Incidence of cardiometabolic diseases in people living with and
without HIV in the UK: a population-based matched cohort study

Tiffany E. Gooden; Mike Gardner; Jingya Wang; Kate Jolly; Deirdre A. Lane; Laura A. Benjamin; Henry Mwandumba; Vanessa Kandoole; Isaac B. Lwanga; Stephen Taylor; Semira Manaseki-Holland; Gregory Y.H. Lip; Krishnarajah Nirantharakumar; G. Neil Thomas

doi:10.1093/infdis/jiab420

Incidence of cardiometabolic diseases in people living with and without HIV in the UK: a population-based matched cohort study

Tiffany E. Gooden, Mike Gardner, Jingya Wang, Kate Jolly, Deirdre A. Lane, Laura A. Benjamin, Henry Mwandumba, Vanessa Kandoole, Isaac B. Lwanga, Stephen Taylor, Semira Manaseki-Holland, Gregory Y.H. Lip, Krishnarajah Nirantharakumar, G. Neil Thomas

Clinical Sciences

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

27 Citations (Scopus)

Abstract

Background

Evidence on the risk of cardiovascular disease (CVD) and CVD risk factors in people with HIV (PWH) is limited. We aimed to identify the risk of composite CVD, individual CVD events and common risk factors.

Methods

This was a nationwide population-based cohort study comparing adult (≥18y) PWH with HIV-negative individuals matched on age, sex, ethnicity and location. The primary outcome was composite CVD comprising stroke, myocardial infarction (MI), peripheral vascular disease (PVD), ischaemic heart disease and heart failure. The secondary outcomes were individual CVD events, hypertension, diabetes, chronic kidney disease (CKD) and all-cause mortality. Cox proportional hazard regression models were used to examine the risk of each outcome.

Results

We identified 9233 PWH and 35721 HIV-negative individuals. An increased risk was found for composite CVD (adjusted hazard ratio [aHR] 1.50, 95% CI 1.28-1.77), stroke (aHR 1.42, 95% CI 1.08-1.86), ischaemic heart disease (aHR 1.55, 95% CI 1.24-1.94), hypertension (aHR 1.37, 95% CI 1.23-1.53), type 2 diabetes (aHR 1.28, 95% CI 1.09-1.50), CKD (aHR 2.42, 95% CI 1.98-2.94) and all-cause mortality (aHR 2.84, 95% CI (2.48-3.25).

Conclusions

PWH have a heightened risk for CVD and common CVD risk factors, reinforcing the importance for regular screening for such conditions.

Original language	English
Title of host publication	Journal of Infectious Diseases
Publisher	Oxford University Press
Pages	1348-1356
Number of pages	9
Volume	225
Edition	8
DOIs	https://doi.org/10.1093/infdis/jiab420
Publication status	Published - 15 Apr 2022

Keywords

cardiovascular disease
comorbidity
HIV
metabolic diseases
multimorbidity

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1093/infdis/jiab420Licence: CC BY-NC-ND

Gooden CVD and HIVAccepted author manuscript, 1.09 MBLicence: CC BY-NC-ND

Cite this

Gooden, T. E., Gardner, M., Wang, J., Jolly, K., Lane, D. A., Benjamin, L. A., Mwandumba, H., Kandoole, V., Lwanga, I. B., Taylor, S., Manaseki-Holland, S., Lip, G. Y. H., Nirantharakumar, K., & Neil Thomas, G. (2022). Incidence of cardiometabolic diseases in people living with and without HIV in the UK: a population-based matched cohort study. In Journal of Infectious Diseases (8 ed., Vol. 225, pp. 1348-1356). Oxford University Press. https://doi.org/10.1093/infdis/jiab420

@inproceedings{6af4d4a9824d4689bbee26f05cb1224b,

title = "Incidence of cardiometabolic diseases in people living with and without HIV in the UK: a population-based matched cohort study",

abstract = "BackgroundEvidence on the risk of cardiovascular disease (CVD) and CVD risk factors in people with HIV (PWH) is limited. We aimed to identify the risk of composite CVD, individual CVD events and common risk factors.MethodsThis was a nationwide population-based cohort study comparing adult (≥18y) PWH with HIV-negative individuals matched on age, sex, ethnicity and location. The primary outcome was composite CVD comprising stroke, myocardial infarction (MI), peripheral vascular disease (PVD), ischaemic heart disease and heart failure. The secondary outcomes were individual CVD events, hypertension, diabetes, chronic kidney disease (CKD) and all-cause mortality. Cox proportional hazard regression models were used to examine the risk of each outcome.ResultsWe identified 9233 PWH and 35721 HIV-negative individuals. An increased risk was found for composite CVD (adjusted hazard ratio [aHR] 1.50, 95% CI 1.28-1.77), stroke (aHR 1.42, 95% CI 1.08-1.86), ischaemic heart disease (aHR 1.55, 95% CI 1.24-1.94), hypertension (aHR 1.37, 95% CI 1.23-1.53), type 2 diabetes (aHR 1.28, 95% CI 1.09-1.50), CKD (aHR 2.42, 95% CI 1.98-2.94) and all-cause mortality (aHR 2.84, 95% CI (2.48-3.25).ConclusionsPWH have a heightened risk for CVD and common CVD risk factors, reinforcing the importance for regular screening for such conditions.",

keywords = "cardiovascular disease, comorbidity, HIV, metabolic diseases, multimorbidity",

author = "Gooden, {Tiffany E.} and Mike Gardner and Jingya Wang and Kate Jolly and Lane, {Deirdre A.} and Benjamin, {Laura A.} and Henry Mwandumba and Vanessa Kandoole and Lwanga, {Isaac B.} and Stephen Taylor and Semira Manaseki-Holland and Lip, {Gregory Y.H.} and Krishnarajah Nirantharakumar and {Neil Thomas}, G.",

year = "2022",

month = apr,

day = "15",

doi = "10.1093/infdis/jiab420",

language = "English",

volume = "225",

pages = "1348--1356",

booktitle = "Journal of Infectious Diseases",

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Gooden, TE, Gardner, M, Wang, J, Jolly, K, Lane, DA, Benjamin, LA, Mwandumba, H, Kandoole, V, Lwanga, IB, Taylor, S, Manaseki-Holland, S, Lip, GYH, Nirantharakumar, K & Neil Thomas, G 2022, Incidence of cardiometabolic diseases in people living with and without HIV in the UK: a population-based matched cohort study. in Journal of Infectious Diseases. 8 edn, vol. 225, Oxford University Press, pp. 1348-1356. https://doi.org/10.1093/infdis/jiab420

Incidence of cardiometabolic diseases in people living with and without HIV in the UK: a population-based matched cohort study. / Gooden, Tiffany E.; Gardner, Mike; Wang, Jingya et al.
Journal of Infectious Diseases. Vol. 225 8. ed. Oxford University Press, 2022. p. 1348-1356.

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

TY - GEN

T1 - Incidence of cardiometabolic diseases in people living with and without HIV in the UK: a population-based matched cohort study

AU - Gooden, Tiffany E.

AU - Gardner, Mike

AU - Wang, Jingya

AU - Jolly, Kate

AU - Lane, Deirdre A.

AU - Benjamin, Laura A.

AU - Mwandumba, Henry

AU - Kandoole, Vanessa

AU - Lwanga, Isaac B.

AU - Taylor, Stephen

AU - Manaseki-Holland, Semira

AU - Lip, Gregory Y.H.

AU - Nirantharakumar, Krishnarajah

AU - Neil Thomas, G.

PY - 2022/4/15

Y1 - 2022/4/15

N2 - BackgroundEvidence on the risk of cardiovascular disease (CVD) and CVD risk factors in people with HIV (PWH) is limited. We aimed to identify the risk of composite CVD, individual CVD events and common risk factors.MethodsThis was a nationwide population-based cohort study comparing adult (≥18y) PWH with HIV-negative individuals matched on age, sex, ethnicity and location. The primary outcome was composite CVD comprising stroke, myocardial infarction (MI), peripheral vascular disease (PVD), ischaemic heart disease and heart failure. The secondary outcomes were individual CVD events, hypertension, diabetes, chronic kidney disease (CKD) and all-cause mortality. Cox proportional hazard regression models were used to examine the risk of each outcome.ResultsWe identified 9233 PWH and 35721 HIV-negative individuals. An increased risk was found for composite CVD (adjusted hazard ratio [aHR] 1.50, 95% CI 1.28-1.77), stroke (aHR 1.42, 95% CI 1.08-1.86), ischaemic heart disease (aHR 1.55, 95% CI 1.24-1.94), hypertension (aHR 1.37, 95% CI 1.23-1.53), type 2 diabetes (aHR 1.28, 95% CI 1.09-1.50), CKD (aHR 2.42, 95% CI 1.98-2.94) and all-cause mortality (aHR 2.84, 95% CI (2.48-3.25).ConclusionsPWH have a heightened risk for CVD and common CVD risk factors, reinforcing the importance for regular screening for such conditions.

AB - BackgroundEvidence on the risk of cardiovascular disease (CVD) and CVD risk factors in people with HIV (PWH) is limited. We aimed to identify the risk of composite CVD, individual CVD events and common risk factors.MethodsThis was a nationwide population-based cohort study comparing adult (≥18y) PWH with HIV-negative individuals matched on age, sex, ethnicity and location. The primary outcome was composite CVD comprising stroke, myocardial infarction (MI), peripheral vascular disease (PVD), ischaemic heart disease and heart failure. The secondary outcomes were individual CVD events, hypertension, diabetes, chronic kidney disease (CKD) and all-cause mortality. Cox proportional hazard regression models were used to examine the risk of each outcome.ResultsWe identified 9233 PWH and 35721 HIV-negative individuals. An increased risk was found for composite CVD (adjusted hazard ratio [aHR] 1.50, 95% CI 1.28-1.77), stroke (aHR 1.42, 95% CI 1.08-1.86), ischaemic heart disease (aHR 1.55, 95% CI 1.24-1.94), hypertension (aHR 1.37, 95% CI 1.23-1.53), type 2 diabetes (aHR 1.28, 95% CI 1.09-1.50), CKD (aHR 2.42, 95% CI 1.98-2.94) and all-cause mortality (aHR 2.84, 95% CI (2.48-3.25).ConclusionsPWH have a heightened risk for CVD and common CVD risk factors, reinforcing the importance for regular screening for such conditions.

KW - cardiovascular disease

KW - comorbidity

KW - HIV

KW - metabolic diseases

KW - multimorbidity

U2 - 10.1093/infdis/jiab420

DO - 10.1093/infdis/jiab420

M3 - Conference contribution

VL - 225

SP - 1348

EP - 1356

BT - Journal of Infectious Diseases

PB - Oxford University Press

ER -