Immunity to Onchocerca spp. in animal hosts

D. Abraham; R. Lucius; Alexander J. Trees

doi:10.1016/s1471-4922(02)02245-6

Immunity to Onchocerca spp. in animal hosts

D. Abraham, R. Lucius, Alexander J. Trees

Tropical Disease Biology

Research output: Contribution to journal › Review article › peer-review

40 Citations (Scopus)

Abstract

This review summarizes research using Onchocerca spp. in chimpanzees, cattle and mice to gain insight into the protective immune response to the filarial worm Onchocerca, volvulus in humans. In addition, Acanthocheilonema viteae has been evaluated as a surrogate filarial worm for studying immunity to the infection. Immune mechanisms controlling these infections are described and initial success using recombinant antigen vaccines in these models is reviewed.

Original language	English
Pages (from-to)	164-171
Number of pages	8
Journal	Trends In Parasitology
Volume	18
Issue number	4
DOIs	https://doi.org/10.1016/s1471-4922(02)02245-6
Publication status	Published - 1 Apr 2002

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10.1016/s1471-4922(02)02245-6

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title = "Immunity to Onchocerca spp. in animal hosts",

abstract = "This review summarizes research using Onchocerca spp. in chimpanzees, cattle and mice to gain insight into the protective immune response to the filarial worm Onchocerca, volvulus in humans. In addition, Acanthocheilonema viteae has been evaluated as a surrogate filarial worm for studying immunity to the infection. Immune mechanisms controlling these infections are described and initial success using recombinant antigen vaccines in these models is reviewed.",

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AU - Abraham, D.

AU - Lucius, R.

AU - Trees, Alexander J.

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N2 - This review summarizes research using Onchocerca spp. in chimpanzees, cattle and mice to gain insight into the protective immune response to the filarial worm Onchocerca, volvulus in humans. In addition, Acanthocheilonema viteae has been evaluated as a surrogate filarial worm for studying immunity to the infection. Immune mechanisms controlling these infections are described and initial success using recombinant antigen vaccines in these models is reviewed.

AB - This review summarizes research using Onchocerca spp. in chimpanzees, cattle and mice to gain insight into the protective immune response to the filarial worm Onchocerca, volvulus in humans. In addition, Acanthocheilonema viteae has been evaluated as a surrogate filarial worm for studying immunity to the infection. Immune mechanisms controlling these infections are described and initial success using recombinant antigen vaccines in these models is reviewed.

U2 - 10.1016/s1471-4922(02)02245-6

DO - 10.1016/s1471-4922(02)02245-6

M3 - Review article

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VL - 18

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EP - 171

JO - Trends In Parasitology

JF - Trends In Parasitology

IS - 4

ER -

Immunity to Onchocerca spp. in animal hosts

Abstract

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