Identification and quantification of diethylcarbamazine and diethylcarbamazine n-oxide in rat urine

G. Edwards; Steve Ward; A. M. Breckenridge; M. L.E. Orme

doi:10.3109/00498258109045303

Identification and quantification of diethylcarbamazine and diethylcarbamazine n-oxide in rat urine

G. Edwards, Steve Ward, A. M. Breckenridge, M. L.E. Orme

University of Liverpool

Research output: Contribution to journal › Article › peer-review

9 Citations (Scopus)

Abstract

1. Diethylcarbamazine and its major metabolite, diethylcarbamazine N-oxide have been identified and quantified in the urine of rats dosed orally with [14C]diethylcarbamazine citrate. 2. The urinary excretion of diethylcarbamazine N-oxide as percentage of dose was not dose-dependent. 3. These observations are in agreement with previous studies. As the metabolism of diethylcarbamazine in the rat differs greatly from man, the rat is unsuitable as an animal model in studies of diethylcarbamazine disposition.

Original language	English
Pages (from-to)	281-284
Number of pages	4
Journal	Xenobiotica
Volume	11
Issue number	4
DOIs	https://doi.org/10.3109/00498258109045303
Publication status	Published - 1 Jan 1981
Externally published	Yes

Access to Document

10.3109/00498258109045303

Cite this

@article{0484f6f27fbd44c280f75d7de8edab36,

title = "Identification and quantification of diethylcarbamazine and diethylcarbamazine n-oxide in rat urine",

abstract = "1. Diethylcarbamazine and its major metabolite, diethylcarbamazine N-oxide have been identified and quantified in the urine of rats dosed orally with [14C]diethylcarbamazine citrate. 2. The urinary excretion of diethylcarbamazine N-oxide as percentage of dose was not dose-dependent. 3. These observations are in agreement with previous studies. As the metabolism of diethylcarbamazine in the rat differs greatly from man, the rat is unsuitable as an animal model in studies of diethylcarbamazine disposition.",

author = "G. Edwards and Steve Ward and Breckenridge, \{A. M.\} and Orme, \{M. L.E.\}",

year = "1981",

month = jan,

day = "1",

doi = "10.3109/00498258109045303",

language = "English",

volume = "11",

pages = "281--284",

journal = "Xenobiotica",

issn = "0049-8254",

publisher = "Taylor and Francis Ltd.",

number = "4",

}

TY - JOUR

T1 - Identification and quantification of diethylcarbamazine and diethylcarbamazine n-oxide in rat urine

AU - Edwards, G.

AU - Ward, Steve

AU - Breckenridge, A. M.

AU - Orme, M. L.E.

PY - 1981/1/1

Y1 - 1981/1/1

N2 - 1. Diethylcarbamazine and its major metabolite, diethylcarbamazine N-oxide have been identified and quantified in the urine of rats dosed orally with [14C]diethylcarbamazine citrate. 2. The urinary excretion of diethylcarbamazine N-oxide as percentage of dose was not dose-dependent. 3. These observations are in agreement with previous studies. As the metabolism of diethylcarbamazine in the rat differs greatly from man, the rat is unsuitable as an animal model in studies of diethylcarbamazine disposition.

AB - 1. Diethylcarbamazine and its major metabolite, diethylcarbamazine N-oxide have been identified and quantified in the urine of rats dosed orally with [14C]diethylcarbamazine citrate. 2. The urinary excretion of diethylcarbamazine N-oxide as percentage of dose was not dose-dependent. 3. These observations are in agreement with previous studies. As the metabolism of diethylcarbamazine in the rat differs greatly from man, the rat is unsuitable as an animal model in studies of diethylcarbamazine disposition.

U2 - 10.3109/00498258109045303

DO - 10.3109/00498258109045303

M3 - Article

SN - 0049-8254

VL - 11

SP - 281

EP - 284

JO - Xenobiotica

JF - Xenobiotica

IS - 4

ER -

Identification and quantification of diethylcarbamazine and diethylcarbamazine n-oxide in rat urine

Abstract

Access to Document

Fingerprint

Cite this