Identification and Detection of a Novel Point Mutation in the Chitin Synthase Gene of Culex Pipiens Associated With Diflubenzuron Resistance

Emmanouil A. Fotakis; Valentina Mastrantonio; Linta Grigoraki; Daniele Porretta; Arianna Puggioli; Alexandra Chaskopoulou; Hugo Osório; Mylène Weill; Romeo Bellini; Sandra Urbanelli; John Vontas

doi:10.1371/journal.pntd.0008284

Identification and Detection of a Novel Point Mutation in the Chitin Synthase Gene of Culex Pipiens Associated With Diflubenzuron Resistance

Emmanouil A. Fotakis, Valentina Mastrantonio, Linta Grigoraki, Daniele Porretta, Arianna Puggioli, Alexandra Chaskopoulou, Hugo Osório, Mylène Weill, Romeo Bellini, Sandra Urbanelli, John Vontas

Vector Biology

Research output: Contribution to journal › Article › peer-review

27 Citations (Scopus)

Abstract

Diflubenzuron (DFB) is one of the most used insecticides in mosquito larval control including that of Culex pipiens, the proven vector of the recent West Nile Virus epidemics in Europe. Two mutations (I1043L and I1043M) in the chitin synthase (CHS) putative binding site of DFB have been previously reported in Cx. pipiens from Italy and associated with high levels of resistance against this larvicide.

Original language	English
Article number	e0008284
Pages (from-to)	1-10
Number of pages	10
Journal	PLoS Neglected Tropical Diseases
Volume	14
Issue number	5
DOIs	https://doi.org/10.1371/journal.pntd.0008284
Publication status	Published - 1 May 2020

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Fotakis, E. A., Mastrantonio, V., Grigoraki, L., Porretta, D., Puggioli, A., Chaskopoulou, A., Osório, H., Weill, M., Bellini, R., Urbanelli, S., & Vontas, J. (2020). Identification and Detection of a Novel Point Mutation in the Chitin Synthase Gene of Culex Pipiens Associated With Diflubenzuron Resistance. PLoS Neglected Tropical Diseases, 14(5), 1-10. Article e0008284. https://doi.org/10.1371/journal.pntd.0008284

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Fotakis, EA, Mastrantonio, V, Grigoraki, L, Porretta, D, Puggioli, A, Chaskopoulou, A, Osório, H, Weill, M, Bellini, R, Urbanelli, S & Vontas, J 2020, 'Identification and Detection of a Novel Point Mutation in the Chitin Synthase Gene of Culex Pipiens Associated With Diflubenzuron Resistance', PLoS Neglected Tropical Diseases, vol. 14, no. 5, e0008284, pp. 1-10. https://doi.org/10.1371/journal.pntd.0008284

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AU - Fotakis, Emmanouil A.

AU - Mastrantonio, Valentina

AU - Grigoraki, Linta

AU - Porretta, Daniele

AU - Puggioli, Arianna

AU - Chaskopoulou, Alexandra

AU - Osório, Hugo

AU - Weill, Mylène

AU - Bellini, Romeo

AU - Urbanelli, Sandra

AU - Vontas, John

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AB - Diflubenzuron (DFB) is one of the most used insecticides in mosquito larval control including that of Culex pipiens, the proven vector of the recent West Nile Virus epidemics in Europe. Two mutations (I1043L and I1043M) in the chitin synthase (CHS) putative binding site of DFB have been previously reported in Cx. pipiens from Italy and associated with high levels of resistance against this larvicide.

U2 - 10.1371/journal.pntd.0008284

DO - 10.1371/journal.pntd.0008284

M3 - Article

SN - 1935-2727

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IS - 5

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ER -

Identification and Detection of a Novel Point Mutation in the Chitin Synthase Gene of Culex Pipiens Associated With Diflubenzuron Resistance

Abstract

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