Inflammasome Contribution to the Activation of Th1, Th2, and Th17 Immune Responses

Ekaterina Martynova; Albert Rizvanov; Richard A. Urbanowicz; Svetlana Khaiboullina

doi:10.3389/fmicb.2022.851835

Inflammasome Contribution to the Activation of Th1, Th2, and Th17 Immune Responses

Ekaterina Martynova
, Albert Rizvanov
, Richard A. Urbanowicz
, Svetlana Khaiboullina

Kazan Volga Region Federal University
University of Liverpool

Research output: Contribution to journal › Review article › peer-review

47 Citations (Scopus)

Abstract

Inflammasomes are cytosolic polyprotein complexes formed in response to various external and internal stimuli, including viral and bacterial antigens. The main product of the inflammasome is active caspase 1 which proteolytically cleaves, releasing functional interleukin-1 beta (IL-1β) and interleukin-18 (IL-18). These cytokines play a central role in shaping immune response to pathogens. In this review, we will focus on the mechanisms of inflammasome activation, as well as their role in development of Th1, Th2, and Th17 lymphocytes. The contribution of cytokines IL-1β, IL-18, and IL-33, products of activated inflammasomes, are summarized. Additionally, the role of cytokines released from tissue cells in promoting differentiation of lymphocyte populations is discussed.

Original language	English
Article number	851835
Journal	Frontiers in Microbiology
Volume	13
DOIs	https://doi.org/10.3389/fmicb.2022.851835
Publication status	Published - 17 Mar 2022
Externally published	Yes

Keywords

immune response
inflammasome
Th1
Th17
Th2

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10.3389/fmicb.2022.851835Licence: CC BY

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title = "Inflammasome Contribution to the Activation of Th1, Th2, and Th17 Immune Responses",

abstract = "Inflammasomes are cytosolic polyprotein complexes formed in response to various external and internal stimuli, including viral and bacterial antigens. The main product of the inflammasome is active caspase 1 which proteolytically cleaves, releasing functional interleukin-1 beta (IL-1β) and interleukin-18 (IL-18). These cytokines play a central role in shaping immune response to pathogens. In this review, we will focus on the mechanisms of inflammasome activation, as well as their role in development of Th1, Th2, and Th17 lymphocytes. The contribution of cytokines IL-1β, IL-18, and IL-33, products of activated inflammasomes, are summarized. Additionally, the role of cytokines released from tissue cells in promoting differentiation of lymphocyte populations is discussed.",

keywords = "immune response, inflammasome, Th1, Th17, Th2",

author = "Ekaterina Martynova and Albert Rizvanov and Urbanowicz, \{Richard A.\} and Svetlana Khaiboullina",

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doi = "10.3389/fmicb.2022.851835",

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TY - JOUR

T1 - Inflammasome Contribution to the Activation of Th1, Th2, and Th17 Immune Responses

AU - Martynova, Ekaterina

AU - Rizvanov, Albert

AU - Urbanowicz, Richard A.

AU - Khaiboullina, Svetlana

PY - 2022/3/17

Y1 - 2022/3/17

N2 - Inflammasomes are cytosolic polyprotein complexes formed in response to various external and internal stimuli, including viral and bacterial antigens. The main product of the inflammasome is active caspase 1 which proteolytically cleaves, releasing functional interleukin-1 beta (IL-1β) and interleukin-18 (IL-18). These cytokines play a central role in shaping immune response to pathogens. In this review, we will focus on the mechanisms of inflammasome activation, as well as their role in development of Th1, Th2, and Th17 lymphocytes. The contribution of cytokines IL-1β, IL-18, and IL-33, products of activated inflammasomes, are summarized. Additionally, the role of cytokines released from tissue cells in promoting differentiation of lymphocyte populations is discussed.

AB - Inflammasomes are cytosolic polyprotein complexes formed in response to various external and internal stimuli, including viral and bacterial antigens. The main product of the inflammasome is active caspase 1 which proteolytically cleaves, releasing functional interleukin-1 beta (IL-1β) and interleukin-18 (IL-18). These cytokines play a central role in shaping immune response to pathogens. In this review, we will focus on the mechanisms of inflammasome activation, as well as their role in development of Th1, Th2, and Th17 lymphocytes. The contribution of cytokines IL-1β, IL-18, and IL-33, products of activated inflammasomes, are summarized. Additionally, the role of cytokines released from tissue cells in promoting differentiation of lymphocyte populations is discussed.

KW - immune response

KW - inflammasome

KW - Th1

KW - Th17

KW - Th2

U2 - 10.3389/fmicb.2022.851835

DO - 10.3389/fmicb.2022.851835

M3 - Review article

AN - SCOPUS:85127937257

SN - 1664-302X

VL - 13

JO - Frontiers in Microbiology

JF - Frontiers in Microbiology

M1 - 851835

ER -

Inflammasome Contribution to the Activation of Th1, Th2, and Th17 Immune Responses

Abstract

Keywords

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