High burden of Schistosoma mansoni infection in school-aged children in Marolambo District, Madagascar

Stephen Spencer; James M.St John Penney; Hannah J. Russell; Anthony P. Howe; Cortland Linder; Andriamahitsisambatra L.D. Rakotomampianina; Anjara M. Nandimbiniaina; Bertie Squire; Russell Stothard; Amaya L. Bustinduy; Alain M. Rahetilahy

doi:10.1186/s13071-017-2249-7

High burden of Schistosoma mansoni infection in school-aged children in Marolambo District, Madagascar

Stephen Spencer
, James M.St John Penney
, Hannah J. Russell
, Anthony P. Howe
, Cortland Linder
, Andriamahitsisambatra L.D. Rakotomampianina
, Anjara M. Nandimbiniaina
, Bertie Squire
, Russell Stothard
, Amaya L. Bustinduy
, Alain M. Rahetilahy

Research output: Contribution to journal › Article › peer-review

27 Citations (Scopus)

Abstract

Background

A school-based survey was undertaken to assess prevalence and infection intensity of schistosomiasis in school-aged children in the Marolambo District of Madagascar.

Methods

School-aged children from six purposively selected schools were tested for Schistosoma haematobium by urine filtration and Schistosoma mansoni using circulating cathodic antigen (CCA) and Kato-Katz stool analysis. The investigators did not address soil-transmitted helminths (STH) in this study.

Results

Of 399 school-aged children screened, 93.7% were infected with S. mansoni based on CCA analysis. Kato-Katz analysis of stool revealed S. mansoni infection in 73.6% (215/ 292). Heavy infections (> 400 eggs per gram) were common (32.1%; 69/ 215), with a mean of 482 eggs per gram of stool. Moderate infection intensities were detected in 31.2% (67/ 215) and light infection intensities in 36.7% (79/ 215) of infected participants. No infection with S. haematobium was detected by urine filtration.

Conclusions

Intestinal schistosomiasis appears a considerable public health issue in this remote area of Madagascar where there is a pressing need for mass drug administration.

Original language	English
Article number	307
Journal	Parasites and Vectors
Volume	10
Issue number	1
DOIs	https://doi.org/10.1186/s13071-017-2249-7
Publication status	Published - 24 Jun 2017

Keywords

Child health
Madagascar
Neglected diseases
Rural health
Schistosoma mansoni
Schistosomiasis

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1186/s13071-017-2249-7Licence: CC BY

Para and Vect High burden of Schistosoma mansoniFinal published version, 625 KBLicence: CC BY

Cite this

Spencer, S., Penney, J. M. S. J., Russell, H. J., Howe, A. P., Linder, C., Rakotomampianina, A. L. D., Nandimbiniaina, A. M., Squire, B., Stothard, R., Bustinduy, A. L., & Rahetilahy, A. M. (2017). High burden of Schistosoma mansoni infection in school-aged children in Marolambo District, Madagascar. Parasites and Vectors, 10(1), Article 307. https://doi.org/10.1186/s13071-017-2249-7

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title = "High burden of Schistosoma mansoni infection in school-aged children in Marolambo District, Madagascar",

abstract = "BackgroundA school-based survey was undertaken to assess prevalence and infection intensity of schistosomiasis in school-aged children in the Marolambo District of Madagascar.MethodsSchool-aged children from six purposively selected schools were tested for Schistosoma haematobium by urine filtration and Schistosoma mansoni using circulating cathodic antigen (CCA) and Kato-Katz stool analysis. The investigators did not address soil-transmitted helminths (STH) in this study.ResultsOf 399 school-aged children screened, 93.7\% were infected with S. mansoni based on CCA analysis. Kato-Katz analysis of stool revealed S. mansoni infection in 73.6\% (215/ 292). Heavy infections (> 400 eggs per gram) were common (32.1\%; 69/ 215), with a mean of 482 eggs per gram of stool. Moderate infection intensities were detected in 31.2\% (67/ 215) and light infection intensities in 36.7\% (79/ 215) of infected participants. No infection with S. haematobium was detected by urine filtration.ConclusionsIntestinal schistosomiasis appears a considerable public health issue in this remote area of Madagascar where there is a pressing need for mass drug administration.",

keywords = "Child health, Madagascar, Neglected diseases, Rural health, Schistosoma mansoni, Schistosomiasis",

author = "Stephen Spencer and Penney, \{James M.St John\} and Russell, \{Hannah J.\} and Howe, \{Anthony P.\} and Cortland Linder and Rakotomampianina, \{Andriamahitsisambatra L.D.\} and Nandimbiniaina, \{Anjara M.\} and Bertie Squire and Russell Stothard and Bustinduy, \{Amaya L.\} and Rahetilahy, \{Alain M.\}",

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month = jun,

day = "24",

doi = "10.1186/s13071-017-2249-7",

language = "English",

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journal = "Parasites and Vectors",

issn = "1756-3305",

publisher = "BioMed Central Ltd",

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T1 - High burden of Schistosoma mansoni infection in school-aged children in Marolambo District, Madagascar

AU - Spencer, Stephen

AU - Penney, James M.St John

AU - Russell, Hannah J.

AU - Howe, Anthony P.

AU - Linder, Cortland

AU - Rakotomampianina, Andriamahitsisambatra L.D.

AU - Nandimbiniaina, Anjara M.

AU - Squire, Bertie

AU - Stothard, Russell

AU - Bustinduy, Amaya L.

AU - Rahetilahy, Alain M.

PY - 2017/6/24

Y1 - 2017/6/24

N2 - BackgroundA school-based survey was undertaken to assess prevalence and infection intensity of schistosomiasis in school-aged children in the Marolambo District of Madagascar.MethodsSchool-aged children from six purposively selected schools were tested for Schistosoma haematobium by urine filtration and Schistosoma mansoni using circulating cathodic antigen (CCA) and Kato-Katz stool analysis. The investigators did not address soil-transmitted helminths (STH) in this study.ResultsOf 399 school-aged children screened, 93.7% were infected with S. mansoni based on CCA analysis. Kato-Katz analysis of stool revealed S. mansoni infection in 73.6% (215/ 292). Heavy infections (> 400 eggs per gram) were common (32.1%; 69/ 215), with a mean of 482 eggs per gram of stool. Moderate infection intensities were detected in 31.2% (67/ 215) and light infection intensities in 36.7% (79/ 215) of infected participants. No infection with S. haematobium was detected by urine filtration.ConclusionsIntestinal schistosomiasis appears a considerable public health issue in this remote area of Madagascar where there is a pressing need for mass drug administration.

AB - BackgroundA school-based survey was undertaken to assess prevalence and infection intensity of schistosomiasis in school-aged children in the Marolambo District of Madagascar.MethodsSchool-aged children from six purposively selected schools were tested for Schistosoma haematobium by urine filtration and Schistosoma mansoni using circulating cathodic antigen (CCA) and Kato-Katz stool analysis. The investigators did not address soil-transmitted helminths (STH) in this study.ResultsOf 399 school-aged children screened, 93.7% were infected with S. mansoni based on CCA analysis. Kato-Katz analysis of stool revealed S. mansoni infection in 73.6% (215/ 292). Heavy infections (> 400 eggs per gram) were common (32.1%; 69/ 215), with a mean of 482 eggs per gram of stool. Moderate infection intensities were detected in 31.2% (67/ 215) and light infection intensities in 36.7% (79/ 215) of infected participants. No infection with S. haematobium was detected by urine filtration.ConclusionsIntestinal schistosomiasis appears a considerable public health issue in this remote area of Madagascar where there is a pressing need for mass drug administration.

KW - Child health

KW - Madagascar

KW - Neglected diseases

KW - Rural health

KW - Schistosoma mansoni

KW - Schistosomiasis

U2 - 10.1186/s13071-017-2249-7

DO - 10.1186/s13071-017-2249-7

M3 - Article

SN - 1756-3305

VL - 10

JO - Parasites and Vectors

JF - Parasites and Vectors

IS - 1

M1 - 307

ER -

High burden of Schistosoma mansoni infection in school-aged children in Marolambo District, Madagascar

Abstract

Keywords

UN SDGs

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