Glucose-6-phosphate dehydrogenase status and risk of hemolysis in Plasmodium falciparum-infected African children receiving single-dose primaquine

Alice C. Eziefula; Helmi Pett; Lynn Grignard; Salome Opus; Moses Kiggundu; Moses R. Kamya; Shunmay Yeung; Sarah Staedke; Teun Bousema; Chris Drakeley

doi:10.1128/aac.02889-14

Glucose-6-phosphate dehydrogenase status and risk of hemolysis in Plasmodium falciparum-infected African children receiving single-dose primaquine

Alice C. Eziefula, Helmi Pett, Lynn Grignard, Salome Opus, Moses Kiggundu, Moses R. Kamya, Shunmay Yeung, Sarah Staedke, Teun Bousema, Chris Drakeley

Research output: Contribution to journal › Article › peer-review

28 Citations (Scopus)

Abstract

Glucose-6-phosphate dehydrogenase (G6PD) enzyme function and genotype were determined in Ugandan children with uncomplicated falciparum malaria enrolled in a primaquine trial after exclusion of severe G6PD deficiency by fluorescent spot test. G6PD A-heterozygotes and hemizygotes/homozygotes experienced dose-dependent lower hemoglobin concentrations after treatment. No severe anemia was observed.

Original language	English
Pages (from-to)	4971-4973
Number of pages	3
Journal	Antimicrobial Agents and Chemotherapy
Volume	58
Issue number	8
DOIs	https://doi.org/10.1128/aac.02889-14
Publication status	Published - 1 Aug 2014
Externally published	Yes

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Eziefula, A. C., Pett, H., Grignard, L., Opus, S., Kiggundu, M., Kamya, M. R., Yeung, S., Staedke, S., Bousema, T., & Drakeley, C. (2014). Glucose-6-phosphate dehydrogenase status and risk of hemolysis in Plasmodium falciparum-infected African children receiving single-dose primaquine. Antimicrobial Agents and Chemotherapy, 58(8), 4971-4973. https://doi.org/10.1128/aac.02889-14

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abstract = "Glucose-6-phosphate dehydrogenase (G6PD) enzyme function and genotype were determined in Ugandan children with uncomplicated falciparum malaria enrolled in a primaquine trial after exclusion of severe G6PD deficiency by fluorescent spot test. G6PD A-heterozygotes and hemizygotes/homozygotes experienced dose-dependent lower hemoglobin concentrations after treatment. No severe anemia was observed.",

author = "Eziefula, \{Alice C.\} and Helmi Pett and Lynn Grignard and Salome Opus and Moses Kiggundu and Kamya, \{Moses R.\} and Shunmay Yeung and Sarah Staedke and Teun Bousema and Chris Drakeley",

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Eziefula, AC, Pett, H, Grignard, L, Opus, S, Kiggundu, M, Kamya, MR, Yeung, S, Staedke, S, Bousema, T & Drakeley, C 2014, 'Glucose-6-phosphate dehydrogenase status and risk of hemolysis in Plasmodium falciparum-infected African children receiving single-dose primaquine', Antimicrobial Agents and Chemotherapy, vol. 58, no. 8, pp. 4971-4973. https://doi.org/10.1128/aac.02889-14

TY - JOUR

T1 - Glucose-6-phosphate dehydrogenase status and risk of hemolysis in Plasmodium falciparum-infected African children receiving single-dose primaquine

AU - Eziefula, Alice C.

AU - Pett, Helmi

AU - Grignard, Lynn

AU - Opus, Salome

AU - Kiggundu, Moses

AU - Kamya, Moses R.

AU - Yeung, Shunmay

AU - Staedke, Sarah

AU - Bousema, Teun

AU - Drakeley, Chris

PY - 2014/8/1

Y1 - 2014/8/1

N2 - Glucose-6-phosphate dehydrogenase (G6PD) enzyme function and genotype were determined in Ugandan children with uncomplicated falciparum malaria enrolled in a primaquine trial after exclusion of severe G6PD deficiency by fluorescent spot test. G6PD A-heterozygotes and hemizygotes/homozygotes experienced dose-dependent lower hemoglobin concentrations after treatment. No severe anemia was observed.

AB - Glucose-6-phosphate dehydrogenase (G6PD) enzyme function and genotype were determined in Ugandan children with uncomplicated falciparum malaria enrolled in a primaquine trial after exclusion of severe G6PD deficiency by fluorescent spot test. G6PD A-heterozygotes and hemizygotes/homozygotes experienced dose-dependent lower hemoglobin concentrations after treatment. No severe anemia was observed.

U2 - 10.1128/aac.02889-14

DO - 10.1128/aac.02889-14

M3 - Article

SN - 0066-4804

VL - 58

SP - 4971

EP - 4973

JO - Antimicrobial Agents and Chemotherapy

JF - Antimicrobial Agents and Chemotherapy

IS - 8

ER -

Glucose-6-phosphate dehydrogenase status and risk of hemolysis in Plasmodium falciparum-infected African children receiving single-dose primaquine

Abstract

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