Human leucocyte antigen (HLA) and malaria morbidity in a Gambian community

S. Bennett; S. J. Allen; O. Olerup; D. J. Jackson; J. G. Wheeler; P. A. Rowe; E. M. Riley; B. M. Greenwood

doi:10.1016/0035-9203(93)90130-I

Human leucocyte antigen (HLA) and malaria morbidity in a Gambian community

S. Bennett
, S. J. Allen
, O. Olerup
, D. J. Jackson
, J. G. Wheeler
, P. A. Rowe
, E. M. Riley
, B. M. Greenwood

Research output: Contribution to journal › Article › peer-review

23 Citations (Scopus)

Abstract

Human leucocyte antigen (HLA) class I and class II typing was performed on 177 children in a rural area of The Gambia who were followed for 2 years in a longitudinal study of malaria morbidity. A comparison was made between those who experienced an episode of clinical malaria in one or both years and those who showed no evidence of infection in either year. No convincing association was found between morbidity and class I phenotype. An overall association of morbidity with the distribution of class II haplotypes was seen, but associations with individual DR-DQ haplotypes were not conclusive.

Original language	English
Pages (from-to)	286-287
Number of pages	2
Journal	Transactions of the Royal Society of Tropical Medicine and Hygiene
Volume	87
Issue number	3
DOIs	https://doi.org/10.1016/0035-9203(93)90130-I
Publication status	Published - 1 Jun 1993
Externally published	Yes

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title = "Human leucocyte antigen (HLA) and malaria morbidity in a Gambian community",

abstract = "Human leucocyte antigen (HLA) class I and class II typing was performed on 177 children in a rural area of The Gambia who were followed for 2 years in a longitudinal study of malaria morbidity. A comparison was made between those who experienced an episode of clinical malaria in one or both years and those who showed no evidence of infection in either year. No convincing association was found between morbidity and class I phenotype. An overall association of morbidity with the distribution of class II haplotypes was seen, but associations with individual DR-DQ haplotypes were not conclusive.",

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doi = "10.1016/0035-9203(93)90130-I",

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AU - Bennett, S.

AU - Allen, S. J.

AU - Olerup, O.

AU - Jackson, D. J.

AU - Wheeler, J. G.

AU - Rowe, P. A.

AU - Riley, E. M.

AU - Greenwood, B. M.

PY - 1993/6/1

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N2 - Human leucocyte antigen (HLA) class I and class II typing was performed on 177 children in a rural area of The Gambia who were followed for 2 years in a longitudinal study of malaria morbidity. A comparison was made between those who experienced an episode of clinical malaria in one or both years and those who showed no evidence of infection in either year. No convincing association was found between morbidity and class I phenotype. An overall association of morbidity with the distribution of class II haplotypes was seen, but associations with individual DR-DQ haplotypes were not conclusive.

AB - Human leucocyte antigen (HLA) class I and class II typing was performed on 177 children in a rural area of The Gambia who were followed for 2 years in a longitudinal study of malaria morbidity. A comparison was made between those who experienced an episode of clinical malaria in one or both years and those who showed no evidence of infection in either year. No convincing association was found between morbidity and class I phenotype. An overall association of morbidity with the distribution of class II haplotypes was seen, but associations with individual DR-DQ haplotypes were not conclusive.

U2 - 10.1016/0035-9203(93)90130-I

DO - 10.1016/0035-9203(93)90130-I

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JF - Transactions of the Royal Society of Tropical Medicine and Hygiene

IS - 3

ER -

Human leucocyte antigen (HLA) and malaria morbidity in a Gambian community

Abstract

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