Impact of maternal body mass index and gestational weight gain on pregnancy complications: An individual participant data meta-analysis of European, North American and Australian cohorts.

S. Santos; E. Voerman; P. Amiano; H. Barros; L. J. Beilin; A. Bergström; M. A. Charles; L. Chatzi; C. Chevrier; G. P. Chrousos; E. Corpeleijn; O. Costa; N. Costet; S. Crozier; Graham Devereux; M. Doyon; M. Eggesbø; M. P. Fantini; S. Farchi; F. Forastiere; V. Georgiu; K. M. Godfrey; D. Gori; V. Grote; W. Hanke; I. Hertz-Picciotto; B. Heude; M. F. Hivert; D. Hryhorczuk; R. C. Huang; H. Inskip; A. M. Karvonen; L. C. Kenny; B. Koletzko; L. K. Küpers; H. Lagström; I. Lehmann; P. Magnus; R. Majewska; J. Mäkelä; Y. Manios; F. M. McAuliffe; S. W. McDonald; J. Mehegan; E. Melén; M. Mommers; C. S. Morgen; G. Moschonis; D. Murray; C. Ní Chaoimh; E. A. Nohr; A. M. Nybo Andersen; E. Oken; A. J.J.M. Oostvogels; A. Pac; E. Papadopoulou; J. Pekkanen; C. Pizzi; K. Polanska; D. Porta; L. Richiardi; S. L. Rifas-Shiman; N. Roeleveld; L. Ronfani; A. C. Santos; M. Standl; H. Stigum; C. Stoltenberg; E. Thiering; C. Thijs; M. Torrent; S. C. Tough; T. Trnovec; S. Turner; M. M.H.J. van Gelder; L. van Rossem; A. von Berg; M. Vrijheid; T. G.M. Vrijkotte; J. West; A. H. Wijga; J. Wright; O. Zvinchuk; T. I.A. Sørensen; D. A. Lawlor; R. Gaillard; V. W.V. Jaddoe

doi:10.1111/1471-0528.15661

Impact of maternal body mass index and gestational weight gain on pregnancy complications: An individual participant data meta-analysis of European, North American and Australian cohorts.

S. Santos
, E. Voerman
, P. Amiano
, H. Barros
, L. J. Beilin
, A. Bergström
, M. A. Charles
, L. Chatzi
, C. Chevrier
, G. P. Chrousos
, E. Corpeleijn
, O. Costa
, N. Costet
, S. Crozier
, Graham Devereux
, M. Doyon
, M. Eggesbø
, M. P. Fantini
, S. Farchi
, F. Forastiere

V. Georgiu, K. M. Godfrey, D. Gori, V. Grote, W. Hanke, I. Hertz-Picciotto, B. Heude, M. F. Hivert, D. Hryhorczuk, R. C. Huang, H. Inskip, A. M. Karvonen, L. C. Kenny, B. Koletzko, L. K. Küpers, H. Lagström, I. Lehmann, P. Magnus, R. Majewska, J. Mäkelä, Y. Manios, F. M. McAuliffe, S. W. McDonald, J. Mehegan, E. Melén, M. Mommers, C. S. Morgen, G. Moschonis, D. Murray, C. Ní Chaoimh, E. A. Nohr, A. M. Nybo Andersen, E. Oken, A. J.J.M. Oostvogels, A. Pac, E. Papadopoulou, J. Pekkanen, C. Pizzi, K. Polanska, D. Porta, L. Richiardi, S. L. Rifas-Shiman, N. Roeleveld, L. Ronfani, A. C. Santos, M. Standl, H. Stigum, C. Stoltenberg, E. Thiering, C. Thijs, M. Torrent, S. C. Tough, T. Trnovec, S. Turner, M. M.H.J. van Gelder, L. van Rossem, A. von Berg, M. Vrijheid, T. G.M. Vrijkotte, J. West, A. H. Wijga, J. Wright, O. Zvinchuk, T. I.A. Sørensen, D. A. Lawlor, R. Gaillard, V. W.V. Jaddoe

Clinical Sciences

Erasmus University Rotterdam
Public Health Division of Gipuzkoa
Instituto de Investigación Sanitaria Biodonostia
Instituto de Salud Carlos III
University of Porto
Royal Perth Hospital
Karolinska Institutet
Stockholm County Council
Institut national de la santé et de la recherche médicale
Université Paris Cité
University of Southern California
University of Crete
Maastricht University
Irset–Research Institute for Environmental and Occupational Health
National and Kapodistrian University of Athens
University of Groningen
University of Valencia
MRC Lifecourse Epidemiology Unit
Centre Hospitalier Universitaire de Sherbrooke
Norwegian Institute of Public Health
University of Bologna
Department of Epidemiology Lazio Regional Health Service
University Hospital Southampton NHS Foundation Trust
Ludwig Maximilian University of Munich
Nofer Institute of Occupational Medicine
University of California at Davis
Harvard University
Massachusetts General Hospital
University of Illinois at Chicago
the University of Western Australia
National Institute for Health and Welfare
University College Cork, Cork University Maternity Hospital
University of Bristol
Wageningen University & Research
University of Turku
Helmholtz Centre for Environmental Research
Jagiellonian University Medical College
Harokopio University
University College Dublin
University of Calgary
University of Southern Denmark
University of Copenhagen
La Trobe University
University College Cork
Academic Medical Center
University of Helsinki
University of Turin
Radboud University Nijmegen
IRCCS Ospedale Infantile Burlo Garofolo - Trieste
Helmholtz Zentrum München - German Research Center for Environmental Health
University of Bergen
Balearic Islands Health Service
Slovak Medical University
NHS Grampian
Utrecht University
Marien-Hospital Wesel
Universitat de Barcelona
Pompeu Fabra University
Bradford Teaching Hospitals NHS Foundation Trust
National Institute of Public Health and the Environment
Institute of Pediatrics, Obstetrics and Gynecology

Research output: Contribution to journal › Article › peer-review

518 Citations (Scopus)

Abstract

OBJECTIVE

To assess the separate and combined associations of maternal pre-pregnancy BMI and gestational weight gain with the risks of pregnancy complications and their population impact.

DESIGN

Individual participant data meta-analysis of 39 cohorts.

SETTING

Europe, North America and Oceania.

POPULATION

265,270 births.

METHODS

Information on maternal pre-pregnancy BMI, gestational weight gain, and pregnancy complications was obtained. Multilevel binary logistic regression models were used.

MAIN OUTCOME MEASURES

Gestational hypertension, pre-eclampsia, gestational diabetes, preterm birth, small and large size for gestational age at birth.

RESULTS

Higher maternal pre-pregnancy BMI and gestational weight gain were, across their full ranges, associated with higher risks of gestational hypertensive disorders, gestational diabetes and large size for gestational age at birth. Preterm birth risk was higher at lower and higher BMI and weight gain. Compared to normal weight mothers with medium gestational weight gain, obese mothers with high gestational weight gain had the highest risk of any pregnancy complication (Odds Ratio 2.51 (95% Confidence Interval 2.31, 2.74)). We estimated that 23.9% of any pregnancy complication was attributable to maternal overweight/obesity and 31.6% of large size for gestational age infants was attributable to excessive gestational weight gain.

CONCLUSIONS

Maternal pre-pregnancy BMI and gestational weight gain are, across their full ranges, associated with the risks of pregnancy complications. Obese mothers with high gestational weight gain are at the highest risk of pregnancy complications. Promoting a healthy pre-pregnancy BMI and gestational weight gain may reduce the burden of pregnancy complications and ultimately the risk of maternal and neonatal morbidity. This article is protected by copyright. All rights reserved.

Original language	English
Pages (from-to)	984-995
Number of pages	12
Journal	BJOG: An International Journal of Obstetrics and Gynaecology
Volume	126
Issue number	8
Early online date	20 Feb 2019
DOIs	https://doi.org/10.1111/1471-0528.15661
Publication status	Published - 1 Jul 2019

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Birthweight
body mass index
pregnancy complications
preterm birth
weight gain

Access to Document

10.1111/1471-0528.15661

IPD meta-analysis pregnancy complications - GDevereuxAccepted author manuscript, 150 KB

Cite this

Santos, S., Voerman, E., Amiano, P., Barros, H., Beilin, L. J., Bergström, A., Charles, M. A., Chatzi, L., Chevrier, C., Chrousos, G. P., Corpeleijn, E., Costa, O., Costet, N., Crozier, S., Devereux, G., Doyon, M., Eggesbø, M., Fantini, M. P., Farchi, S., ... Jaddoe, V. W. V. (2019). Impact of maternal body mass index and gestational weight gain on pregnancy complications: An individual participant data meta-analysis of European, North American and Australian cohorts. BJOG: An International Journal of Obstetrics and Gynaecology, 126(8), 984-995. https://doi.org/10.1111/1471-0528.15661

@article{9d507e191eb24955a75f39386c46346c,

title = "Impact of maternal body mass index and gestational weight gain on pregnancy complications: An individual participant data meta-analysis of European, North American and Australian cohorts.",

abstract = "OBJECTIVETo assess the separate and combined associations of maternal pre-pregnancy BMI and gestational weight gain with the risks of pregnancy complications and their population impact.DESIGNIndividual participant data meta-analysis of 39 cohorts.SETTINGEurope, North America and Oceania.POPULATION265,270 births.METHODSInformation on maternal pre-pregnancy BMI, gestational weight gain, and pregnancy complications was obtained. Multilevel binary logistic regression models were used.MAIN OUTCOME MEASURESGestational hypertension, pre-eclampsia, gestational diabetes, preterm birth, small and large size for gestational age at birth.RESULTSHigher maternal pre-pregnancy BMI and gestational weight gain were, across their full ranges, associated with higher risks of gestational hypertensive disorders, gestational diabetes and large size for gestational age at birth. Preterm birth risk was higher at lower and higher BMI and weight gain. Compared to normal weight mothers with medium gestational weight gain, obese mothers with high gestational weight gain had the highest risk of any pregnancy complication (Odds Ratio 2.51 (95\% Confidence Interval 2.31, 2.74)). We estimated that 23.9\% of any pregnancy complication was attributable to maternal overweight/obesity and 31.6\% of large size for gestational age infants was attributable to excessive gestational weight gain.CONCLUSIONSMaternal pre-pregnancy BMI and gestational weight gain are, across their full ranges, associated with the risks of pregnancy complications. Obese mothers with high gestational weight gain are at the highest risk of pregnancy complications. Promoting a healthy pre-pregnancy BMI and gestational weight gain may reduce the burden of pregnancy complications and ultimately the risk of maternal and neonatal morbidity. This article is protected by copyright. All rights reserved.",

keywords = "Birthweight, body mass index, pregnancy complications, preterm birth, weight gain",

author = "S. Santos and E. Voerman and P. Amiano and H. Barros and Beilin, \{L. J.\} and A. Bergstr{\"o}m and Charles, \{M. A.\} and L. Chatzi and C. Chevrier and Chrousos, \{G. P.\} and E. Corpeleijn and O. Costa and N. Costet and S. Crozier and Graham Devereux and M. Doyon and M. Eggesb{\o} and Fantini, \{M. P.\} and S. Farchi and F. Forastiere and V. Georgiu and Godfrey, \{K. M.\} and D. Gori and V. Grote and W. Hanke and I. Hertz-Picciotto and B. Heude and Hivert, \{M. F.\} and D. Hryhorczuk and Huang, \{R. C.\} and H. Inskip and Karvonen, \{A. M.\} and Kenny, \{L. C.\} and B. Koletzko and K{\"u}pers, \{L. K.\} and H. Lagstr{\"o}m and I. Lehmann and P. Magnus and R. Majewska and J. M{\"a}kel{\"a} and Y. Manios and McAuliffe, \{F. M.\} and McDonald, \{S. W.\} and J. Mehegan and E. Mel{\'e}n and M. Mommers and Morgen, \{C. S.\} and G. Moschonis and D. Murray and \{N{\'i} Chaoimh\}, C. and Nohr, \{E. A.\} and \{Nybo Andersen\}, \{A. M.\} and E. Oken and Oostvogels, \{A. J.J.M.\} and A. Pac and E. Papadopoulou and J. Pekkanen and C. Pizzi and K. Polanska and D. Porta and L. Richiardi and Rifas-Shiman, \{S. L.\} and N. Roeleveld and L. Ronfani and Santos, \{A. C.\} and M. Standl and H. Stigum and C. Stoltenberg and E. Thiering and C. Thijs and M. Torrent and Tough, \{S. C.\} and T. Trnovec and S. Turner and \{van Gelder\}, \{M. M.H.J.\} and \{van Rossem\}, L. and \{von Berg\}, A. and M. Vrijheid and Vrijkotte, \{T. G.M.\} and J. West and Wijga, \{A. H.\} and J. Wright and O. Zvinchuk and S{\o}rensen, \{T. I.A.\} and Lawlor, \{D. A.\} and R. Gaillard and Jaddoe, \{V. W.V.\}",

year = "2019",

month = jul,

day = "1",

doi = "10.1111/1471-0528.15661",

language = "English",

volume = "126",

pages = "984--995",

journal = "BJOG: An International Journal of Obstetrics and Gynaecology",

issn = "1470-0328",

publisher = "John Wiley and Sons Inc",

number = "8",

}

Santos, S, Voerman, E, Amiano, P, Barros, H, Beilin, LJ, Bergström, A, Charles, MA, Chatzi, L, Chevrier, C, Chrousos, GP, Corpeleijn, E, Costa, O, Costet, N, Crozier, S, Devereux, G, Doyon, M, Eggesbø, M, Fantini, MP, Farchi, S, Forastiere, F, Georgiu, V, Godfrey, KM, Gori, D, Grote, V, Hanke, W, Hertz-Picciotto, I, Heude, B, Hivert, MF, Hryhorczuk, D, Huang, RC, Inskip, H, Karvonen, AM, Kenny, LC, Koletzko, B, Küpers, LK, Lagström, H, Lehmann, I, Magnus, P, Majewska, R, Mäkelä, J, Manios, Y, McAuliffe, FM, McDonald, SW, Mehegan, J, Melén, E, Mommers, M, Morgen, CS, Moschonis, G, Murray, D, Ní Chaoimh, C, Nohr, EA, Nybo Andersen, AM, Oken, E, Oostvogels, AJJM, Pac, A, Papadopoulou, E, Pekkanen, J, Pizzi, C, Polanska, K, Porta, D, Richiardi, L, Rifas-Shiman, SL, Roeleveld, N, Ronfani, L, Santos, AC, Standl, M, Stigum, H, Stoltenberg, C, Thiering, E, Thijs, C, Torrent, M, Tough, SC, Trnovec, T, Turner, S, van Gelder, MMHJ, van Rossem, L, von Berg, A, Vrijheid, M, Vrijkotte, TGM, West, J, Wijga, AH, Wright, J, Zvinchuk, O, Sørensen, TIA, Lawlor, DA, Gaillard, R & Jaddoe, VWV 2019, 'Impact of maternal body mass index and gestational weight gain on pregnancy complications: An individual participant data meta-analysis of European, North American and Australian cohorts.', BJOG: An International Journal of Obstetrics and Gynaecology, vol. 126, no. 8, pp. 984-995. https://doi.org/10.1111/1471-0528.15661

Impact of maternal body mass index and gestational weight gain on pregnancy complications: An individual participant data meta-analysis of European, North American and Australian cohorts. / Santos, S.; Voerman, E.; Amiano, P. et al.
In: BJOG: An International Journal of Obstetrics and Gynaecology, Vol. 126, No. 8, 01.07.2019, p. 984-995.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Impact of maternal body mass index and gestational weight gain on pregnancy complications: An individual participant data meta-analysis of European, North American and Australian cohorts.

AU - Santos, S.

AU - Voerman, E.

AU - Amiano, P.

AU - Barros, H.

AU - Beilin, L. J.

AU - Bergström, A.

AU - Charles, M. A.

AU - Chatzi, L.

AU - Chevrier, C.

AU - Chrousos, G. P.

AU - Corpeleijn, E.

AU - Costa, O.

AU - Costet, N.

AU - Crozier, S.

AU - Devereux, Graham

AU - Doyon, M.

AU - Eggesbø, M.

AU - Fantini, M. P.

AU - Farchi, S.

AU - Forastiere, F.

AU - Georgiu, V.

AU - Godfrey, K. M.

AU - Gori, D.

AU - Grote, V.

AU - Hanke, W.

AU - Hertz-Picciotto, I.

AU - Heude, B.

AU - Hivert, M. F.

AU - Hryhorczuk, D.

AU - Huang, R. C.

AU - Inskip, H.

AU - Karvonen, A. M.

AU - Kenny, L. C.

AU - Koletzko, B.

AU - Küpers, L. K.

AU - Lagström, H.

AU - Lehmann, I.

AU - Magnus, P.

AU - Majewska, R.

AU - Mäkelä, J.

AU - Manios, Y.

AU - McAuliffe, F. M.

AU - McDonald, S. W.

AU - Mehegan, J.

AU - Melén, E.

AU - Mommers, M.

AU - Morgen, C. S.

AU - Moschonis, G.

AU - Murray, D.

AU - Ní Chaoimh, C.

AU - Nohr, E. A.

AU - Nybo Andersen, A. M.

AU - Oken, E.

AU - Oostvogels, A. J.J.M.

AU - Pac, A.

AU - Papadopoulou, E.

AU - Pekkanen, J.

AU - Pizzi, C.

AU - Polanska, K.

AU - Porta, D.

AU - Richiardi, L.

AU - Rifas-Shiman, S. L.

AU - Roeleveld, N.

AU - Ronfani, L.

AU - Santos, A. C.

AU - Standl, M.

AU - Stigum, H.

AU - Stoltenberg, C.

AU - Thiering, E.

AU - Thijs, C.

AU - Torrent, M.

AU - Tough, S. C.

AU - Trnovec, T.

AU - Turner, S.

AU - van Gelder, M. M.H.J.

AU - van Rossem, L.

AU - von Berg, A.

AU - Vrijheid, M.

AU - Vrijkotte, T. G.M.

AU - West, J.

AU - Wijga, A. H.

AU - Wright, J.

AU - Zvinchuk, O.

AU - Sørensen, T. I.A.

AU - Lawlor, D. A.

AU - Gaillard, R.

AU - Jaddoe, V. W.V.

PY - 2019/7/1

Y1 - 2019/7/1

N2 - OBJECTIVETo assess the separate and combined associations of maternal pre-pregnancy BMI and gestational weight gain with the risks of pregnancy complications and their population impact.DESIGNIndividual participant data meta-analysis of 39 cohorts.SETTINGEurope, North America and Oceania.POPULATION265,270 births.METHODSInformation on maternal pre-pregnancy BMI, gestational weight gain, and pregnancy complications was obtained. Multilevel binary logistic regression models were used.MAIN OUTCOME MEASURESGestational hypertension, pre-eclampsia, gestational diabetes, preterm birth, small and large size for gestational age at birth.RESULTSHigher maternal pre-pregnancy BMI and gestational weight gain were, across their full ranges, associated with higher risks of gestational hypertensive disorders, gestational diabetes and large size for gestational age at birth. Preterm birth risk was higher at lower and higher BMI and weight gain. Compared to normal weight mothers with medium gestational weight gain, obese mothers with high gestational weight gain had the highest risk of any pregnancy complication (Odds Ratio 2.51 (95% Confidence Interval 2.31, 2.74)). We estimated that 23.9% of any pregnancy complication was attributable to maternal overweight/obesity and 31.6% of large size for gestational age infants was attributable to excessive gestational weight gain.CONCLUSIONSMaternal pre-pregnancy BMI and gestational weight gain are, across their full ranges, associated with the risks of pregnancy complications. Obese mothers with high gestational weight gain are at the highest risk of pregnancy complications. Promoting a healthy pre-pregnancy BMI and gestational weight gain may reduce the burden of pregnancy complications and ultimately the risk of maternal and neonatal morbidity. This article is protected by copyright. All rights reserved.

AB - OBJECTIVETo assess the separate and combined associations of maternal pre-pregnancy BMI and gestational weight gain with the risks of pregnancy complications and their population impact.DESIGNIndividual participant data meta-analysis of 39 cohorts.SETTINGEurope, North America and Oceania.POPULATION265,270 births.METHODSInformation on maternal pre-pregnancy BMI, gestational weight gain, and pregnancy complications was obtained. Multilevel binary logistic regression models were used.MAIN OUTCOME MEASURESGestational hypertension, pre-eclampsia, gestational diabetes, preterm birth, small and large size for gestational age at birth.RESULTSHigher maternal pre-pregnancy BMI and gestational weight gain were, across their full ranges, associated with higher risks of gestational hypertensive disorders, gestational diabetes and large size for gestational age at birth. Preterm birth risk was higher at lower and higher BMI and weight gain. Compared to normal weight mothers with medium gestational weight gain, obese mothers with high gestational weight gain had the highest risk of any pregnancy complication (Odds Ratio 2.51 (95% Confidence Interval 2.31, 2.74)). We estimated that 23.9% of any pregnancy complication was attributable to maternal overweight/obesity and 31.6% of large size for gestational age infants was attributable to excessive gestational weight gain.CONCLUSIONSMaternal pre-pregnancy BMI and gestational weight gain are, across their full ranges, associated with the risks of pregnancy complications. Obese mothers with high gestational weight gain are at the highest risk of pregnancy complications. Promoting a healthy pre-pregnancy BMI and gestational weight gain may reduce the burden of pregnancy complications and ultimately the risk of maternal and neonatal morbidity. This article is protected by copyright. All rights reserved.

KW - Birthweight

KW - body mass index

KW - pregnancy complications

KW - preterm birth

KW - weight gain

U2 - 10.1111/1471-0528.15661

DO - 10.1111/1471-0528.15661

M3 - Article

SN - 1470-0328

VL - 126

SP - 984

EP - 995

JO - BJOG: An International Journal of Obstetrics and Gynaecology

JF - BJOG: An International Journal of Obstetrics and Gynaecology

IS - 8

ER -

Santos S, Voerman E, Amiano P, Barros H, Beilin LJ, Bergström A et al. Impact of maternal body mass index and gestational weight gain on pregnancy complications: An individual participant data meta-analysis of European, North American and Australian cohorts. BJOG: An International Journal of Obstetrics and Gynaecology. 2019 Jul 1;126(8):984-995. Epub 2019 Feb 20. doi: 10.1111/1471-0528.15661

Impact of maternal body mass index and gestational weight gain on pregnancy complications: An individual participant data meta-analysis of European, North American and Australian cohorts.

Abstract

UN SDGs

Keywords

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