Human African Trypanosomiasis

Janelisa Musaya; Peter Nambala; Westain Tizgo Nyirenda; Julius Mulindwa; David Mabey

doi:10.1017/9781009052733.053

Human African Trypanosomiasis

Janelisa Musaya
, Peter Nambala
, Westain Tizgo Nyirenda
, Julius Mulindwa
, David Mabey

Clinical Sciences

Kamuzu University of Health Sciences
Malawi-Liverpool-Wellcome Trust Clinical Research Programme
Ministry of Health, Malawi
Makerere University
London School of Hygiene and Tropical Medicine

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

Abstract

Human African trypanosomiasis (HAT), otherwise known as sleeping sickness, comes in two forms: the West African form caused by Trypanosoma brucei gambiense, which is found in West and Central Africa, accounts for 95% of cases and has no known animal reservoir; and the East African form caused by Trypanosoma brucei rhodesiense, a zoonotic infection, which contributes 5%. HAT is endemic in 36 countries in sub-Saharan Africa (Fig. 52.1), but more than 70% of cases reported in the past 10 years have been in the Democratic Republic of Congo. It is invariably fatal unless treated. The parasites are transmitted by tsetse flies of the Glossina palpalis and G. morsitans groups.

Original language	English
Title of host publication	Principles of Medicine in Africa
Publisher	Cambridge University Press (CUP)
Pages	518-523
Number of pages	6
Edition	5
ISBN (Electronic)	9781316511435
ISBN (Print)	9781009052733
DOIs	https://doi.org/10.1017/9781009052733.053
Publication status	Published - 18 Jun 2025

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

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10.1017/9781009052733.053

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abstract = "Human African trypanosomiasis (HAT), otherwise known as sleeping sickness, comes in two forms: the West African form caused by Trypanosoma brucei gambiense, which is found in West and Central Africa, accounts for 95\% of cases and has no known animal reservoir; and the East African form caused by Trypanosoma brucei rhodesiense, a zoonotic infection, which contributes 5\%. HAT is endemic in 36 countries in sub-Saharan Africa (Fig. 52.1), but more than 70\% of cases reported in the past 10 years have been in the Democratic Republic of Congo. It is invariably fatal unless treated. The parasites are transmitted by tsetse flies of the Glossina palpalis and G. morsitans groups.",

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AU - Musaya, Janelisa

AU - Nambala, Peter

AU - Nyirenda, Westain Tizgo

AU - Mulindwa, Julius

AU - Mabey, David

PY - 2025/6/18

Y1 - 2025/6/18

N2 - Human African trypanosomiasis (HAT), otherwise known as sleeping sickness, comes in two forms: the West African form caused by Trypanosoma brucei gambiense, which is found in West and Central Africa, accounts for 95% of cases and has no known animal reservoir; and the East African form caused by Trypanosoma brucei rhodesiense, a zoonotic infection, which contributes 5%. HAT is endemic in 36 countries in sub-Saharan Africa (Fig. 52.1), but more than 70% of cases reported in the past 10 years have been in the Democratic Republic of Congo. It is invariably fatal unless treated. The parasites are transmitted by tsetse flies of the Glossina palpalis and G. morsitans groups.

AB - Human African trypanosomiasis (HAT), otherwise known as sleeping sickness, comes in two forms: the West African form caused by Trypanosoma brucei gambiense, which is found in West and Central Africa, accounts for 95% of cases and has no known animal reservoir; and the East African form caused by Trypanosoma brucei rhodesiense, a zoonotic infection, which contributes 5%. HAT is endemic in 36 countries in sub-Saharan Africa (Fig. 52.1), but more than 70% of cases reported in the past 10 years have been in the Democratic Republic of Congo. It is invariably fatal unless treated. The parasites are transmitted by tsetse flies of the Glossina palpalis and G. morsitans groups.

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M3 - Chapter

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SN - 9781009052733

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EP - 523

BT - Principles of Medicine in Africa

PB - Cambridge University Press (CUP)

ER -

Human African Trypanosomiasis

Abstract

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