Identification of a 1,2,4,5-tetraoxane antimalarial drug-development candidate (RKA 182) with superior properties to the semisynthetic artemisinins.

Paul M. O'Neill; Richard K. Amewu; Gemma L. Nixon; Fatima Bousejra ElGarah; Mathirut Mungthin; James Chadwick; Alison E. Shone; Livia Vivas; Hollie Lander; Victoria Barton; Sant Muangnoicharoen; Patrick G. Bray; Jill Davies; B. Kevin Park; Sergio Wittlin; Reto Brun; Michael Preschel; Kesheng Zhang; Steve Ward

doi:10.1002/anie.201001026

Identification of a 1,2,4,5-tetraoxane antimalarial drug-development candidate (RKA 182) with superior properties to the semisynthetic artemisinins.

Paul M. O'Neill
, Richard K. Amewu
, Gemma L. Nixon
, Fatima Bousejra ElGarah
, Mathirut Mungthin
, James Chadwick
, Alison E. Shone
, Livia Vivas
, Hollie Lander
, Victoria Barton
, Sant Muangnoicharoen
, Patrick G. Bray
, Jill Davies
, B. Kevin Park
, Sergio Wittlin
, Reto Brun
, Michael Preschel
, Kesheng Zhang
, Steve Ward

Tropical Disease Biology

Research output: Contribution to journal › Article › peer-review

120 Citations (Scopus)

Original language	English
Pages (from-to)	5693-5697
Number of pages	5
Journal	Angewandte Chemie - International Edition
Volume	49
Issue number	33
DOIs	https://doi.org/10.1002/anie.201001026
Publication status	Published - 13 Jul 2010

Keywords

Antimalarial agents
Drug development
Endoperoxides
Medicinal chemistry
Tetraoxanes

Access to Document

10.1002/anie.201001026

Cite this

O'Neill, P. M., Amewu, R. K., Nixon, G. L., ElGarah, F. B., Mungthin, M., Chadwick, J., Shone, A. E., Vivas, L., Lander, H., Barton, V., Muangnoicharoen, S., Bray, P. G., Davies, J., Park, B. K., Wittlin, S., Brun, R., Preschel, M., Zhang, K., & Ward, S. (2010). Identification of a 1,2,4,5-tetraoxane antimalarial drug-development candidate (RKA 182) with superior properties to the semisynthetic artemisinins. Angewandte Chemie - International Edition, 49(33), 5693-5697. https://doi.org/10.1002/anie.201001026

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title = "Identification of a 1,2,4,5-tetraoxane antimalarial drug-development candidate (RKA 182) with superior properties to the semisynthetic artemisinins.",

keywords = "Antimalarial agents, Drug development, Endoperoxides, Medicinal chemistry, Tetraoxanes",

author = "O'Neill, \{Paul M.\} and Amewu, \{Richard K.\} and Nixon, \{Gemma L.\} and ElGarah, \{Fatima Bousejra\} and Mathirut Mungthin and James Chadwick and Shone, \{Alison E.\} and Livia Vivas and Hollie Lander and Victoria Barton and Sant Muangnoicharoen and Bray, \{Patrick G.\} and Jill Davies and Park, \{B. Kevin\} and Sergio Wittlin and Reto Brun and Michael Preschel and Kesheng Zhang and Steve Ward",

year = "2010",

month = jul,

day = "13",

doi = "10.1002/anie.201001026",

language = "English",

volume = "49",

pages = "5693--5697",

journal = "Angewandte Chemie - International Edition",

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}

O'Neill, PM, Amewu, RK, Nixon, GL, ElGarah, FB, Mungthin, M, Chadwick, J, Shone, AE, Vivas, L, Lander, H, Barton, V, Muangnoicharoen, S, Bray, PG, Davies, J, Park, BK, Wittlin, S, Brun, R, Preschel, M, Zhang, K & Ward, S 2010, 'Identification of a 1,2,4,5-tetraoxane antimalarial drug-development candidate (RKA 182) with superior properties to the semisynthetic artemisinins.', Angewandte Chemie - International Edition, vol. 49, no. 33, pp. 5693-5697. https://doi.org/10.1002/anie.201001026

TY - JOUR

T1 - Identification of a 1,2,4,5-tetraoxane antimalarial drug-development candidate (RKA 182) with superior properties to the semisynthetic artemisinins.

AU - O'Neill, Paul M.

AU - Amewu, Richard K.

AU - Nixon, Gemma L.

AU - ElGarah, Fatima Bousejra

AU - Mungthin, Mathirut

AU - Chadwick, James

AU - Shone, Alison E.

AU - Vivas, Livia

AU - Lander, Hollie

AU - Barton, Victoria

AU - Muangnoicharoen, Sant

AU - Bray, Patrick G.

AU - Davies, Jill

AU - Park, B. Kevin

AU - Wittlin, Sergio

AU - Brun, Reto

AU - Preschel, Michael

AU - Zhang, Kesheng

AU - Ward, Steve

PY - 2010/7/13

Y1 - 2010/7/13

KW - Antimalarial agents

KW - Drug development

KW - Endoperoxides

KW - Medicinal chemistry

KW - Tetraoxanes

U2 - 10.1002/anie.201001026

DO - 10.1002/anie.201001026

M3 - Article

SN - 1433-7851

VL - 49

SP - 5693

EP - 5697

JO - Angewandte Chemie - International Edition

JF - Angewandte Chemie - International Edition

IS - 33

ER -