High early death rate in tuberculosis patients in Malawi

A. D. Harries; N.J. Hargreaves; F. Gausi; J. H. Kwanjana; F. M. Salaniponi

High early death rate in tuberculosis patients in Malawi

A. D. Harries, N.J. Hargreaves, F. Gausi, J. H. Kwanjana, F. M. Salaniponi

Liverpool School of Tropical Medicine

Research output: Contribution to journal › Article › peer-review

93 Citations (Scopus)

Abstract

SETTING: Thirty-eight district and mission hospitals in Malawi.

OBJECTIVES: In patients registered with all types of tuberculosis (TB) in 1997 to determine 1) treatment outcomes, and 2) when in the course of anti-tuberculosis treatment TB deaths occurred.

DESIGN: A retrospective study using information from TB registers, health centre registers, TB treatment cards and TB ward admission books.

RESULTS: A total of 16004 patients were registered with all types of TB, 6471 with smear-positive pulmonary tuberculosis (PTB), 5305 with smear-negative PTB and 4228 with extra-pulmonary tuberculosis (EPTB). Of patients with all types of TB, 3720 (23%) died: death rates were 22% in smear-positive PTB, 26% in smear-negative PTB and 22% in EPTB. Month of death was known in 3371 patients (91% of those who died) and day of death in 3326 patients (89% of those who died). In patients who died, 19% of deaths occurred by day 7 and 41% by the end of the first month of treatment. A higher proportion of early deaths occurred in patients with smear-negative PTB and EPTB and in relation to increasing age.

CONCLUSIONS: There was a high overall death rate in TB patients registered in 1997, with 40% of deaths occurring in the first month of treatment. Strategies to combat this problem are needed.

Original language	English
Pages (from-to)	1000-1005
Number of pages	6
Journal	International Journal of Tuberculosis and Lung Disease
Volume	5
Issue number	11
Publication status	Published - 1 Nov 2001

Keywords

Early deaths
Malawi
Tuberculosis

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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Harries, A. D., Hargreaves, N. J., Gausi, F., Kwanjana, J. H., & Salaniponi, F. M. (2001). High early death rate in tuberculosis patients in Malawi. International Journal of Tuberculosis and Lung Disease, 5(11), 1000-1005. http://www.ingentaconnect.com/content/iuatld/ijtld/2001/00000005/00000011/art00004?token=004119d4270a33cfc67232d45232b5f24313842573166473e283568263c7bc786

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abstract = "SETTING: Thirty-eight district and mission hospitals in Malawi. OBJECTIVES: In patients registered with all types of tuberculosis (TB) in 1997 to determine 1) treatment outcomes, and 2) when in the course of anti-tuberculosis treatment TB deaths occurred. DESIGN: A retrospective study using information from TB registers, health centre registers, TB treatment cards and TB ward admission books. RESULTS: A total of 16004 patients were registered with all types of TB, 6471 with smear-positive pulmonary tuberculosis (PTB), 5305 with smear-negative PTB and 4228 with extra-pulmonary tuberculosis (EPTB). Of patients with all types of TB, 3720 (23\%) died: death rates were 22\% in smear-positive PTB, 26\% in smear-negative PTB and 22\% in EPTB. Month of death was known in 3371 patients (91\% of those who died) and day of death in 3326 patients (89\% of those who died). In patients who died, 19\% of deaths occurred by day 7 and 41\% by the end of the first month of treatment. A higher proportion of early deaths occurred in patients with smear-negative PTB and EPTB and in relation to increasing age. CONCLUSIONS: There was a high overall death rate in TB patients registered in 1997, with 40\% of deaths occurring in the first month of treatment. Strategies to combat this problem are needed.",

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Harries, AD, Hargreaves, NJ, Gausi, F, Kwanjana, JH & Salaniponi, FM 2001, 'High early death rate in tuberculosis patients in Malawi', International Journal of Tuberculosis and Lung Disease, vol. 5, no. 11, pp. 1000-1005. <http://www.ingentaconnect.com/content/iuatld/ijtld/2001/00000005/00000011/art00004?token=004119d4270a33cfc67232d45232b5f24313842573166473e283568263c7bc786>

TY - JOUR

T1 - High early death rate in tuberculosis patients in Malawi

AU - Harries, A. D.

AU - Hargreaves, N.J.

AU - Gausi, F.

AU - Kwanjana, J. H.

AU - Salaniponi, F. M.

PY - 2001/11/1

Y1 - 2001/11/1

N2 - SETTING: Thirty-eight district and mission hospitals in Malawi. OBJECTIVES: In patients registered with all types of tuberculosis (TB) in 1997 to determine 1) treatment outcomes, and 2) when in the course of anti-tuberculosis treatment TB deaths occurred. DESIGN: A retrospective study using information from TB registers, health centre registers, TB treatment cards and TB ward admission books. RESULTS: A total of 16004 patients were registered with all types of TB, 6471 with smear-positive pulmonary tuberculosis (PTB), 5305 with smear-negative PTB and 4228 with extra-pulmonary tuberculosis (EPTB). Of patients with all types of TB, 3720 (23%) died: death rates were 22% in smear-positive PTB, 26% in smear-negative PTB and 22% in EPTB. Month of death was known in 3371 patients (91% of those who died) and day of death in 3326 patients (89% of those who died). In patients who died, 19% of deaths occurred by day 7 and 41% by the end of the first month of treatment. A higher proportion of early deaths occurred in patients with smear-negative PTB and EPTB and in relation to increasing age. CONCLUSIONS: There was a high overall death rate in TB patients registered in 1997, with 40% of deaths occurring in the first month of treatment. Strategies to combat this problem are needed.

AB - SETTING: Thirty-eight district and mission hospitals in Malawi. OBJECTIVES: In patients registered with all types of tuberculosis (TB) in 1997 to determine 1) treatment outcomes, and 2) when in the course of anti-tuberculosis treatment TB deaths occurred. DESIGN: A retrospective study using information from TB registers, health centre registers, TB treatment cards and TB ward admission books. RESULTS: A total of 16004 patients were registered with all types of TB, 6471 with smear-positive pulmonary tuberculosis (PTB), 5305 with smear-negative PTB and 4228 with extra-pulmonary tuberculosis (EPTB). Of patients with all types of TB, 3720 (23%) died: death rates were 22% in smear-positive PTB, 26% in smear-negative PTB and 22% in EPTB. Month of death was known in 3371 patients (91% of those who died) and day of death in 3326 patients (89% of those who died). In patients who died, 19% of deaths occurred by day 7 and 41% by the end of the first month of treatment. A higher proportion of early deaths occurred in patients with smear-negative PTB and EPTB and in relation to increasing age. CONCLUSIONS: There was a high overall death rate in TB patients registered in 1997, with 40% of deaths occurring in the first month of treatment. Strategies to combat this problem are needed.

KW - Early deaths

KW - Malawi

KW - Tuberculosis

M3 - Article

SN - 1027-3719

VL - 5

SP - 1000

EP - 1005

JO - International Journal of Tuberculosis and Lung Disease

JF - International Journal of Tuberculosis and Lung Disease

IS - 11

ER -

High early death rate in tuberculosis patients in Malawi

Abstract

Keywords

UN SDGs

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