Genomic assessment of quarantine measures to prevent SARS-CoV-2 importation and transmission

Dinesh Aggarwal; Andrew J. Page; Ulf Schaefer; George M. Savva; Richard Myers; Erik Volz; Nicholas Ellaby; Steven Platt; Natalie Groves; Eileen Gallagher; Niamh M. Tumelty; Thanh Le Viet; Gareth J. Hughes; Cong Chen; Charlie Turner; Sophie Logan; Abbie Harrison; Cherian Koshy; Amy Ash; Emma Wise; Nathan Moore; Matilde Mori; Nick Cortes; Jessica Lynch; Stephen Kidd; Derek J. Fairley; Tanya Curran; James P. McKenna; Helen Adams; Christophe Fraser; Tanya Golubchik; David Bonsall; Mohammed O. Hassan-Ibrahim; Cassandra S. Malone; Benjamin J. Cogger; Michelle Wantoch; Nicola Reynolds; Ben Warne; Joshua Maksimovic; Karla Spellman; Kathryn McCluggage; Michaela John; Robert Beer; Safiah Afifi; Sian Morgan; Angela Marchbank; Anna Price; Adam Westhorpe; Sally Forrest; Jonathan Ball

doi:10.1038/s41467-022-28371-z

Genomic assessment of quarantine measures to prevent SARS-CoV-2 importation and transmission

Dinesh Aggarwal, Andrew J. Page, Ulf Schaefer, George M. Savva, Richard Myers, Erik Volz, Nicholas Ellaby, Steven Platt, Natalie Groves, Eileen Gallagher, Niamh M. Tumelty, Thanh Le Viet, Gareth J. Hughes, Cong Chen, Charlie Turner, Sophie Logan, Abbie Harrison, Cherian Koshy, Amy Ash, Emma WiseNathan Moore, Matilde Mori, Nick Cortes, Jessica Lynch, Stephen Kidd, Derek J. Fairley, Tanya Curran, James P. McKenna, Helen Adams, Christophe Fraser, Tanya Golubchik, David Bonsall, Mohammed O. Hassan-Ibrahim, Cassandra S. Malone, Benjamin J. Cogger, Michelle Wantoch, Nicola Reynolds, Ben Warne, Joshua Maksimovic, Karla Spellman, Kathryn McCluggage, Michaela John, Robert Beer, Safiah Afifi, Sian Morgan, Angela Marchbank, Anna Price, Adam Westhorpe, Sally Forrest, Jonathan Ball

Research output: Contribution to journal › Article › peer-review

10 Citations (Scopus)

Abstract

Mitigation of SARS-CoV-2 transmission from international travel is a priority. We evaluated the effectiveness of travellers being required to quarantine for 14-days on return to England in Summer 2020. We identified 4,207 travel-related SARS-CoV-2 cases and their contacts, and identified 827 associated SARS-CoV-2 genomes. Overall, quarantine was associated with a lower rate of contacts, and the impact of quarantine was greatest in the 16–20 age-group. 186 SARS-CoV-2 genomes were sufficiently unique to identify travel-related clusters. Fewer genomically-linked cases were observed for index cases who returned from countries with quarantine requirement compared to countries with no quarantine requirement. This difference was explained by fewer importation events per identified genome for these cases, as opposed to fewer onward contacts per case. Overall, our study demonstrates that a 14-day quarantine period reduces, but does not completely eliminate, the onward transmission of imported cases, mainly by dissuading travel to countries with a quarantine requirement.

Original language	English
Article number	1012
Journal	Nature Communications
Volume	13
Issue number	1
DOIs	https://doi.org/10.1038/s41467-022-28371-z
Publication status	Published - 1 Dec 2022
Externally published	Yes

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Cite this

Aggarwal, D., Page, A. J., Schaefer, U., Savva, G. M., Myers, R., Volz, E., Ellaby, N., Platt, S., Groves, N., Gallagher, E., Tumelty, N. M., Le Viet, T., Hughes, G. J., Chen, C., Turner, C., Logan, S., Harrison, A., Koshy, C., Ash, A., ... Ball, J. (2022). Genomic assessment of quarantine measures to prevent SARS-CoV-2 importation and transmission. Nature Communications, 13(1), Article 1012. https://doi.org/10.1038/s41467-022-28371-z

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title = "Genomic assessment of quarantine measures to prevent SARS-CoV-2 importation and transmission",

abstract = "Mitigation of SARS-CoV-2 transmission from international travel is a priority. We evaluated the effectiveness of travellers being required to quarantine for 14-days on return to England in Summer 2020. We identified 4,207 travel-related SARS-CoV-2 cases and their contacts, and identified 827 associated SARS-CoV-2 genomes. Overall, quarantine was associated with a lower rate of contacts, and the impact of quarantine was greatest in the 16–20 age-group. 186 SARS-CoV-2 genomes were sufficiently unique to identify travel-related clusters. Fewer genomically-linked cases were observed for index cases who returned from countries with quarantine requirement compared to countries with no quarantine requirement. This difference was explained by fewer importation events per identified genome for these cases, as opposed to fewer onward contacts per case. Overall, our study demonstrates that a 14-day quarantine period reduces, but does not completely eliminate, the onward transmission of imported cases, mainly by dissuading travel to countries with a quarantine requirement.",

author = "Dinesh Aggarwal and Page, \{Andrew J.\} and Ulf Schaefer and Savva, \{George M.\} and Richard Myers and Erik Volz and Nicholas Ellaby and Steven Platt and Natalie Groves and Eileen Gallagher and Tumelty, \{Niamh M.\} and \{Le Viet\}, Thanh and Hughes, \{Gareth J.\} and Cong Chen and Charlie Turner and Sophie Logan and Abbie Harrison and Cherian Koshy and Amy Ash and Emma Wise and Nathan Moore and Matilde Mori and Nick Cortes and Jessica Lynch and Stephen Kidd and Fairley, \{Derek J.\} and Tanya Curran and McKenna, \{James P.\} and Helen Adams and Christophe Fraser and Tanya Golubchik and David Bonsall and Hassan-Ibrahim, \{Mohammed O.\} and Malone, \{Cassandra S.\} and Cogger, \{Benjamin J.\} and Michelle Wantoch and Nicola Reynolds and Ben Warne and Joshua Maksimovic and Karla Spellman and Kathryn McCluggage and Michaela John and Robert Beer and Safiah Afifi and Sian Morgan and Angela Marchbank and Anna Price and Adam Westhorpe and Sally Forrest and Jonathan Ball",

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Aggarwal, D, Page, AJ, Schaefer, U, Savva, GM, Myers, R, Volz, E, Ellaby, N, Platt, S, Groves, N, Gallagher, E, Tumelty, NM, Le Viet, T, Hughes, GJ, Chen, C, Turner, C, Logan, S, Harrison, A, Koshy, C, Ash, A, Wise, E, Moore, N, Mori, M, Cortes, N, Lynch, J, Kidd, S, Fairley, DJ, Curran, T, McKenna, JP, Adams, H, Fraser, C, Golubchik, T, Bonsall, D, Hassan-Ibrahim, MO, Malone, CS, Cogger, BJ, Wantoch, M, Reynolds, N, Warne, B, Maksimovic, J, Spellman, K, McCluggage, K, John, M, Beer, R, Afifi, S, Morgan, S, Marchbank, A, Price, A, Westhorpe, A, Forrest, S & Ball, J 2022, 'Genomic assessment of quarantine measures to prevent SARS-CoV-2 importation and transmission', Nature Communications, vol. 13, no. 1, 1012. https://doi.org/10.1038/s41467-022-28371-z

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AU - Aggarwal, Dinesh

AU - Page, Andrew J.

AU - Schaefer, Ulf

AU - Savva, George M.

AU - Myers, Richard

AU - Volz, Erik

AU - Ellaby, Nicholas

AU - Platt, Steven

AU - Groves, Natalie

AU - Gallagher, Eileen

AU - Tumelty, Niamh M.

AU - Le Viet, Thanh

AU - Hughes, Gareth J.

AU - Chen, Cong

AU - Turner, Charlie

AU - Logan, Sophie

AU - Harrison, Abbie

AU - Koshy, Cherian

AU - Ash, Amy

AU - Wise, Emma

AU - Moore, Nathan

AU - Mori, Matilde

AU - Cortes, Nick

AU - Lynch, Jessica

AU - Kidd, Stephen

AU - Fairley, Derek J.

AU - Curran, Tanya

AU - McKenna, James P.

AU - Adams, Helen

AU - Fraser, Christophe

AU - Golubchik, Tanya

AU - Bonsall, David

AU - Hassan-Ibrahim, Mohammed O.

AU - Malone, Cassandra S.

AU - Cogger, Benjamin J.

AU - Wantoch, Michelle

AU - Reynolds, Nicola

AU - Warne, Ben

AU - Maksimovic, Joshua

AU - Spellman, Karla

AU - McCluggage, Kathryn

AU - John, Michaela

AU - Beer, Robert

AU - Afifi, Safiah

AU - Morgan, Sian

AU - Marchbank, Angela

AU - Price, Anna

AU - Westhorpe, Adam

AU - Forrest, Sally

AU - Ball, Jonathan

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N2 - Mitigation of SARS-CoV-2 transmission from international travel is a priority. We evaluated the effectiveness of travellers being required to quarantine for 14-days on return to England in Summer 2020. We identified 4,207 travel-related SARS-CoV-2 cases and their contacts, and identified 827 associated SARS-CoV-2 genomes. Overall, quarantine was associated with a lower rate of contacts, and the impact of quarantine was greatest in the 16–20 age-group. 186 SARS-CoV-2 genomes were sufficiently unique to identify travel-related clusters. Fewer genomically-linked cases were observed for index cases who returned from countries with quarantine requirement compared to countries with no quarantine requirement. This difference was explained by fewer importation events per identified genome for these cases, as opposed to fewer onward contacts per case. Overall, our study demonstrates that a 14-day quarantine period reduces, but does not completely eliminate, the onward transmission of imported cases, mainly by dissuading travel to countries with a quarantine requirement.

AB - Mitigation of SARS-CoV-2 transmission from international travel is a priority. We evaluated the effectiveness of travellers being required to quarantine for 14-days on return to England in Summer 2020. We identified 4,207 travel-related SARS-CoV-2 cases and their contacts, and identified 827 associated SARS-CoV-2 genomes. Overall, quarantine was associated with a lower rate of contacts, and the impact of quarantine was greatest in the 16–20 age-group. 186 SARS-CoV-2 genomes were sufficiently unique to identify travel-related clusters. Fewer genomically-linked cases were observed for index cases who returned from countries with quarantine requirement compared to countries with no quarantine requirement. This difference was explained by fewer importation events per identified genome for these cases, as opposed to fewer onward contacts per case. Overall, our study demonstrates that a 14-day quarantine period reduces, but does not completely eliminate, the onward transmission of imported cases, mainly by dissuading travel to countries with a quarantine requirement.

U2 - 10.1038/s41467-022-28371-z

DO - 10.1038/s41467-022-28371-z

M3 - Article

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JO - Nature Communications

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