Healthcare-associated Crimean-Congo haemorrhagic fever in Turkey, 2002–2014: a multicentre retrospective cross-sectional study

H. Leblebicioglu; M. Sunbul; R. Guner; H. Bodur; C. Bulut; F. Duygu; N. Elaldi; G. Cicek Senturk; Z. Ozkurt; G. Yilmaz; Tom Fletcher; Nicholas Beeching

doi:10.1016/j.cmi.2015.11.024

Healthcare-associated Crimean-Congo haemorrhagic fever in Turkey, 2002–2014: a multicentre retrospective cross-sectional study

H. Leblebicioglu
, M. Sunbul
, R. Guner
, H. Bodur
, C. Bulut
, F. Duygu
, N. Elaldi
, G. Cicek Senturk
, Z. Ozkurt
, G. Yilmaz
, Tom Fletcher
, Nicholas Beeching

Ondokuz Mayis University
Yildirim Beyazit Universitesi
Ankara Numune Education and Research Hospital
Ankara Research and Training Hospital
Gaziosmanpasa University
Cumhuriyet University
Ministry of Health, Turkey
Ataturk University
Karadeniz Technical University
University of Liverpool

Research output: Contribution to journal › Article › peer-review

70 Citations (Scopus)

Abstract

Healthcare-related transmission of Crimean-Congo haemorrhagic fever (CCHF) is a well-recognized hazard. We report a multicentre retrospective cross-sectional study undertaken in Turkey in 2014 in nine hospitals, regional reference centres for CCHF, covering the years 2002 to 2014 inclusive. Data were systematically extracted from charts of all personnel with a reported health care injury/accident related to CCHF. Blood samples were tested for CCHF IgM/IgG by enzyme-linked immunosorbent assay and/or viral nucleic acid detection by PCR after the injury. Fifty-one healthcare-related exposures were identified. Twenty-five (49%) of 51 resulted in laboratory-confirmed infection, with a 16% (4/25) overall mortality. The main route of exposure was needlestick injury in 32/51 (62.7%). A potential benefit of post-exposure prophylaxis with ribavirin was identified.

Original language	English
Pages (from-to)	387.e1-387.e4
Journal	Clinical Microbiology and Infection
Volume	22
Issue number	4
DOIs	https://doi.org/10.1016/j.cmi.2015.11.024
Publication status	Published - 20 Jan 2016

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Crimean-Congo haemorrhagic fever
Healthcare associated
Infection prevention and control
Ribavirin
Viral haemorrhagic fever

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10.1016/j.cmi.2015.11.024Licence: CC BY

Cite this

Leblebicioglu, H., Sunbul, M., Guner, R., Bodur, H., Bulut, C., Duygu, F., Elaldi, N., Cicek Senturk, G., Ozkurt, Z., Yilmaz, G., Fletcher, T., & Beeching, N. (2016). Healthcare-associated Crimean-Congo haemorrhagic fever in Turkey, 2002–2014: a multicentre retrospective cross-sectional study. Clinical Microbiology and Infection, 22(4), 387.e1-387.e4. https://doi.org/10.1016/j.cmi.2015.11.024

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title = "Healthcare-associated Crimean-Congo haemorrhagic fever in Turkey, 2002–2014: a multicentre retrospective cross-sectional study",

abstract = "Healthcare-related transmission of Crimean-Congo haemorrhagic fever (CCHF) is a well-recognized hazard. We report a multicentre retrospective cross-sectional study undertaken in Turkey in 2014 in nine hospitals, regional reference centres for CCHF, covering the years 2002 to 2014 inclusive. Data were systematically extracted from charts of all personnel with a reported health care injury/accident related to CCHF. Blood samples were tested for CCHF IgM/IgG by enzyme-linked immunosorbent assay and/or viral nucleic acid detection by PCR after the injury. Fifty-one healthcare-related exposures were identified. Twenty-five (49\%) of 51 resulted in laboratory-confirmed infection, with a 16\% (4/25) overall mortality. The main route of exposure was needlestick injury in 32/51 (62.7\%). A potential benefit of post-exposure prophylaxis with ribavirin was identified.",

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Leblebicioglu, H, Sunbul, M, Guner, R, Bodur, H, Bulut, C, Duygu, F, Elaldi, N, Cicek Senturk, G, Ozkurt, Z, Yilmaz, G, Fletcher, T & Beeching, N 2016, 'Healthcare-associated Crimean-Congo haemorrhagic fever in Turkey, 2002–2014: a multicentre retrospective cross-sectional study', Clinical Microbiology and Infection, vol. 22, no. 4, pp. 387.e1-387.e4. https://doi.org/10.1016/j.cmi.2015.11.024

TY - JOUR

T1 - Healthcare-associated Crimean-Congo haemorrhagic fever in Turkey, 2002–2014: a multicentre retrospective cross-sectional study

AU - Leblebicioglu, H.

AU - Sunbul, M.

AU - Guner, R.

AU - Bodur, H.

AU - Bulut, C.

AU - Duygu, F.

AU - Elaldi, N.

AU - Cicek Senturk, G.

AU - Ozkurt, Z.

AU - Yilmaz, G.

AU - Fletcher, Tom

AU - Beeching, Nicholas

PY - 2016/1/20

Y1 - 2016/1/20

N2 - Healthcare-related transmission of Crimean-Congo haemorrhagic fever (CCHF) is a well-recognized hazard. We report a multicentre retrospective cross-sectional study undertaken in Turkey in 2014 in nine hospitals, regional reference centres for CCHF, covering the years 2002 to 2014 inclusive. Data were systematically extracted from charts of all personnel with a reported health care injury/accident related to CCHF. Blood samples were tested for CCHF IgM/IgG by enzyme-linked immunosorbent assay and/or viral nucleic acid detection by PCR after the injury. Fifty-one healthcare-related exposures were identified. Twenty-five (49%) of 51 resulted in laboratory-confirmed infection, with a 16% (4/25) overall mortality. The main route of exposure was needlestick injury in 32/51 (62.7%). A potential benefit of post-exposure prophylaxis with ribavirin was identified.

AB - Healthcare-related transmission of Crimean-Congo haemorrhagic fever (CCHF) is a well-recognized hazard. We report a multicentre retrospective cross-sectional study undertaken in Turkey in 2014 in nine hospitals, regional reference centres for CCHF, covering the years 2002 to 2014 inclusive. Data were systematically extracted from charts of all personnel with a reported health care injury/accident related to CCHF. Blood samples were tested for CCHF IgM/IgG by enzyme-linked immunosorbent assay and/or viral nucleic acid detection by PCR after the injury. Fifty-one healthcare-related exposures were identified. Twenty-five (49%) of 51 resulted in laboratory-confirmed infection, with a 16% (4/25) overall mortality. The main route of exposure was needlestick injury in 32/51 (62.7%). A potential benefit of post-exposure prophylaxis with ribavirin was identified.

KW - Crimean-Congo haemorrhagic fever

KW - Healthcare associated

KW - Infection prevention and control

KW - Ribavirin

KW - Viral haemorrhagic fever

U2 - 10.1016/j.cmi.2015.11.024

DO - 10.1016/j.cmi.2015.11.024

M3 - Article

SN - 1198-743X

VL - 22

SP - 387.e1-387.e4

JO - Clinical Microbiology and Infection

JF - Clinical Microbiology and Infection

IS - 4

ER -

Healthcare-associated Crimean-Congo haemorrhagic fever in Turkey, 2002–2014: a multicentre retrospective cross-sectional study

Abstract

UN SDGs

Keywords

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