Impact of Malnutrition on Serum Levels of Pro‑inflammatory Cytokines among Plasmodium falciparum Malaria Subjects in Nigeria

Olusola Ajibaye; Victoria Olawunmi Adaramoye; Shittu Olalere; Agatha N. Ibekpobaoku; Mayowa A. Olasope; Gabriel O. Eniafe; Judith C. Okanazu; Bassey A. Orok; Sunday Ojo; Yetunde Adeeola Olukosi; Emmanuel Oluwadare Balogun

doi:10.4103/aam.aam_209_23

Impact of Malnutrition on Serum Levels of Pro‑inflammatory Cytokines among Plasmodium falciparum Malaria Subjects in Nigeria

Olusola Ajibaye
, Victoria Olawunmi Adaramoye
, Shittu Olalere
, Agatha N. Ibekpobaoku
, Mayowa A. Olasope
, Gabriel O. Eniafe
, Judith C. Okanazu
, Bassey A. Orok
, Sunday Ojo
, Yetunde Adeeola Olukosi
, Emmanuel Oluwadare Balogun

Nigerian Institute of Medical Research
Eko University of Medicine and Health Sciences
Department of Obstetrics and Gynaecology
Lagos University Teaching Hospital
University of Ilorin
University of Lagos
Lagos State University
Kwara State University
Ahmadu Bello University
The University of Tokyo

Research output: Contribution to journal › Article › peer-review

1 Citation (Scopus)

Abstract

Background: Understanding the impact of malnutrition on innate immune response in Plasmodium falciparum (Pf)‑infected subjects is critical for malaria control. Aims and Objectives: This study aims to investigate the nutritional status and innate immune response of Pf‑infected subjects in Lagos, Nigeria.

Materials and Methods: A total of 1183 patients with a history of fever or axillary temperature ≥37°C were screened microscopically for Pf at Ijede General Hospital, Lagos, Nigeria. Malnutrition was determined according to the U.S National Center for Health Statistics (NCHS) as stunting, wasting, or underweight when the Z‑score is <−2 in the participants aged <20 years. Serum levels of tumor necrosis factor‑alpha (TNF‑α), interleukin‑1β (IL‑1β), and IL‑12 were determined by capture ELISA while hematological parameters were measured using an automated hematology system.

Results: A total of 384 volunteers were positive for Pf, of which 114 were <20 years with a median age of 10 years. Overall malaria prevalence was 20.89%. The malnutrition rate was 89.5%; 24 (21.05%) were stunted, 30 (26.32%) were underweight, and 48 (42.11%) were wasted. Pro‑inflammatory cytokine responses were not affected by the type of malaria. TNF‑α was higher in participants <5 years (P = 0.001) and in malnourished patients (P < 0.05).

Conclusion: Together, it could be deduced that nutritional status influences Plasmodium falciparum malaria outcomes and progression pattern.

Original language	English
Pages (from-to)	379-384
Number of pages	6
Journal	Annals of African Medicine
Volume	23
Issue number	3
DOIs	https://doi.org/10.4103/aam.aam_209_23
Publication status	Published - 8 Jun 2024
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 2 Zero Hunger
SDG 3 Good Health and Well-being

Keywords

Cytokines
IL‑12
necrosis
plasmodium
TNF‑ α malnutrition

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10.4103/aam.aam_209_23

Cite this

Ajibaye, O., Adaramoye, V. O., Olalere, S., Ibekpobaoku, A. N., Olasope, M. A., Eniafe, G. O., Okanazu, J. C., Orok, B. A., Ojo, S., Olukosi, Y. A., & Balogun, E. O. (2024). Impact of Malnutrition on Serum Levels of Pro‑inflammatory Cytokines among Plasmodium falciparum Malaria Subjects in Nigeria. Annals of African Medicine, 23(3), 379-384. https://doi.org/10.4103/aam.aam_209_23

@article{41d36dc2c39f4427a37f6edaffac3bd0,

title = "Impact of Malnutrition on Serum Levels of Pro‑inflammatory Cytokines among Plasmodium falciparum Malaria Subjects in Nigeria",

abstract = "Background: Understanding the impact of malnutrition on innate immune response in Plasmodium falciparum (Pf)‑infected subjects is critical for malaria control. Aims and Objectives: This study aims to investigate the nutritional status and innate immune response of Pf‑infected subjects in Lagos, Nigeria. Materials and Methods: A total of 1183 patients with a history of fever or axillary temperature ≥37°C were screened microscopically for Pf at Ijede General Hospital, Lagos, Nigeria. Malnutrition was determined according to the U.S National Center for Health Statistics (NCHS) as stunting, wasting, or underweight when the Z‑score is <−2 in the participants aged <20 years. Serum levels of tumor necrosis factor‑alpha (TNF‑α), interleukin‑1β (IL‑1β), and IL‑12 were determined by capture ELISA while hematological parameters were measured using an automated hematology system. Results: A total of 384 volunteers were positive for Pf, of which 114 were <20 years with a median age of 10 years. Overall malaria prevalence was 20.89\%. The malnutrition rate was 89.5\%; 24 (21.05\%) were stunted, 30 (26.32\%) were underweight, and 48 (42.11\%) were wasted. Pro‑inflammatory cytokine responses were not affected by the type of malaria. TNF‑α was higher in participants <5 years (P = 0.001) and in malnourished patients (P < 0.05). Conclusion: Together, it could be deduced that nutritional status influences Plasmodium falciparum malaria outcomes and progression pattern.",

keywords = "Cytokines, IL‑12, necrosis, plasmodium, TNF‑ α malnutrition",

author = "Olusola Ajibaye and Adaramoye, \{Victoria Olawunmi\} and Shittu Olalere and Ibekpobaoku, \{Agatha N.\} and Olasope, \{Mayowa A.\} and Eniafe, \{Gabriel O.\} and Okanazu, \{Judith C.\} and Orok, \{Bassey A.\} and Sunday Ojo and Olukosi, \{Yetunde Adeeola\} and Balogun, \{Emmanuel Oluwadare\}",

year = "2024",

month = jun,

day = "8",

doi = "10.4103/aam.aam\_209\_23",

language = "English",

volume = "23",

pages = "379--384",

journal = "Annals of African Medicine",

issn = "1596-3519",

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number = "3",

}

TY - JOUR

T1 - Impact of Malnutrition on Serum Levels of Pro‑inflammatory Cytokines among Plasmodium falciparum Malaria Subjects in Nigeria

AU - Ajibaye, Olusola

AU - Adaramoye, Victoria Olawunmi

AU - Olalere, Shittu

AU - Ibekpobaoku, Agatha N.

AU - Olasope, Mayowa A.

AU - Eniafe, Gabriel O.

AU - Okanazu, Judith C.

AU - Orok, Bassey A.

AU - Ojo, Sunday

AU - Olukosi, Yetunde Adeeola

AU - Balogun, Emmanuel Oluwadare

PY - 2024/6/8

Y1 - 2024/6/8

N2 - Background: Understanding the impact of malnutrition on innate immune response in Plasmodium falciparum (Pf)‑infected subjects is critical for malaria control. Aims and Objectives: This study aims to investigate the nutritional status and innate immune response of Pf‑infected subjects in Lagos, Nigeria. Materials and Methods: A total of 1183 patients with a history of fever or axillary temperature ≥37°C were screened microscopically for Pf at Ijede General Hospital, Lagos, Nigeria. Malnutrition was determined according to the U.S National Center for Health Statistics (NCHS) as stunting, wasting, or underweight when the Z‑score is <−2 in the participants aged <20 years. Serum levels of tumor necrosis factor‑alpha (TNF‑α), interleukin‑1β (IL‑1β), and IL‑12 were determined by capture ELISA while hematological parameters were measured using an automated hematology system. Results: A total of 384 volunteers were positive for Pf, of which 114 were <20 years with a median age of 10 years. Overall malaria prevalence was 20.89%. The malnutrition rate was 89.5%; 24 (21.05%) were stunted, 30 (26.32%) were underweight, and 48 (42.11%) were wasted. Pro‑inflammatory cytokine responses were not affected by the type of malaria. TNF‑α was higher in participants <5 years (P = 0.001) and in malnourished patients (P < 0.05). Conclusion: Together, it could be deduced that nutritional status influences Plasmodium falciparum malaria outcomes and progression pattern.

AB - Background: Understanding the impact of malnutrition on innate immune response in Plasmodium falciparum (Pf)‑infected subjects is critical for malaria control. Aims and Objectives: This study aims to investigate the nutritional status and innate immune response of Pf‑infected subjects in Lagos, Nigeria. Materials and Methods: A total of 1183 patients with a history of fever or axillary temperature ≥37°C were screened microscopically for Pf at Ijede General Hospital, Lagos, Nigeria. Malnutrition was determined according to the U.S National Center for Health Statistics (NCHS) as stunting, wasting, or underweight when the Z‑score is <−2 in the participants aged <20 years. Serum levels of tumor necrosis factor‑alpha (TNF‑α), interleukin‑1β (IL‑1β), and IL‑12 were determined by capture ELISA while hematological parameters were measured using an automated hematology system. Results: A total of 384 volunteers were positive for Pf, of which 114 were <20 years with a median age of 10 years. Overall malaria prevalence was 20.89%. The malnutrition rate was 89.5%; 24 (21.05%) were stunted, 30 (26.32%) were underweight, and 48 (42.11%) were wasted. Pro‑inflammatory cytokine responses were not affected by the type of malaria. TNF‑α was higher in participants <5 years (P = 0.001) and in malnourished patients (P < 0.05). Conclusion: Together, it could be deduced that nutritional status influences Plasmodium falciparum malaria outcomes and progression pattern.

KW - Cytokines

KW - IL‑12

KW - necrosis

KW - plasmodium

KW - TNF‑ α malnutrition

U2 - 10.4103/aam.aam_209_23

DO - 10.4103/aam.aam_209_23

M3 - Article

C2 - 39034562

AN - SCOPUS:85199256362

SN - 1596-3519

VL - 23

SP - 379

EP - 384

JO - Annals of African Medicine

JF - Annals of African Medicine

IS - 3

ER -

Impact of Malnutrition on Serum Levels of Pro‑inflammatory Cytokines among Plasmodium falciparum Malaria Subjects in Nigeria

Abstract

UN SDGs

Keywords

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