Implications of insecticide resistance for malaria vector control with long-lasting insecticidal nets: evidence from health facility data from Benin

Filémon T. Tokponnon; Yolande Sissinto; Aurore Hounto Ogouyémi; Adicath Adéola Adéothy; Alioun Adechoubou; Télesphore Houansou; Mariam Oke; Dorothée Kinde-Gazard; Achille Massougbodji; Martin C. Akogbeto; Sylvie Cornelie; Vincent Corbel; Tessa B. Knox; Abraham Peter Mnzava; Martin Donnelly; Immo Kleinschmidt; John Bradley

doi:10.1186/s12936-019-2656-7

Implications of insecticide resistance for malaria vector control with long-lasting insecticidal nets: evidence from health facility data from Benin

Filémon T. Tokponnon
, Yolande Sissinto
, Aurore Hounto Ogouyémi
, Adicath Adéola Adéothy
, Alioun Adechoubou
, Télesphore Houansou
, Mariam Oke
, Dorothée Kinde-Gazard
, Achille Massougbodji
, Martin C. Akogbeto
, Sylvie Cornelie
, Vincent Corbel
, Tessa B. Knox
, Abraham Peter Mnzava
, Martin Donnelly
, Immo Kleinschmidt
, John Bradley

Vector Biology

National Malaria Control Programme
Ministry of Health
Université d'Abomey-Calavi
World Health Organization
Centre de recherche entomologique de Cotonou
Université Montpellier
African Leaders Malaria Alliance
London School of Hygiene and Tropical Medicine

Research output: Contribution to journal › Article › peer-review

23 Citations (Scopus)

Abstract

Background

Insecticide-based interventions have averted more than 500 million malaria cases since 2000, but insecticide resistance in mosquitoes could bring about a rebound in disease and mortality. This study investigated whether insecticide resistance was associated with increased incidence of clinical malaria.

Methods

In an area of southern Benin with insecticide resistance and high use of insecticide-treated nets (ITNs), malaria morbidity and insecticide resistance were measured simultaneously in 30 clusters (villages or collections of villages) multiple times over the course of 2 years. Insecticide resistance frequencies were measured using the standard World Health Organization bioassay test. Malaria morbidity was measured by cases recorded at health facilities both in the whole population using routinely collected data and in a passively followed cohort of children under 5 years old.

Results

There was no evidence that incidence of malaria from routinely collected data was higher in clusters with resistance frequencies above the median, either in children aged under 5 (RR = 1.27 (95% CI 0.81–2.00) p = 0.276) or in individuals aged 5 or over (RR = 1.74 (95% CI 0.91–3.34) p = 0.093). There was also no evidence that incidence was higher in clusters with resistance frequencies above the median in the passively followed cohort (RR = 1.11 (0.52–2.35) p = 0.777).

Conclusions

This study found no association between frequency of resistance and incidence of clinical malaria in an area where ITNs are the principal form of vector control. This may be because, as other studies have shown, ITNs continue to offer some protection from malaria even in the presence of insecticide resistance. Irrespective of resistance, nets provide only partial protection so the development of improved or supplementary vector control tools is required to reduce Africa’s unacceptably high malaria burden.

Original language	English
Article number	37
Pages (from-to)	e37
Journal	Malaria Journal
Volume	18
Issue number	1
DOIs	https://doi.org/10.1186/s12936-019-2656-7
Publication status	Published - 11 Feb 2019

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Insecticide
Malaria
Pyrethroid
Resistance
Vector

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10.1186/s12936-019-2656-7Licence: CC BY

Implications of insecticide resistance for malaria vector control with long-lastinFinal published version, 1.28 MBLicence: CC BY

Cite this

Tokponnon, F. T., Sissinto, Y., Ogouyémi, A. H., Adéothy, A. A., Adechoubou, A., Houansou, T., Oke, M., Kinde-Gazard, D., Massougbodji, A., Akogbeto, M. C., Cornelie, S., Corbel, V., Knox, T. B., Mnzava, A. P., Donnelly, M., Kleinschmidt, I., & Bradley, J. (2019). Implications of insecticide resistance for malaria vector control with long-lasting insecticidal nets: evidence from health facility data from Benin. Malaria Journal, 18(1), e37. Article 37. https://doi.org/10.1186/s12936-019-2656-7

@article{df20b15e787b460e9ce3841feaf5f335,

title = "Implications of insecticide resistance for malaria vector control with long-lasting insecticidal nets: evidence from health facility data from Benin",

abstract = "BackgroundInsecticide-based interventions have averted more than 500 million malaria cases since 2000, but insecticide resistance in mosquitoes could bring about a rebound in disease and mortality. This study investigated whether insecticide resistance was associated with increased incidence of clinical malaria.MethodsIn an area of southern Benin with insecticide resistance and high use of insecticide-treated nets (ITNs), malaria morbidity and insecticide resistance were measured simultaneously in 30 clusters (villages or collections of villages) multiple times over the course of 2 years. Insecticide resistance frequencies were measured using the standard World Health Organization bioassay test. Malaria morbidity was measured by cases recorded at health facilities both in the whole population using routinely collected data and in a passively followed cohort of children under 5 years old.ResultsThere was no evidence that incidence of malaria from routinely collected data was higher in clusters with resistance frequencies above the median, either in children aged under 5 (RR = 1.27 (95\% CI 0.81–2.00) p = 0.276) or in individuals aged 5 or over (RR = 1.74 (95\% CI 0.91–3.34) p = 0.093). There was also no evidence that incidence was higher in clusters with resistance frequencies above the median in the passively followed cohort (RR = 1.11 (0.52–2.35) p = 0.777).ConclusionsThis study found no association between frequency of resistance and incidence of clinical malaria in an area where ITNs are the principal form of vector control. This may be because, as other studies have shown, ITNs continue to offer some protection from malaria even in the presence of insecticide resistance. Irrespective of resistance, nets provide only partial protection so the development of improved or supplementary vector control tools is required to reduce Africa{\textquoteright}s unacceptably high malaria burden.",

keywords = "Insecticide, Malaria, Pyrethroid, Resistance, Vector",

author = "Tokponnon, \{Fil{\'e}mon T.\} and Yolande Sissinto and Ogouy{\'e}mi, \{Aurore Hounto\} and Ad{\'e}othy, \{Adicath Ad{\'e}ola\} and Alioun Adechoubou and T{\'e}lesphore Houansou and Mariam Oke and Doroth{\'e}e Kinde-Gazard and Achille Massougbodji and Akogbeto, \{Martin C.\} and Sylvie Cornelie and Vincent Corbel and Knox, \{Tessa B.\} and Mnzava, \{Abraham Peter\} and Martin Donnelly and Immo Kleinschmidt and John Bradley",

year = "2019",

month = feb,

day = "11",

doi = "10.1186/s12936-019-2656-7",

language = "English",

volume = "18",

pages = "e37",

journal = "Malaria Journal",

issn = "1475-2875",

publisher = "BioMed Central Ltd",

number = "1",

}

Tokponnon, FT, Sissinto, Y, Ogouyémi, AH, Adéothy, AA, Adechoubou, A, Houansou, T, Oke, M, Kinde-Gazard, D, Massougbodji, A, Akogbeto, MC, Cornelie, S, Corbel, V, Knox, TB, Mnzava, AP, Donnelly, M, Kleinschmidt, I & Bradley, J 2019, 'Implications of insecticide resistance for malaria vector control with long-lasting insecticidal nets: evidence from health facility data from Benin', Malaria Journal, vol. 18, no. 1, 37, pp. e37. https://doi.org/10.1186/s12936-019-2656-7

TY - JOUR

T1 - Implications of insecticide resistance for malaria vector control with long-lasting insecticidal nets: evidence from health facility data from Benin

AU - Tokponnon, Filémon T.

AU - Sissinto, Yolande

AU - Ogouyémi, Aurore Hounto

AU - Adéothy, Adicath Adéola

AU - Adechoubou, Alioun

AU - Houansou, Télesphore

AU - Oke, Mariam

AU - Kinde-Gazard, Dorothée

AU - Massougbodji, Achille

AU - Akogbeto, Martin C.

AU - Cornelie, Sylvie

AU - Corbel, Vincent

AU - Knox, Tessa B.

AU - Mnzava, Abraham Peter

AU - Donnelly, Martin

AU - Kleinschmidt, Immo

AU - Bradley, John

PY - 2019/2/11

Y1 - 2019/2/11

N2 - BackgroundInsecticide-based interventions have averted more than 500 million malaria cases since 2000, but insecticide resistance in mosquitoes could bring about a rebound in disease and mortality. This study investigated whether insecticide resistance was associated with increased incidence of clinical malaria.MethodsIn an area of southern Benin with insecticide resistance and high use of insecticide-treated nets (ITNs), malaria morbidity and insecticide resistance were measured simultaneously in 30 clusters (villages or collections of villages) multiple times over the course of 2 years. Insecticide resistance frequencies were measured using the standard World Health Organization bioassay test. Malaria morbidity was measured by cases recorded at health facilities both in the whole population using routinely collected data and in a passively followed cohort of children under 5 years old.ResultsThere was no evidence that incidence of malaria from routinely collected data was higher in clusters with resistance frequencies above the median, either in children aged under 5 (RR = 1.27 (95% CI 0.81–2.00) p = 0.276) or in individuals aged 5 or over (RR = 1.74 (95% CI 0.91–3.34) p = 0.093). There was also no evidence that incidence was higher in clusters with resistance frequencies above the median in the passively followed cohort (RR = 1.11 (0.52–2.35) p = 0.777).ConclusionsThis study found no association between frequency of resistance and incidence of clinical malaria in an area where ITNs are the principal form of vector control. This may be because, as other studies have shown, ITNs continue to offer some protection from malaria even in the presence of insecticide resistance. Irrespective of resistance, nets provide only partial protection so the development of improved or supplementary vector control tools is required to reduce Africa’s unacceptably high malaria burden.

AB - BackgroundInsecticide-based interventions have averted more than 500 million malaria cases since 2000, but insecticide resistance in mosquitoes could bring about a rebound in disease and mortality. This study investigated whether insecticide resistance was associated with increased incidence of clinical malaria.MethodsIn an area of southern Benin with insecticide resistance and high use of insecticide-treated nets (ITNs), malaria morbidity and insecticide resistance were measured simultaneously in 30 clusters (villages or collections of villages) multiple times over the course of 2 years. Insecticide resistance frequencies were measured using the standard World Health Organization bioassay test. Malaria morbidity was measured by cases recorded at health facilities both in the whole population using routinely collected data and in a passively followed cohort of children under 5 years old.ResultsThere was no evidence that incidence of malaria from routinely collected data was higher in clusters with resistance frequencies above the median, either in children aged under 5 (RR = 1.27 (95% CI 0.81–2.00) p = 0.276) or in individuals aged 5 or over (RR = 1.74 (95% CI 0.91–3.34) p = 0.093). There was also no evidence that incidence was higher in clusters with resistance frequencies above the median in the passively followed cohort (RR = 1.11 (0.52–2.35) p = 0.777).ConclusionsThis study found no association between frequency of resistance and incidence of clinical malaria in an area where ITNs are the principal form of vector control. This may be because, as other studies have shown, ITNs continue to offer some protection from malaria even in the presence of insecticide resistance. Irrespective of resistance, nets provide only partial protection so the development of improved or supplementary vector control tools is required to reduce Africa’s unacceptably high malaria burden.

KW - Insecticide

KW - Malaria

KW - Pyrethroid

KW - Resistance

KW - Vector

U2 - 10.1186/s12936-019-2656-7

DO - 10.1186/s12936-019-2656-7

M3 - Article

SN - 1475-2875

VL - 18

SP - e37

JO - Malaria Journal

JF - Malaria Journal

IS - 1

M1 - 37

ER -

Implications of insecticide resistance for malaria vector control with long-lasting insecticidal nets: evidence from health facility data from Benin

Abstract

UN SDGs

Keywords

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