Insect cuticle: a critical determinant of insecticide resistance.

Vasileia Balabanidou; Linta Grigoraki; John Vontas

doi:10.1016/j.cois.2018.03.001

Insect cuticle: a critical determinant of insecticide resistance.

Vasileia Balabanidou, Linta Grigoraki, John Vontas

Vector Biology

Research output: Contribution to journal › Review article › peer-review

375 Citations (Scopus)

Abstract

Intense use of insecticides has resulted in the selection of extreme levels of resistance in insect populations. Therefore understanding the molecular basis of insecticide resistance mechanisms becomes critical. Penetration resistance refers to modifications in the cuticle that will eventually slow down the penetration of insecticide molecules within insects' body. So far, two mechanisms of penetration resistance have been described, the cuticle thickening and the altering of cuticle composition. Cuticular modifications are attributed to the over-expression of diversified genes or proteins, which belong to structural components (cuticular proteins mainly), enzymes that catalyze enzymatic reactions (CYP4G16 and laccase 2) or ABC transporters that promote cuticular translocation. In the present review we summarize recent studies and discuss future perspectives.

Original language	English
Pages (from-to)	68-74
Number of pages	7
Journal	Current Opinion in Insect Science
Volume	27
Early online date	6 Mar 2018
DOIs	https://doi.org/10.1016/j.cois.2018.03.001
Publication status	Published - 27 Jun 2018

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10.1016/j.cois.2018.03.001

Insect cuticle insecticide resistance and figuresAccepted author manuscript, 294 KBLicence: CC BY-NC-ND

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title = "Insect cuticle: a critical determinant of insecticide resistance.",

abstract = "Intense use of insecticides has resulted in the selection of extreme levels of resistance in insect populations. Therefore understanding the molecular basis of insecticide resistance mechanisms becomes critical. Penetration resistance refers to modifications in the cuticle that will eventually slow down the penetration of insecticide molecules within insects' body. So far, two mechanisms of penetration resistance have been described, the cuticle thickening and the altering of cuticle composition. Cuticular modifications are attributed to the over-expression of diversified genes or proteins, which belong to structural components (cuticular proteins mainly), enzymes that catalyze enzymatic reactions (CYP4G16 and laccase 2) or ABC transporters that promote cuticular translocation. In the present review we summarize recent studies and discuss future perspectives.",

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AU - Balabanidou, Vasileia

AU - Grigoraki, Linta

AU - Vontas, John

PY - 2018/6/27

Y1 - 2018/6/27

N2 - Intense use of insecticides has resulted in the selection of extreme levels of resistance in insect populations. Therefore understanding the molecular basis of insecticide resistance mechanisms becomes critical. Penetration resistance refers to modifications in the cuticle that will eventually slow down the penetration of insecticide molecules within insects' body. So far, two mechanisms of penetration resistance have been described, the cuticle thickening and the altering of cuticle composition. Cuticular modifications are attributed to the over-expression of diversified genes or proteins, which belong to structural components (cuticular proteins mainly), enzymes that catalyze enzymatic reactions (CYP4G16 and laccase 2) or ABC transporters that promote cuticular translocation. In the present review we summarize recent studies and discuss future perspectives.

AB - Intense use of insecticides has resulted in the selection of extreme levels of resistance in insect populations. Therefore understanding the molecular basis of insecticide resistance mechanisms becomes critical. Penetration resistance refers to modifications in the cuticle that will eventually slow down the penetration of insecticide molecules within insects' body. So far, two mechanisms of penetration resistance have been described, the cuticle thickening and the altering of cuticle composition. Cuticular modifications are attributed to the over-expression of diversified genes or proteins, which belong to structural components (cuticular proteins mainly), enzymes that catalyze enzymatic reactions (CYP4G16 and laccase 2) or ABC transporters that promote cuticular translocation. In the present review we summarize recent studies and discuss future perspectives.

U2 - 10.1016/j.cois.2018.03.001

DO - 10.1016/j.cois.2018.03.001

M3 - Review article

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VL - 27

SP - 68

EP - 74

JO - Current Opinion in Insect Science

JF - Current Opinion in Insect Science

ER -

Insect cuticle: a critical determinant of insecticide resistance.

Abstract

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