TY - JOUR
T1 - Insecticide-Treated Net and Protection against Insecticide-Resistant Malaria Vectors in Western Kenya
AU - Ochomo, Eric
AU - Chahilu, Mercy
AU - Cook, Jackie
AU - Kinyari, Teresa
AU - Bayoh, Nabie M.
AU - West, Philippa
AU - Kamau, Luna
AU - Osangale, Aggrey
AU - Ombok, Maurice
AU - Njagi, Kiambo
AU - Mathenge, Evan
AU - Muthami, Lawrence
AU - Subramaniam, Krishanthi
AU - Knox, Tessa
AU - Mnavaza, Abraham
AU - Donnelly, Martin
AU - Kleinschmidt, Immo
AU - Mbogo, Charles
PY - 2017/5/3
Y1 - 2017/5/3
N2 - Insecticide resistance might reduce the efficacy of malaria vector control. In 2013 and 2014, malaria vectors from 50 villages, of varying pyrethroid resistance, in western Kenya were assayed for resistance to deltamethrin. Long-lasting insecticide-treated nets (LLIN) were distributed to households at universal coverage. Children were recruited into 2 cohorts, cleared of malaria-causing parasites, and tested every 2 weeks for reinfection. Infection incidence rates for the 2 cohorts were 2.2 (95% CI 1.9–2.5) infections/person-year and 2.8 (95% CI 2.5–3.0) infections/person-year. LLIN users had lower infection rates than non-LLIN users in both low-resistance (rate ratio 0.61, 95% CI 0.42–0.88) and high-resistance (rate ratio 0.55, 95% CI 0.35–0.87) villages (p = 0.63). The association between insecticide resistance and infection incidence was not significant (p = 0.99). Although the incidence of infection was high among net users, LLINs provided significant protection (p = 0.01) against infection with malaria parasite regardless of vector insecticide resistance
AB - Insecticide resistance might reduce the efficacy of malaria vector control. In 2013 and 2014, malaria vectors from 50 villages, of varying pyrethroid resistance, in western Kenya were assayed for resistance to deltamethrin. Long-lasting insecticide-treated nets (LLIN) were distributed to households at universal coverage. Children were recruited into 2 cohorts, cleared of malaria-causing parasites, and tested every 2 weeks for reinfection. Infection incidence rates for the 2 cohorts were 2.2 (95% CI 1.9–2.5) infections/person-year and 2.8 (95% CI 2.5–3.0) infections/person-year. LLIN users had lower infection rates than non-LLIN users in both low-resistance (rate ratio 0.61, 95% CI 0.42–0.88) and high-resistance (rate ratio 0.55, 95% CI 0.35–0.87) villages (p = 0.63). The association between insecticide resistance and infection incidence was not significant (p = 0.99). Although the incidence of infection was high among net users, LLINs provided significant protection (p = 0.01) against infection with malaria parasite regardless of vector insecticide resistance
U2 - 10.3201/eid2305.161315
DO - 10.3201/eid2305.161315
M3 - Article
SN - 1080-6040
VL - 23
SP - 758
EP - 764
JO - Emerging Infectious Diseases
JF - Emerging Infectious Diseases
IS - 5
ER -
