TY - JOUR
T1 - Inflammation and Change in Body Weight with Antiretroviral Therapy Initiation in a Multinational Cohort of HIV-infected Adults.
AU - Mave, Vidya
AU - Erlandson, Kristine M
AU - Gupte, Nikhil
AU - Balgopal, Ashwin
AU - Asmuth, David M
AU - Campbell, Thomas B
AU - Smeaton, Laura
AU - Kumarasamy, Nagalingeswaran
AU - Hakim, James
AU - Santos, Breno
AU - Riviere, Cynthia
AU - Hosseinipour, Mina C
AU - Sugandhavesa, Patcharaphan
AU - Infante, Rosa
AU - Pillay, Sandy
AU - Cardoso, Sandra W
AU - Tripathy, Srikanth
AU - Mwelase, Noluthando
AU - Berendes, Sima
AU - Andrade, Bruno B
AU - Thomas, David L
AU - Bollinger, Robert C
AU - Gupta, Amita
PY - 2016/3/8
Y1 - 2016/3/8
N2 - BACKGROUNDBoth wasting and obesity are associated with inflammation, but the extent to which body weight changes influence inflammation in HIV is unknown.METHODSAmong a random virologically suppressed participants of the PEARLS trial, inflammatory markers were measured at weeks 0, 24, and 48 post-antiretroviral therapy (ART). Associations between baseline and change in body mass index (BMI) and inflammation changes were assessed using random effects models.RESULTSOf 246 participants, 27% were overweight/obese (BMI≥25 kg/m(2)) and 8% were underweight (BMI<18.5 kg/m(2)) at baseline. After 48 weeks, 37% were overweight/obese and 3% were underweight. While many inflammatory markers decreased 48 weeks after ART in the overall group, the decrease in CRP was smaller in overweight/obese participants (p=0.01) and the decreases in both CRP (p=0.01) and IL-18 (p=0.02) were smaller in underweight participants. Each 1 unit gain in BMI among overweight/obese participants was associated with a 0.02 log10 increase in sCD14 (p=0.05), while each 1 unit BMI gain among underweight participants was associated with 9.32 mg/L decrease in CRP (p=0.001).CONCLUSIONBeing either overweight or underweight at ART initiation was associated with heightened systemic inflammation. While weight gain among overweight/obese persons predicted increased inflammation, weight gain among underweight persons predicted reduced inflammation.
AB - BACKGROUNDBoth wasting and obesity are associated with inflammation, but the extent to which body weight changes influence inflammation in HIV is unknown.METHODSAmong a random virologically suppressed participants of the PEARLS trial, inflammatory markers were measured at weeks 0, 24, and 48 post-antiretroviral therapy (ART). Associations between baseline and change in body mass index (BMI) and inflammation changes were assessed using random effects models.RESULTSOf 246 participants, 27% were overweight/obese (BMI≥25 kg/m(2)) and 8% were underweight (BMI<18.5 kg/m(2)) at baseline. After 48 weeks, 37% were overweight/obese and 3% were underweight. While many inflammatory markers decreased 48 weeks after ART in the overall group, the decrease in CRP was smaller in overweight/obese participants (p=0.01) and the decreases in both CRP (p=0.01) and IL-18 (p=0.02) were smaller in underweight participants. Each 1 unit gain in BMI among overweight/obese participants was associated with a 0.02 log10 increase in sCD14 (p=0.05), while each 1 unit BMI gain among underweight participants was associated with 9.32 mg/L decrease in CRP (p=0.001).CONCLUSIONBeing either overweight or underweight at ART initiation was associated with heightened systemic inflammation. While weight gain among overweight/obese persons predicted increased inflammation, weight gain among underweight persons predicted reduced inflammation.
KW - body mass index
KW - HAART clinical outcomes
KW - HIV/AIDS
KW - immune activation/inflammation
KW - noncommunicable diseases
U2 - 10.1093/infdis/jiw096
DO - 10.1093/infdis/jiw096
M3 - Article
SN - 0022-1899
VL - 214
SP - 65
EP - 72
JO - Journal of Infectious Diseases
JF - Journal of Infectious Diseases
IS - 1
ER -
