TY - JOUR
T1 - Guidance for conducting and evaluating serological surveys to assess interruption of yaws transmission in the context of an eradication target
AU - Mitjà, Oriol
AU - Gass, Katherine
AU - Marks, Michael
AU - Cooper, Philip
AU - Diggle, Peter
AU - Waller, Lance
AU - Agana-Nsiire, Patrick
AU - Dofitas, Belen Lardizabal
AU - Dyson, Louise
AU - Jacobson, Julie
AU - Kaldor, John
AU - Kim, Sung Hye
AU - Vaz Nery, Susana
AU - Revankar, Chandrakant
AU - Sopoh, Ghislain
AU - Solomon, Anthony W.
AU - Dagne, Daniel Argaw
AU - Pathak, Priya
AU - Yajima, Aya
AU - Lin, Zaw
AU - Barogui, Mahoutondji Yves Thierry
AU - Scholte, Ronaldo Carvalho
AU - Sanikullah, Kazim Hizbullah
AU - Drakeley, Chris
AU - Stresman, Gillian
AU - Gyapong, John
AU - Asiedu, Kingsley Bampoe
PY - 2025/4/23
Y1 - 2025/4/23
N2 - This document provides a summary of guidance developed for national programmes on conducting serosurveys to assess yaws transmission status, with the objective of confirming yaws seroprevalence below 1% at each of three serosurveys over a period of 3–10 years after reporting the last case of active yaws in a region. It proposes active testing of children aged 1–5 years through population-based surveys and includes recommendations on survey design, sample size determination, sampling of primary sampling units (PSUs) within an evaluation unit, sampling of households within PSUs, integration with existing public health surveys, and follow-up protocols for positive results. Geospatial analysis and sustained surveillance are recommended for accurate assessment of whether transmission interruption has been achieved.
AB - This document provides a summary of guidance developed for national programmes on conducting serosurveys to assess yaws transmission status, with the objective of confirming yaws seroprevalence below 1% at each of three serosurveys over a period of 3–10 years after reporting the last case of active yaws in a region. It proposes active testing of children aged 1–5 years through population-based surveys and includes recommendations on survey design, sample size determination, sampling of primary sampling units (PSUs) within an evaluation unit, sampling of households within PSUs, integration with existing public health surveys, and follow-up protocols for positive results. Geospatial analysis and sustained surveillance are recommended for accurate assessment of whether transmission interruption has been achieved.
U2 - 10.1371/journal.pntd.0012899
DO - 10.1371/journal.pntd.0012899
M3 - Review article
VL - 19
JO - PLOS Neglected Tropical Diseases
JF - PLOS Neglected Tropical Diseases
IS - 4
M1 - e0012899
ER -
