Identification and Detection of a Novel Point Mutation in the Chitin Synthase Gene of Culex Pipiens Associated With Diflubenzuron Resistance

Emmanouil A. Fotakis; Valentina Mastrantonio; Linta Grigoraki; Daniele Porretta; Arianna Puggioli; Alexandra Chaskopoulou; Hugo Osório; Mylène Weill; Romeo Bellini; Sandra Urbanelli; John Vontas

doi:10.1371/journal.pntd.0008284

Identification and Detection of a Novel Point Mutation in the Chitin Synthase Gene of Culex Pipiens Associated With Diflubenzuron Resistance

Emmanouil A. Fotakis
, Valentina Mastrantonio
, Linta Grigoraki
, Daniele Porretta
, Arianna Puggioli
, Alexandra Chaskopoulou
, Hugo Osório
, Mylène Weill
, Romeo Bellini
, Sandra Urbanelli
, John Vontas

Vector Biology

Agricultural University of Athens
Foundation for Research and Technology-Hellas
University of Rome La Sapienza
Centro Agricoltura Ambiente
United States Department of Agriculture
Instituto Nacional de Saúde Doutor Ricardo Jorge
Université de Montpellier

Research output: Contribution to journal › Article › peer-review

30 Citations (Scopus)

Abstract

Diflubenzuron (DFB) is one of the most used insecticides in mosquito larval control including that of Culex pipiens, the proven vector of the recent West Nile Virus epidemics in Europe. Two mutations (I1043L and I1043M) in the chitin synthase (CHS) putative binding site of DFB have been previously reported in Cx. pipiens from Italy and associated with high levels of resistance against this larvicide.

Original language	English
Article number	e0008284
Pages (from-to)	1-10
Number of pages	10
Journal	PLoS Neglected Tropical Diseases
Volume	14
Issue number	5
DOIs	https://doi.org/10.1371/journal.pntd.0008284
Publication status	Published - 1 May 2020

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

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10.1371/journal.pntd.0008284Licence: CC BY

JournalAccepted author manuscript, 4.23 MBLicence: CC BY

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Fotakis, E. A., Mastrantonio, V., Grigoraki, L., Porretta, D., Puggioli, A., Chaskopoulou, A., Osório, H., Weill, M., Bellini, R., Urbanelli, S., & Vontas, J. (2020). Identification and Detection of a Novel Point Mutation in the Chitin Synthase Gene of Culex Pipiens Associated With Diflubenzuron Resistance. PLoS Neglected Tropical Diseases, 14(5), 1-10. Article e0008284. https://doi.org/10.1371/journal.pntd.0008284

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Fotakis, EA, Mastrantonio, V, Grigoraki, L, Porretta, D, Puggioli, A, Chaskopoulou, A, Osório, H, Weill, M, Bellini, R, Urbanelli, S & Vontas, J 2020, 'Identification and Detection of a Novel Point Mutation in the Chitin Synthase Gene of Culex Pipiens Associated With Diflubenzuron Resistance', PLoS Neglected Tropical Diseases, vol. 14, no. 5, e0008284, pp. 1-10. https://doi.org/10.1371/journal.pntd.0008284

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T1 - Identification and Detection of a Novel Point Mutation in the Chitin Synthase Gene of Culex Pipiens Associated With Diflubenzuron Resistance

AU - Fotakis, Emmanouil A.

AU - Mastrantonio, Valentina

AU - Grigoraki, Linta

AU - Porretta, Daniele

AU - Puggioli, Arianna

AU - Chaskopoulou, Alexandra

AU - Osório, Hugo

AU - Weill, Mylène

AU - Bellini, Romeo

AU - Urbanelli, Sandra

AU - Vontas, John

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AB - Diflubenzuron (DFB) is one of the most used insecticides in mosquito larval control including that of Culex pipiens, the proven vector of the recent West Nile Virus epidemics in Europe. Two mutations (I1043L and I1043M) in the chitin synthase (CHS) putative binding site of DFB have been previously reported in Cx. pipiens from Italy and associated with high levels of resistance against this larvicide.

U2 - 10.1371/journal.pntd.0008284

DO - 10.1371/journal.pntd.0008284

M3 - Article

SN - 1935-2727

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JO - PLoS Neglected Tropical Diseases

JF - PLoS Neglected Tropical Diseases

IS - 5

M1 - e0008284

ER -

Identification and Detection of a Novel Point Mutation in the Chitin Synthase Gene of Culex Pipiens Associated With Diflubenzuron Resistance

Abstract

UN SDGs

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