Immunosuppression in Gambian trypanosomiasis

B. M. Greenwood; H. C. Whittle; David Molyneux

doi:10.1016/0035-9203(73)90013-8

Immunosuppression in Gambian trypanosomiasis

B. M. Greenwood, H. C. Whittle, David Molyneux

Ahmadu Bello University

Research output: Contribution to journal › Article › peer-review

70 Citations (Scopus)

Abstract

Cellular and humoral immune responses were studied in 38 patients with Gambian trypanosomiasis and compared with those of 43 matched controls. Expression of cell mediated immunity, induction of cell mediated immunity and expression of humoral immunity were all impaired in the patients with trypanosomiasis. It is suggested that immunosuppression induced by T. gambiense may contribute to the increased susceptibility to secondary infection observed in patients with African trypanosomiasis.

Original language	English
Pages (from-to)	846-850
Number of pages	5
Journal	Transactions of the Royal Society of Tropical Medicine and Hygiene
Volume	67
Issue number	6
DOIs	https://doi.org/10.1016/0035-9203(73)90013-8
Publication status	Published - 1 Jan 1973
Externally published	Yes

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title = "Immunosuppression in Gambian trypanosomiasis",

abstract = "Cellular and humoral immune responses were studied in 38 patients with Gambian trypanosomiasis and compared with those of 43 matched controls. Expression of cell mediated immunity, induction of cell mediated immunity and expression of humoral immunity were all impaired in the patients with trypanosomiasis. It is suggested that immunosuppression induced by T. gambiense may contribute to the increased susceptibility to secondary infection observed in patients with African trypanosomiasis.",

author = "Greenwood, \{B. M.\} and Whittle, \{H. C.\} and David Molyneux",

year = "1973",

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AU - Greenwood, B. M.

AU - Whittle, H. C.

AU - Molyneux, David

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Y1 - 1973/1/1

N2 - Cellular and humoral immune responses were studied in 38 patients with Gambian trypanosomiasis and compared with those of 43 matched controls. Expression of cell mediated immunity, induction of cell mediated immunity and expression of humoral immunity were all impaired in the patients with trypanosomiasis. It is suggested that immunosuppression induced by T. gambiense may contribute to the increased susceptibility to secondary infection observed in patients with African trypanosomiasis.

AB - Cellular and humoral immune responses were studied in 38 patients with Gambian trypanosomiasis and compared with those of 43 matched controls. Expression of cell mediated immunity, induction of cell mediated immunity and expression of humoral immunity were all impaired in the patients with trypanosomiasis. It is suggested that immunosuppression induced by T. gambiense may contribute to the increased susceptibility to secondary infection observed in patients with African trypanosomiasis.

U2 - 10.1016/0035-9203(73)90013-8

DO - 10.1016/0035-9203(73)90013-8

M3 - Article

SN - 0035-9203

VL - 67

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EP - 850

JO - Transactions of the Royal Society of Tropical Medicine and Hygiene

JF - Transactions of the Royal Society of Tropical Medicine and Hygiene

IS - 6

ER -

Immunosuppression in Gambian trypanosomiasis

Abstract

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