TY - JOUR
T1 - High Transmissibility During Early HIV Infection Among Men Who Have Sex With Men—San Francisco, California
AU - Hollingsworth, Deirdre
AU - Pilcher, Christopher
AU - Hecht, Frederick M
AU - Deeks, Steven G
AU - Fraser, Christophe
PY - 2014/12/26
Y1 - 2014/12/26
N2 - We estimate the relative transmission rate in early versus later infection among men who have sex with men (MSM) in San Francisco, California, by studying the characteristics of a sample of transmitters, recruited through newly diagnosed, recently infected MSM between 1996 and 2009. Of 36 transmitters identified, 9 were determined on the basis of testing history and serologic testing to have been recently infected. The unadjusted odds ratio of transmitting during early infection was 15.2 (95% confidence interval [CI], 6.3–33.4; P < .001); the odds ratio was 8.9 (95% CI, 4.1–19.4) after adjustment for self-reported antiretroviral treatment. This high transmissibility could be due to both high infectiousness and high rates of sex partner change or concurrent partnerships.
AB - We estimate the relative transmission rate in early versus later infection among men who have sex with men (MSM) in San Francisco, California, by studying the characteristics of a sample of transmitters, recruited through newly diagnosed, recently infected MSM between 1996 and 2009. Of 36 transmitters identified, 9 were determined on the basis of testing history and serologic testing to have been recently infected. The unadjusted odds ratio of transmitting during early infection was 15.2 (95% confidence interval [CI], 6.3–33.4; P < .001); the odds ratio was 8.9 (95% CI, 4.1–19.4) after adjustment for self-reported antiretroviral treatment. This high transmissibility could be due to both high infectiousness and high rates of sex partner change or concurrent partnerships.
KW - early infection
KW - HIV
KW - men who have sex with men
KW - San Francisco
KW - transmission rate
U2 - 10.1093/infdis/jiu831
DO - 10.1093/infdis/jiu831
M3 - Article
SN - 0022-1899
VL - 211
SP - 1757
EP - 1760
JO - Journal of Infectious Diseases
JF - Journal of Infectious Diseases
IS - 11
ER -
