Genome-wide association study reveals a novel tuberculosis susceptibility locus in multiple East Asian and European populations

Xuling Chang; Zheng Li; Phan Vuong Khac Thai; Dang Thi Minh Ha; Nguyen Thuy Thuong Thuong; Denise Wee; Alya Sufiyah Binte Mohamed  Subhan; Matthew Silcocks; Cynthia Bin Eng Chee; Nguyen Thi Quynh Nhu; Chew-Kiat Heng; Yik Ying Teo; Amit Singhal; Stefan H Oehlers; Jian-Min Yuan; Woon-Puay Koh; Maxine Caws; Chiea Chuen Khor; Rajkumar Dorajoo; Sarah J Dunstan

doi:10.1186/s13073-026-01670-6

Genome-wide association study reveals a novel tuberculosis susceptibility locus in multiple East Asian and European populations

Xuling Chang
, Zheng Li
, Phan Vuong Khac Thai
, Dang Thi Minh Ha
, Nguyen Thuy Thuong Thuong
, Denise Wee
, Alya Sufiyah Binte Mohamed Subhan
, Matthew Silcocks
, Cynthia Bin Eng Chee
, Nguyen Thi Quynh Nhu
, Chew-Kiat Heng
, Yik Ying Teo
, Amit Singhal
, Stefan H Oehlers
, Jian-Min Yuan
, Woon-Puay Koh
, Maxine Caws
, Chiea Chuen Khor
, Rajkumar Dorajoo
, Sarah J Dunstan

Clinical Sciences

University of Melbourne
MOH Holdings Pte Ltd.
National University of Singapore
Agency for Science, Technology and Research, Singapore
Pham Ngoc Thach Hospital
Pham NgocThach Hospital
University of Oxford
Tan Tock Seng Hospital
Lee Kong Chian School of Medicine
University of Pittsburgh
School of Medicine/National University of Singapore
Birat Nepal Medical Trust

Research output: Contribution to journal › Article › peer-review

Abstract

Tuberculosis (TB) continues to be a leading cause of morbidity and mortality worldwide. Although numerous genome-wide association studies (GWAS) have explored TB susceptibility across various ethnic groups, multi-population replication of findings has been very limited, particularly outside the HLA region, and a significant portion of TB heritability remains unexplained.

Original language	English
Article number	71
Journal	Genome Medicine
Volume	18
Issue number	1
DOIs	https://doi.org/10.1186/s13073-026-01670-6
Publication status	Published - 27 May 2026

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Underrepresented populations
Infectious diseases
Genome-wide association study
Pulmonary tuberculosis
Non-HLA genetic locus

Themes

Tuberculosis and Antimicrobial Resistance

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s13073-026-01670-6Final published version, 2.24 MBLicence: CC BY

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Chang, X., Li, Z., Thai, P. V. K., Ha, D. T. M., Thuong, N. T. T., Wee, D., Subhan, A. S. B. M., Silcocks, M., Chee, C. B. E., Nhu, N. T. Q., Heng, C.-K., Teo, Y. Y., Singhal, A., Oehlers, S. H., Yuan, J.-M., Koh, W.-P., Caws, M., Khor, C. C., Dorajoo, R., & Dunstan, S. J. (2026). Genome-wide association study reveals a novel tuberculosis susceptibility locus in multiple East Asian and European populations. Genome Medicine, 18(1), Article 71. https://doi.org/10.1186/s13073-026-01670-6

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title = "Genome-wide association study reveals a novel tuberculosis susceptibility locus in multiple East Asian and European populations",

abstract = "Tuberculosis (TB) continues to be a leading cause of morbidity and mortality worldwide. Although numerous genome-wide association studies (GWAS) have explored TB susceptibility across various ethnic groups, multi-population replication of findings has been very limited, particularly outside the HLA region, and a significant portion of TB heritability remains unexplained.",

keywords = "Underrepresented populations, Infectious diseases, Genome-wide association study, Pulmonary tuberculosis, Non-HLA genetic locus",

author = "Xuling Chang and Zheng Li and Thai, \{Phan Vuong Khac\} and Ha, \{Dang Thi Minh\} and Thuong, \{Nguyen Thuy Thuong\} and Denise Wee and Subhan, \{Alya Sufiyah Binte Mohamed\} and Matthew Silcocks and Chee, \{Cynthia Bin Eng\} and Nhu, \{Nguyen Thi Quynh\} and Chew-Kiat Heng and Teo, \{Yik Ying\} and Amit Singhal and Oehlers, \{Stefan H\} and Jian-Min Yuan and Woon-Puay Koh and Maxine Caws and Khor, \{Chiea Chuen\} and Rajkumar Dorajoo and Dunstan, \{Sarah J\}",

year = "2026",

month = may,

day = "27",

doi = "10.1186/s13073-026-01670-6",

language = "English",

volume = "18",

journal = "Genome Medicine",

issn = "1756-994X",

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Chang, X, Li, Z, Thai, PVK, Ha, DTM, Thuong, NTT, Wee, D, Subhan, ASBM, Silcocks, M, Chee, CBE, Nhu, NTQ, Heng, C-K, Teo, YY, Singhal, A, Oehlers, SH, Yuan, J-M, Koh, W-P, Caws, M, Khor, CC, Dorajoo, R & Dunstan, SJ 2026, 'Genome-wide association study reveals a novel tuberculosis susceptibility locus in multiple East Asian and European populations', Genome Medicine, vol. 18, no. 1, 71. https://doi.org/10.1186/s13073-026-01670-6

TY - JOUR

T1 - Genome-wide association study reveals a novel tuberculosis susceptibility locus in multiple East Asian and European populations

AU - Chang, Xuling

AU - Li, Zheng

AU - Thai, Phan Vuong Khac

AU - Ha, Dang Thi Minh

AU - Thuong, Nguyen Thuy Thuong

AU - Wee, Denise

AU - Subhan, Alya Sufiyah Binte Mohamed

AU - Silcocks, Matthew

AU - Chee, Cynthia Bin Eng

AU - Nhu, Nguyen Thi Quynh

AU - Heng, Chew-Kiat

AU - Teo, Yik Ying

AU - Singhal, Amit

AU - Oehlers, Stefan H

AU - Yuan, Jian-Min

AU - Koh, Woon-Puay

AU - Caws, Maxine

AU - Khor, Chiea Chuen

AU - Dorajoo, Rajkumar

AU - Dunstan, Sarah J

PY - 2026/5/27

Y1 - 2026/5/27

N2 - Tuberculosis (TB) continues to be a leading cause of morbidity and mortality worldwide. Although numerous genome-wide association studies (GWAS) have explored TB susceptibility across various ethnic groups, multi-population replication of findings has been very limited, particularly outside the HLA region, and a significant portion of TB heritability remains unexplained.

AB - Tuberculosis (TB) continues to be a leading cause of morbidity and mortality worldwide. Although numerous genome-wide association studies (GWAS) have explored TB susceptibility across various ethnic groups, multi-population replication of findings has been very limited, particularly outside the HLA region, and a significant portion of TB heritability remains unexplained.

KW - Underrepresented populations

KW - Infectious diseases

KW - Genome-wide association study

KW - Pulmonary tuberculosis

KW - Non-HLA genetic locus

U2 - 10.1186/s13073-026-01670-6

DO - 10.1186/s13073-026-01670-6

M3 - Article

SN - 1756-994X

VL - 18

JO - Genome Medicine

JF - Genome Medicine

IS - 1

M1 - 71

ER -

Genome-wide association study reveals a novel tuberculosis susceptibility locus in multiple East Asian and European populations

Abstract

UN SDGs

Keywords

Themes

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Cite this