net users, LLINs provided significant protection (p = 0.01) against infection with malaria parasite regardless of vector insecticide resistance

AB - Insecticide resistance might reduce the efficacy of malaria vector control. In 2013 and 2014, malaria vectors from 50 villages, of varying pyrethroid resistance, in western Kenya were assayed for resistance to deltamethrin. Long-lasting insecticide-treated nets (LLIN) were distributed to households at universal coverage. Children were recruited into 2 cohorts, cleared of malaria-causing parasites, and tested every 2 weeks for reinfection. Infection incidence rates for the 2 cohorts were 2.2 (95% CI 1.9–2.5) infections/person-year and 2.8 (95% CI 2.5–3.0) infections/person-year. LLIN users had lower infection rates than non-LLIN users in both low-resistance (rate ratio 0.61, 95% CI 0.42–0.88) and high-resistance (rate ratio 0.55, 95% CI 0.35–0.87) villages (p = 0.63). The association between insecticide resistance and infection incidence was not significant (p = 0.99). Although the incidence of infection was high among net users, LLINs provided significant protection (p = 0.01) against infection with malaria parasite regardless of vector insecticide resistance

U2 - 10.3201/eid2305.161315

DO - 10.3201/eid2305.161315

M3 - Article

SN - 1080-6040

VL - 23

SP - 758

EP - 764

JO - Emerging Infectious Diseases

JF - Emerging Infectious Diseases

IS - 5

ER -

Insecticide-Treated Net and Protection against Insecticide-Resistant Malaria Vectors in Western Kenya

Abstract

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