Impact of a T cell-based blood test for tuberculosis infection on clinical decision-making in routine practice

Sarah Gooding; Oni Chowdhury; Tim Hinks; Luca Richeldi; Monica Losi; Katie Ewer; Kerry Millington; Ruba Gunatheesan; Stefania Cerri; Jeremy McNally; Ajit Lalvani

doi:10.1016/j.jinf.2006.11.002

Impact of a T cell-based blood test for tuberculosis infection on clinical decision-making in routine practice

Sarah Gooding, Oni Chowdhury, Tim Hinks, Luca Richeldi, Monica Losi, Katie Ewer, Kerry Millington, Ruba Gunatheesan, Stefania Cerri, Jeremy McNally, Ajit Lalvani

Research output: Contribution to journal › Article › peer-review

22 Citations (Scopus)

Abstract

New T cell-based blood tests for tuberculosis infection could improve diagnosis of tuberculosis but their clinical utility remains unknown. We describe the role of the ELISpot test in the diagnostic work-up of 13 patients presenting with suspected tuberculosis in routine practice. Of the seven patients with a final diagnosis of active tuberculosis, all were positive by ELISpot including three with false-negative tuberculin skin test results. Rapid determination of tuberculosis infection by ELISpot accelerated the diagnosis of tuberculosis, enabling early treatment initiation.

Original language	English
Pages (from-to)	e169-e174
Journal	Journal of Infection
Volume	54
Issue number	3
DOIs	https://doi.org/10.1016/j.jinf.2006.11.002
Publication status	Published - 1 Mar 2007
Externally published	Yes

Keywords

Blood test
Diagnosis
Skin test
Tuberculosis

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.jinf.2006.11.002Licence: CC BY

Cite this

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title = "Impact of a T cell-based blood test for tuberculosis infection on clinical decision-making in routine practice",

abstract = "New T cell-based blood tests for tuberculosis infection could improve diagnosis of tuberculosis but their clinical utility remains unknown. We describe the role of the ELISpot test in the diagnostic work-up of 13 patients presenting with suspected tuberculosis in routine practice. Of the seven patients with a final diagnosis of active tuberculosis, all were positive by ELISpot including three with false-negative tuberculin skin test results. Rapid determination of tuberculosis infection by ELISpot accelerated the diagnosis of tuberculosis, enabling early treatment initiation.",

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AU - Gooding, Sarah

AU - Chowdhury, Oni

AU - Hinks, Tim

AU - Richeldi, Luca

AU - Losi, Monica

AU - Ewer, Katie

AU - Millington, Kerry

AU - Gunatheesan, Ruba

AU - Cerri, Stefania

AU - McNally, Jeremy

AU - Lalvani, Ajit

PY - 2007/3/1

Y1 - 2007/3/1

N2 - New T cell-based blood tests for tuberculosis infection could improve diagnosis of tuberculosis but their clinical utility remains unknown. We describe the role of the ELISpot test in the diagnostic work-up of 13 patients presenting with suspected tuberculosis in routine practice. Of the seven patients with a final diagnosis of active tuberculosis, all were positive by ELISpot including three with false-negative tuberculin skin test results. Rapid determination of tuberculosis infection by ELISpot accelerated the diagnosis of tuberculosis, enabling early treatment initiation.

AB - New T cell-based blood tests for tuberculosis infection could improve diagnosis of tuberculosis but their clinical utility remains unknown. We describe the role of the ELISpot test in the diagnostic work-up of 13 patients presenting with suspected tuberculosis in routine practice. Of the seven patients with a final diagnosis of active tuberculosis, all were positive by ELISpot including three with false-negative tuberculin skin test results. Rapid determination of tuberculosis infection by ELISpot accelerated the diagnosis of tuberculosis, enabling early treatment initiation.

KW - Blood test

KW - Diagnosis

KW - Skin test

KW - Tuberculosis

U2 - 10.1016/j.jinf.2006.11.002

DO - 10.1016/j.jinf.2006.11.002

M3 - Article

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SP - e169-e174

JO - Journal of Infection

JF - Journal of Infection

IS - 3

ER -

Impact of a T cell-based blood test for tuberculosis infection on clinical decision-making in routine practice

Abstract

Keywords

UN SDGs

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