Innovative vaccine approaches—a Keystone Symposia report

Jennifer Cable; Rino Rappuoli; Elizabeth J. Klemm; Gagandeep Kang; Ankur Mutreja; Gavin J. Wright; Mariagrazia Pizza; Sowmya Ajay Castro; Joseph P. Hoffmann; Galit Alter; Andrea Carfi; Andrew J. Pollard; Florian Krammer; Ravindra K. Gupta; Caroline E. Wagner; Viviane Machado; Kayvon Modjarrad; Lawrence Corey; Peter B. Gilbert; Gordon Dougan; Nicole Lurie; Pamela J. Bjorkman; Christopher Chiu; Elisa Nemes; Stephen Gordon; Andrew C. Steer; Thomas Rudel; Catherine A. Blish; John Tyler Sandberg; Kiva Brennan; Keith P. Klugman; Lynda M. Stuart; Shabir A. Madhi; Christopher L. Karp

doi:10.1111/nyas.14739

Innovative vaccine approaches—a Keystone Symposia report

Jennifer Cable
, Rino Rappuoli
, Elizabeth J. Klemm
, Gagandeep Kang
, Ankur Mutreja
, Gavin J. Wright
, Mariagrazia Pizza
, Sowmya Ajay Castro
, Joseph P. Hoffmann
, Galit Alter
, Andrea Carfi
, Andrew J. Pollard
, Florian Krammer
, Ravindra K. Gupta
, Caroline E. Wagner
, Viviane Machado
, Kayvon Modjarrad
, Lawrence Corey
, Peter B. Gilbert
, Gordon Dougan

Nicole Lurie, Pamela J. Bjorkman, Christopher Chiu, Elisa Nemes, Stephen Gordon, Andrew C. Steer, Thomas Rudel, Catherine A. Blish, John Tyler Sandberg, Kiva Brennan, Keith P. Klugman, Lynda M. Stuart, Shabir A. Madhi, Christopher L. Karp

PhD Science Writer
GlaxoSmithKline
Wellcome Trust
Christian Medical College
University of Cambridge
Wellcome Sanger Institute
University of York
University of Dundee
Tulane University
Harvard University
Moderna Therapeutics
NIHR Oxford Biomedical Research Centre
Icahn School of Medicine at Mount Sinai
Africa Health Research Institute
McGill University
Fundação Oswaldo Cruz
Walter Reed Army Institute of Research
University of Washington
Fred Hutchinson Cancer Research Center
Coalition for Epidemic Preparedness Innovations
California Institute of Technology
Imperial College London
University of Cape Town
Malawi-Liverpool-Wellcome Trust Clinical Research Programme
Murdoch Children's Research Institute
University of Melbourne
Royal Children's Hospital
University of Würzburg
Stanford University
Chan Zuckerberg Biohub
Karolinska Institutet
Children’s Health Ireland
Emory University
Virginia Mason Medical Center
Gates Foundation
University of the Witwatersrand

Research output: Contribution to journal › Article › peer-review

4 Citations (Scopus)

Abstract

The rapid development of COVID-19 vaccines was the result of decades of research to establish flexible vaccine platforms and understand pathogens with pandemic potential, as well as several novel changes to the vaccine discovery and development processes that partnered industry and governments. And while vaccines offer the potential to drastically improve global health, low-and-middle-income countries around the world often experience reduced access to vaccines and reduced vaccine efficacy. Addressing these issues will require novel vaccine approaches and platforms, deeper insight how vaccines mediate protection, and innovative trial designs and models. On June 28–30, 2021, experts in vaccine research, development, manufacturing, and deployment met virtually for the Keystone eSymposium “Innovative Vaccine Approaches” to discuss advances in vaccine research and development.

Original language	English
Pages (from-to)	59-86
Number of pages	28
Journal	Annals of the New York Academy of Sciences
Volume	1511
Issue number	1
DOIs	https://doi.org/10.1111/nyas.14739
Publication status	Published - 1 May 2022
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

correlates of protection
COVID-19
human challenge studies
influenza
pneumococcal disease
streptococcus
vaccine equity
vaccines

Access to Document

10.1111/nyas.14739

Cite this

Cable, J., Rappuoli, R., Klemm, E. J., Kang, G., Mutreja, A., Wright, G. J., Pizza, M., Castro, S. A., Hoffmann, J. P., Alter, G., Carfi, A., Pollard, A. J., Krammer, F., Gupta, R. K., Wagner, C. E., Machado, V., Modjarrad, K., Corey, L., B. Gilbert, P., ... Karp, C. L. (2022). Innovative vaccine approaches—a Keystone Symposia report. Annals of the New York Academy of Sciences, 1511(1), 59-86. https://doi.org/10.1111/nyas.14739

@article{b251f10d1aba441e922f27a9b87dec21,

title = "Innovative vaccine approaches—a Keystone Symposia report",

abstract = "The rapid development of COVID-19 vaccines was the result of decades of research to establish flexible vaccine platforms and understand pathogens with pandemic potential, as well as several novel changes to the vaccine discovery and development processes that partnered industry and governments. And while vaccines offer the potential to drastically improve global health, low-and-middle-income countries around the world often experience reduced access to vaccines and reduced vaccine efficacy. Addressing these issues will require novel vaccine approaches and platforms, deeper insight how vaccines mediate protection, and innovative trial designs and models. On June 28–30, 2021, experts in vaccine research, development, manufacturing, and deployment met virtually for the Keystone eSymposium “Innovative Vaccine Approaches” to discuss advances in vaccine research and development.",

keywords = "correlates of protection, COVID-19, human challenge studies, influenza, pneumococcal disease, streptococcus, vaccine equity, vaccines",

author = "Jennifer Cable and Rino Rappuoli and Klemm, \{Elizabeth J.\} and Gagandeep Kang and Ankur Mutreja and Wright, \{Gavin J.\} and Mariagrazia Pizza and Castro, \{Sowmya Ajay\} and Hoffmann, \{Joseph P.\} and Galit Alter and Andrea Carfi and Pollard, \{Andrew J.\} and Florian Krammer and Gupta, \{Ravindra K.\} and Wagner, \{Caroline E.\} and Viviane Machado and Kayvon Modjarrad and Lawrence Corey and \{B. Gilbert\}, Peter and Gordon Dougan and Nicole Lurie and Bjorkman, \{Pamela J.\} and Christopher Chiu and Elisa Nemes and Stephen Gordon and Steer, \{Andrew C.\} and Thomas Rudel and Blish, \{Catherine A.\} and Sandberg, \{John Tyler\} and Kiva Brennan and Klugman, \{Keith P.\} and Stuart, \{Lynda M.\} and Madhi, \{Shabir A.\} and Karp, \{Christopher L.\}",

year = "2022",

month = may,

day = "1",

doi = "10.1111/nyas.14739",

language = "English",

volume = "1511",

pages = "59--86",

journal = "Annals of the New York Academy of Sciences",

issn = "0077-8923",

publisher = "John Wiley and Sons Inc",

number = "1",

}

Cable, J, Rappuoli, R, Klemm, EJ, Kang, G, Mutreja, A, Wright, GJ, Pizza, M, Castro, SA, Hoffmann, JP, Alter, G, Carfi, A, Pollard, AJ, Krammer, F, Gupta, RK, Wagner, CE, Machado, V, Modjarrad, K, Corey, L, B. Gilbert, P, Dougan, G, Lurie, N, Bjorkman, PJ, Chiu, C, Nemes, E, Gordon, S, Steer, AC, Rudel, T, Blish, CA, Sandberg, JT, Brennan, K, Klugman, KP, Stuart, LM, Madhi, SA & Karp, CL 2022, 'Innovative vaccine approaches—a Keystone Symposia report', Annals of the New York Academy of Sciences, vol. 1511, no. 1, pp. 59-86. https://doi.org/10.1111/nyas.14739

TY - JOUR

T1 - Innovative vaccine approaches—a Keystone Symposia report

AU - Cable, Jennifer

AU - Rappuoli, Rino

AU - Klemm, Elizabeth J.

AU - Kang, Gagandeep

AU - Mutreja, Ankur

AU - Wright, Gavin J.

AU - Pizza, Mariagrazia

AU - Castro, Sowmya Ajay

AU - Hoffmann, Joseph P.

AU - Alter, Galit

AU - Carfi, Andrea

AU - Pollard, Andrew J.

AU - Krammer, Florian

AU - Gupta, Ravindra K.

AU - Wagner, Caroline E.

AU - Machado, Viviane

AU - Modjarrad, Kayvon

AU - Corey, Lawrence

AU - B. Gilbert, Peter

AU - Dougan, Gordon

AU - Lurie, Nicole

AU - Bjorkman, Pamela J.

AU - Chiu, Christopher

AU - Nemes, Elisa

AU - Gordon, Stephen

AU - Steer, Andrew C.

AU - Rudel, Thomas

AU - Blish, Catherine A.

AU - Sandberg, John Tyler

AU - Brennan, Kiva

AU - Klugman, Keith P.

AU - Stuart, Lynda M.

AU - Madhi, Shabir A.

AU - Karp, Christopher L.

PY - 2022/5/1

Y1 - 2022/5/1

N2 - The rapid development of COVID-19 vaccines was the result of decades of research to establish flexible vaccine platforms and understand pathogens with pandemic potential, as well as several novel changes to the vaccine discovery and development processes that partnered industry and governments. And while vaccines offer the potential to drastically improve global health, low-and-middle-income countries around the world often experience reduced access to vaccines and reduced vaccine efficacy. Addressing these issues will require novel vaccine approaches and platforms, deeper insight how vaccines mediate protection, and innovative trial designs and models. On June 28–30, 2021, experts in vaccine research, development, manufacturing, and deployment met virtually for the Keystone eSymposium “Innovative Vaccine Approaches” to discuss advances in vaccine research and development.

AB - The rapid development of COVID-19 vaccines was the result of decades of research to establish flexible vaccine platforms and understand pathogens with pandemic potential, as well as several novel changes to the vaccine discovery and development processes that partnered industry and governments. And while vaccines offer the potential to drastically improve global health, low-and-middle-income countries around the world often experience reduced access to vaccines and reduced vaccine efficacy. Addressing these issues will require novel vaccine approaches and platforms, deeper insight how vaccines mediate protection, and innovative trial designs and models. On June 28–30, 2021, experts in vaccine research, development, manufacturing, and deployment met virtually for the Keystone eSymposium “Innovative Vaccine Approaches” to discuss advances in vaccine research and development.

KW - correlates of protection

KW - COVID-19

KW - human challenge studies

KW - influenza

KW - pneumococcal disease

KW - streptococcus

KW - vaccine equity

KW - vaccines

U2 - 10.1111/nyas.14739

DO - 10.1111/nyas.14739

M3 - Article

SN - 0077-8923

VL - 1511

SP - 59

EP - 86

JO - Annals of the New York Academy of Sciences

JF - Annals of the New York Academy of Sciences

IS - 1

ER -

Innovative vaccine approaches—a Keystone Symposia report

Abstract

UN SDGs

Keywords

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