Inactivation of HCV and HIV by microwave: A novel approach for prevention of virus transmission among people who inject drugs: A novel approach for prevention of virus transmission among people who inject drugs

Anindya Siddharta; Stephanie Pfaender; Angelina Malassa; Juliane Doerrbecker; A. Anggakusuma; Michael Engelmann; Boya Nugraha; Joerg Steinmann; Daniel Todt; Florian W.R. Vondran; Pedro Mateu-Gelabert; Christine Goffinet; Eike Steinmann

doi:10.1038/srep36619

Inactivation of HCV and HIV by microwave: A novel approach for prevention of virus transmission among people who inject drugs: A novel approach for prevention of virus transmission among people who inject drugs

Anindya Siddharta
, Stephanie Pfaender
, Angelina Malassa
, Juliane Doerrbecker
, A. Anggakusuma
, Michael Engelmann
, Boya Nugraha
, Joerg Steinmann
, Daniel Todt
, Florian W.R. Vondran
, Pedro Mateu-Gelabert
, Christine Goffinet
, Eike Steinmann

TWINCORE
Hannover Medical School
University of Duisburg-Essen
National Development and Research Institutes, Inc.

Research output: Contribution to journal › Article › peer-review

18 Citations (Scopus)

Abstract

Hepatitis C virus (HCV) and human immunodeficiency virus (HIV-1) transmissions among people who inject drugs (PWID) continue to pose a challenging global health problem. Here, we aimed to analyse a universally applicable inactivation procedure, namely microwave irradiation, as a safe and effective method to reduce the risk of viral transmission. The exposure of HCV from different genotypes to microwave irradiation resulted in a significant reduction of viral infectivity. Furthermore, microwave irradiation reduced viral infectivity of HIV-1 and of HCV/HIV-1 suspensions indicating that this inactivation may be effective at preventing co-infections. To translate microwave irradiation as prevention method to used drug preparation equipment, we could further show that HCV as well as HIV-1 infectivity could be abrogated in syringes and filters. This study demonstrates the power of microwave irradiation for the reduction of viral transmission and establishment of this safety strategy could help reduce the transmission of blood-borne viruses.

Original language	English
Article number	36619
Journal	Scientific Reports
Volume	6
DOIs	https://doi.org/10.1038/srep36619
Publication status	Published - 18 Nov 2016
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Access to Document

10.1038/srep36619Licence: CC BY

Fingerprint

Dive into the research topics of 'Inactivation of HCV and HIV by microwave: A novel approach for prevention of virus transmission among people who inject drugs: A novel approach for prevention of virus transmission among people who inject drugs'. Together they form a unique fingerprint.

Cite this

Siddharta, A., Pfaender, S., Malassa, A., Doerrbecker, J., Anggakusuma, A., Engelmann, M., Nugraha, B., Steinmann, J., Todt, D., Vondran, F. W. R., Mateu-Gelabert, P., Goffinet, C., & Steinmann, E. (2016). Inactivation of HCV and HIV by microwave: A novel approach for prevention of virus transmission among people who inject drugs: A novel approach for prevention of virus transmission among people who inject drugs. Scientific Reports, 6, Article 36619. https://doi.org/10.1038/srep36619

@article{7eba565c23be403e9cdac4547dc70d38,

title = "Inactivation of HCV and HIV by microwave: A novel approach for prevention of virus transmission among people who inject drugs: A novel approach for prevention of virus transmission among people who inject drugs",

abstract = "Hepatitis C virus (HCV) and human immunodeficiency virus (HIV-1) transmissions among people who inject drugs (PWID) continue to pose a challenging global health problem. Here, we aimed to analyse a universally applicable inactivation procedure, namely microwave irradiation, as a safe and effective method to reduce the risk of viral transmission. The exposure of HCV from different genotypes to microwave irradiation resulted in a significant reduction of viral infectivity. Furthermore, microwave irradiation reduced viral infectivity of HIV-1 and of HCV/HIV-1 suspensions indicating that this inactivation may be effective at preventing co-infections. To translate microwave irradiation as prevention method to used drug preparation equipment, we could further show that HCV as well as HIV-1 infectivity could be abrogated in syringes and filters. This study demonstrates the power of microwave irradiation for the reduction of viral transmission and establishment of this safety strategy could help reduce the transmission of blood-borne viruses.",

author = "Anindya Siddharta and Stephanie Pfaender and Angelina Malassa and Juliane Doerrbecker and A. Anggakusuma and Michael Engelmann and Boya Nugraha and Joerg Steinmann and Daniel Todt and Vondran, \{Florian W.R.\} and Pedro Mateu-Gelabert and Christine Goffinet and Eike Steinmann",

year = "2016",

month = nov,

day = "18",

doi = "10.1038/srep36619",

language = "English",

volume = "6",

journal = "Scientific Reports",

issn = "2045-2322",

publisher = "Nature Research",

}

Siddharta, A, Pfaender, S, Malassa, A, Doerrbecker, J, Anggakusuma, A, Engelmann, M, Nugraha, B, Steinmann, J, Todt, D, Vondran, FWR, Mateu-Gelabert, P, Goffinet, C & Steinmann, E 2016, 'Inactivation of HCV and HIV by microwave: A novel approach for prevention of virus transmission among people who inject drugs: A novel approach for prevention of virus transmission among people who inject drugs', Scientific Reports, vol. 6, 36619. https://doi.org/10.1038/srep36619

Inactivation of HCV and HIV by microwave: A novel approach for prevention of virus transmission among people who inject drugs: A novel approach for prevention of virus transmission among people who inject drugs. / Siddharta, Anindya; Pfaender, Stephanie; Malassa, Angelina et al.
In: Scientific Reports, Vol. 6, 36619, 18.11.2016.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Inactivation of HCV and HIV by microwave: A novel approach for prevention of virus transmission among people who inject drugs: A novel approach for prevention of virus transmission among people who inject drugs

AU - Siddharta, Anindya

AU - Pfaender, Stephanie

AU - Malassa, Angelina

AU - Doerrbecker, Juliane

AU - Anggakusuma, A.

AU - Engelmann, Michael

AU - Nugraha, Boya

AU - Steinmann, Joerg

AU - Todt, Daniel

AU - Vondran, Florian W.R.

AU - Mateu-Gelabert, Pedro

AU - Goffinet, Christine

AU - Steinmann, Eike

PY - 2016/11/18

Y1 - 2016/11/18

N2 - Hepatitis C virus (HCV) and human immunodeficiency virus (HIV-1) transmissions among people who inject drugs (PWID) continue to pose a challenging global health problem. Here, we aimed to analyse a universally applicable inactivation procedure, namely microwave irradiation, as a safe and effective method to reduce the risk of viral transmission. The exposure of HCV from different genotypes to microwave irradiation resulted in a significant reduction of viral infectivity. Furthermore, microwave irradiation reduced viral infectivity of HIV-1 and of HCV/HIV-1 suspensions indicating that this inactivation may be effective at preventing co-infections. To translate microwave irradiation as prevention method to used drug preparation equipment, we could further show that HCV as well as HIV-1 infectivity could be abrogated in syringes and filters. This study demonstrates the power of microwave irradiation for the reduction of viral transmission and establishment of this safety strategy could help reduce the transmission of blood-borne viruses.

AB - Hepatitis C virus (HCV) and human immunodeficiency virus (HIV-1) transmissions among people who inject drugs (PWID) continue to pose a challenging global health problem. Here, we aimed to analyse a universally applicable inactivation procedure, namely microwave irradiation, as a safe and effective method to reduce the risk of viral transmission. The exposure of HCV from different genotypes to microwave irradiation resulted in a significant reduction of viral infectivity. Furthermore, microwave irradiation reduced viral infectivity of HIV-1 and of HCV/HIV-1 suspensions indicating that this inactivation may be effective at preventing co-infections. To translate microwave irradiation as prevention method to used drug preparation equipment, we could further show that HCV as well as HIV-1 infectivity could be abrogated in syringes and filters. This study demonstrates the power of microwave irradiation for the reduction of viral transmission and establishment of this safety strategy could help reduce the transmission of blood-borne viruses.

U2 - 10.1038/srep36619

DO - 10.1038/srep36619

M3 - Article

SN - 2045-2322

VL - 6

JO - Scientific Reports

JF - Scientific Reports

M1 - 36619

ER -