Genome-wide association study identifies multiple risk loci for renal cell carcinoma

Ghislaine Scelo; Mark P. Purdue; Kevin M. Brown; Mattias Johansson; Zhaoming Wang; Jeanette E. Eckel-Passow; Yuanqing Ye; Jonathan N. Hofmann; Jiyeon Choi; Matthieu Foll; Valerie Gaborieau; Mitchell J. Machiela; Leandro M. Colli; Peng Li; Joshua N. Sampson; Behnoush Abedi-Ardekani; Celine Besse; Helene Blanche; Anne Boland; Laurie Burdette; Amelie Chabrier; Geoffroy Durand; Florence Le Calvez-Kelm; Egor Prokhortchouk; Nivonirina Robinot; Konstantin G. Skryabin; Magdalena B. Wozniak; Meredith Yeager; Gordana Basta-Jovanovic; Zoran Dzamic; Lenka Foretova; Ivana Holcatova; Vladimir Janout; Dana Mates; Anush Mukeriya; Stefan Rascu; David Zaridze; Vladimir Bencko; Cezary Cybulski; Eleonora Fabianova; Viorel Jinga; Jolanta Lissowska; Jan Lubinski; Marie Navratilova; Peter Rudnai; Neonila Szeszenia-Dabrowska; Simone Benhamou; Geraldine Cancel-Tassin; Olivier Cussenot; Laura Baglietto; Heiner Boeing; Kay Tee Khaw; Elisabete Weiderpass; Borje Ljungberg; Raviprakash T. Sitaram; Fiona Bruinsma; Susan J. Jordan; Gianluca Severi; Ingrid Winship; Kristian Hveem; Lars J. Vatten; Tony Fletcher; Kvetoslava Koppova; Susanna C. Larsson; Alicja Wolk; Rosamonde E. Banks; Peter J. Selby; Douglas F. Easton; Paul Pharoah; Gabriella Andreotti; Laura E.Beane Freeman; Stella Koutros; Demetrius Albanes; Satu Männistö; Stephanie Weinstein; Peter E. Clark; Todd L. Edwards; Loren Lipworth; Susan M. Gapstur; Victoria L. Stevens; Hallie Carol; Matthew L. Freedman; Mark M. Pomerantz; Eunyoung Cho; Peter Kraft; Mark A. Preston; Kathryn M. Wilson; J. Michael Gaziano; Howard D. Sesso; Amanda Black; Neal D. Freedman; Wen Yi Huang; John G. Anema; Richard J. Kahnoski; Brian R. Lane; Sabrina L. Noyes; David Petillo; Bin Tean Teh; Ulrike Peters; Emily White; Garnet L. Anderson; Lisa Johnson; Juhua Luo; Julie Buring; I. Min Lee; Wong Ho Chow; Lee E. Moore; Christopher Wood; Timothy Eisen; Marc Henrion; James Larkin; Poulami Barman; Bradley C. Leibovich; Toni K. Choueiri; G. Mark Lathrop; Nathaniel Rothman; Jean Francois Deleuze; James D. McKay; Alexander S. Parker; Xifeng Wu; Richard S. Houlston; Paul Brennan; Stephen J. Chanock

doi:10.1038/ncomms15724

Genome-wide association study identifies multiple risk loci for renal cell carcinoma

Ghislaine Scelo
, Mark P. Purdue
, Kevin M. Brown
, Mattias Johansson
, Zhaoming Wang
, Jeanette E. Eckel-Passow
, Yuanqing Ye
, Jonathan N. Hofmann
, Jiyeon Choi
, Matthieu Foll
, Valerie Gaborieau
, Mitchell J. Machiela
, Leandro M. Colli
, Peng Li
, Joshua N. Sampson
, Behnoush Abedi-Ardekani
, Celine Besse
, Helene Blanche
, Anne Boland
, Laurie Burdette

Amelie Chabrier, Geoffroy Durand, Florence Le Calvez-Kelm, Egor Prokhortchouk, Nivonirina Robinot, Konstantin G. Skryabin, Magdalena B. Wozniak, Meredith Yeager, Gordana Basta-Jovanovic, Zoran Dzamic, Lenka Foretova, Ivana Holcatova, Vladimir Janout, Dana Mates, Anush Mukeriya, Stefan Rascu, David Zaridze, Vladimir Bencko, Cezary Cybulski, Eleonora Fabianova, Viorel Jinga, Jolanta Lissowska, Jan Lubinski, Marie Navratilova, Peter Rudnai, Neonila Szeszenia-Dabrowska, Simone Benhamou, Geraldine Cancel-Tassin, Olivier Cussenot, Laura Baglietto, Heiner Boeing, Kay Tee Khaw, Elisabete Weiderpass, Borje Ljungberg, Raviprakash T. Sitaram, Fiona Bruinsma, Susan J. Jordan, Gianluca Severi, Ingrid Winship, Kristian Hveem, Lars J. Vatten, Tony Fletcher, Kvetoslava Koppova, Susanna C. Larsson, Alicja Wolk, Rosamonde E. Banks, Peter J. Selby, Douglas F. Easton, Paul Pharoah, Gabriella Andreotti, Laura E.Beane Freeman, Stella Koutros, Demetrius Albanes, Satu Männistö, Stephanie Weinstein, Peter E. Clark, Todd L. Edwards, Loren Lipworth, Susan M. Gapstur, Victoria L. Stevens, Hallie Carol, Matthew L. Freedman, Mark M. Pomerantz, Eunyoung Cho, Peter Kraft, Mark A. Preston, Kathryn M. Wilson, J. Michael Gaziano, Howard D. Sesso, Amanda Black, Neal D. Freedman, Wen Yi Huang, John G. Anema, Richard J. Kahnoski, Brian R. Lane, Sabrina L. Noyes, David Petillo, Bin Tean Teh, Ulrike Peters, Emily White, Garnet L. Anderson, Lisa Johnson, Juhua Luo, Julie Buring, I. Min Lee, Wong Ho Chow, Lee E. Moore, Christopher Wood, Timothy Eisen, Marc Henrion, James Larkin, Poulami Barman, Bradley C. Leibovich, Toni K. Choueiri, G. Mark Lathrop, Nathaniel Rothman, Jean Francois Deleuze, James D. McKay, Alexander S. Parker, Xifeng Wu, Richard S. Houlston, Paul Brennan, Stephen J. Chanock

International Agency for Research on Cancer
National Institutes of Health
St. Jude Children Research Hospital
Mayo Clinic Rochester, MN
University of Texas MD Anderson Cancer Center
Commissariat à l’énergie atomique et aux énergies alternatives
Centre d'Etude du Polymorphisme Humain (CEPH)
Russian Academy of Sciences
Kurchatov Scientific Center
University of Belgrade
Masaryk Memorial Cancer Institute
Charles University
Palacký University Olomouc
National Institute of Public Health
Russian Academy of Medical Sciences - N.N. Blokhin Russian Cancer Research Center
Carol Davila University of Medicine and Pharmacy
Pomeranian Medical University in Szczecin
Regional Authority of Public Health in Banska Bystrica
Maria Sklodowska-Curie Institute of Oncology
National Direct. of Environmental Health
Nofer Institute of Occupational Medicine
Université Paris Cité
Paris-Hôpital Tenon
Sorbonne Université
Université Paris-Saclay
German Institute of Human Nutrition Potsdam-Rehbruecke
University of Cambridge
University of Tromsø – The Arctic University of Norway
Cancer Registry of Norway Institute of Population-Based Cancer Research
Karolinska Institutet
Folkhalsan
Umeå University
Cancer Council Victoria
Queensland Institute of Medical Research
University of Queensland
University of Melbourne
Human Genetics Foundation (HuGeF)
Royal Melbourne Hospital
Norwegian University of Science and Technology
London School of Hygiene and Tropical Medicine
University of Leeds
National Institute for Health and Welfare
Vanderbilt University
American Cancer Society
Dana-Farber Cancer Institute
Brown University
Harvard University
Brigham and Women’s Hospital
Spectrum Health
Michigan State University
Van Andel Institute
Fred Hutchinson Cancer Research Center
Indiana University Bloomington
Cambridge University Hospitals NHS Foundation Trust
Icahn School of Medicine at Mount Sinai
Royal Marsden NHS Foundation Trust
Mayo Clinic College of Medicine and Science
McGill University
Mayo Clinic Jacksonville, FL
Institute of Cancer Research

Research output: Contribution to journal › Article › peer-review

100 Citations (Scopus)

Abstract

Previous genome-wide association studies (GWAS) have identified six risk loci for renal cell carcinoma (RCC). We conducted a meta-analysis of two new scans of 5,198 cases and 7,331 controls together with four existing scans, totalling 10,784 cases and 20,406 controls of European ancestry. Twenty-four loci were tested in an additional 3,182 cases and 6,301 controls. We confirm the six known RCC risk loci and identify seven new loci at 1p32.3 (rs4381241, P = 3.1×10-10), 3p22.1 (rs67311347, P = 2.5×10-8), 3q26.2 (rs10936602, P = 8.8×10-9), 8p21.3 (rs2241261, P = 5.8×10-9), 10q24.33-q25.1 (rs11813268, P = 3.9×10-8), 11q22.3 (rs74911261, P = 2.1×10-10) and 14q24.2 (rs4903064, P = 2.2×10-24). Expression quantitative trait analyses suggest plausible candidate genes at these regions that may contribute to RCC susceptibility.

Original language	English
Article number	15724
Journal	Nature Communications
Volume	8
DOIs	https://doi.org/10.1038/ncomms15724
Publication status	Published - 1 Jan 2017
Externally published	Yes

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10.1038/ncomms15724Licence: CC BY

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Scelo, G., Purdue, M. P., Brown, K. M., Johansson, M., Wang, Z., Eckel-Passow, J. E., Ye, Y., Hofmann, J. N., Choi, J., Foll, M., Gaborieau, V., Machiela, M. J., Colli, L. M., Li, P., Sampson, J. N., Abedi-Ardekani, B., Besse, C., Blanche, H., Boland, A., ... Chanock, S. J. (2017). Genome-wide association study identifies multiple risk loci for renal cell carcinoma. Nature Communications, 8, Article 15724. https://doi.org/10.1038/ncomms15724

@article{af06bc45520f464c8c2d5f51af0dad0a,

title = "Genome-wide association study identifies multiple risk loci for renal cell carcinoma",

abstract = "Previous genome-wide association studies (GWAS) have identified six risk loci for renal cell carcinoma (RCC). We conducted a meta-analysis of two new scans of 5,198 cases and 7,331 controls together with four existing scans, totalling 10,784 cases and 20,406 controls of European ancestry. Twenty-four loci were tested in an additional 3,182 cases and 6,301 controls. We confirm the six known RCC risk loci and identify seven new loci at 1p32.3 (rs4381241, P = 3.1×10-10), 3p22.1 (rs67311347, P = 2.5×10-8), 3q26.2 (rs10936602, P = 8.8×10-9), 8p21.3 (rs2241261, P = 5.8×10-9), 10q24.33-q25.1 (rs11813268, P = 3.9×10-8), 11q22.3 (rs74911261, P = 2.1×10-10) and 14q24.2 (rs4903064, P = 2.2×10-24). Expression quantitative trait analyses suggest plausible candidate genes at these regions that may contribute to RCC susceptibility.",

author = "Ghislaine Scelo and Purdue, \{Mark P.\} and Brown, \{Kevin M.\} and Mattias Johansson and Zhaoming Wang and Eckel-Passow, \{Jeanette E.\} and Yuanqing Ye and Hofmann, \{Jonathan N.\} and Jiyeon Choi and Matthieu Foll and Valerie Gaborieau and Machiela, \{Mitchell J.\} and Colli, \{Leandro M.\} and Peng Li and Sampson, \{Joshua N.\} and Behnoush Abedi-Ardekani and Celine Besse and Helene Blanche and Anne Boland and Laurie Burdette and Amelie Chabrier and Geoffroy Durand and \{Le Calvez-Kelm\}, Florence and Egor Prokhortchouk and Nivonirina Robinot and Skryabin, \{Konstantin G.\} and Wozniak, \{Magdalena B.\} and Meredith Yeager and Gordana Basta-Jovanovic and Zoran Dzamic and Lenka Foretova and Ivana Holcatova and Vladimir Janout and Dana Mates and Anush Mukeriya and Stefan Rascu and David Zaridze and Vladimir Bencko and Cezary Cybulski and Eleonora Fabianova and Viorel Jinga and Jolanta Lissowska and Jan Lubinski and Marie Navratilova and Peter Rudnai and Neonila Szeszenia-Dabrowska and Simone Benhamou and Geraldine Cancel-Tassin and Olivier Cussenot and Laura Baglietto and Heiner Boeing and Khaw, \{Kay Tee\} and Elisabete Weiderpass and Borje Ljungberg and Sitaram, \{Raviprakash T.\} and Fiona Bruinsma and Jordan, \{Susan J.\} and Gianluca Severi and Ingrid Winship and Kristian Hveem and Vatten, \{Lars J.\} and Tony Fletcher and Kvetoslava Koppova and Larsson, \{Susanna C.\} and Alicja Wolk and Banks, \{Rosamonde E.\} and Selby, \{Peter J.\} and Easton, \{Douglas F.\} and Paul Pharoah and Gabriella Andreotti and Freeman, \{Laura E.Beane\} and Stella Koutros and Demetrius Albanes and Satu M{\"a}nnist{\"o} and Stephanie Weinstein and Clark, \{Peter E.\} and Edwards, \{Todd L.\} and Loren Lipworth and Gapstur, \{Susan M.\} and Stevens, \{Victoria L.\} and Hallie Carol and Freedman, \{Matthew L.\} and Pomerantz, \{Mark M.\} and Eunyoung Cho and Peter Kraft and Preston, \{Mark A.\} and Wilson, \{Kathryn M.\} and Gaziano, \{J. Michael\} and Sesso, \{Howard D.\} and Amanda Black and Freedman, \{Neal D.\} and Huang, \{Wen Yi\} and Anema, \{John G.\} and Kahnoski, \{Richard J.\} and Lane, \{Brian R.\} and Noyes, \{Sabrina L.\} and David Petillo and Teh, \{Bin Tean\} and Ulrike Peters and Emily White and Anderson, \{Garnet L.\} and Lisa Johnson and Juhua Luo and Julie Buring and Lee, \{I. Min\} and Chow, \{Wong Ho\} and Moore, \{Lee E.\} and Christopher Wood and Timothy Eisen and Marc Henrion and James Larkin and Poulami Barman and Leibovich, \{Bradley C.\} and Choueiri, \{Toni K.\} and Lathrop, \{G. Mark\} and Nathaniel Rothman and Deleuze, \{Jean Francois\} and McKay, \{James D.\} and Parker, \{Alexander S.\} and Xifeng Wu and Houlston, \{Richard S.\} and Paul Brennan and Chanock, \{Stephen J.\}",

year = "2017",

month = jan,

day = "1",

doi = "10.1038/ncomms15724",

language = "English",

volume = "8",

journal = "Nature Communications",

issn = "2041-1723",

publisher = "Nature Research",

}

Scelo, G, Purdue, MP, Brown, KM, Johansson, M, Wang, Z, Eckel-Passow, JE, Ye, Y, Hofmann, JN, Choi, J, Foll, M, Gaborieau, V, Machiela, MJ, Colli, LM, Li, P, Sampson, JN, Abedi-Ardekani, B, Besse, C, Blanche, H, Boland, A, Burdette, L, Chabrier, A, Durand, G, Le Calvez-Kelm, F, Prokhortchouk, E, Robinot, N, Skryabin, KG, Wozniak, MB, Yeager, M, Basta-Jovanovic, G, Dzamic, Z, Foretova, L, Holcatova, I, Janout, V, Mates, D, Mukeriya, A, Rascu, S, Zaridze, D, Bencko, V, Cybulski, C, Fabianova, E, Jinga, V, Lissowska, J, Lubinski, J, Navratilova, M, Rudnai, P, Szeszenia-Dabrowska, N, Benhamou, S, Cancel-Tassin, G, Cussenot, O, Baglietto, L, Boeing, H, Khaw, KT, Weiderpass, E, Ljungberg, B, Sitaram, RT, Bruinsma, F, Jordan, SJ, Severi, G, Winship, I, Hveem, K, Vatten, LJ, Fletcher, T, Koppova, K, Larsson, SC, Wolk, A, Banks, RE, Selby, PJ, Easton, DF, Pharoah, P, Andreotti, G, Freeman, LEB, Koutros, S, Albanes, D, Männistö, S, Weinstein, S, Clark, PE, Edwards, TL, Lipworth, L, Gapstur, SM, Stevens, VL, Carol, H, Freedman, ML, Pomerantz, MM, Cho, E, Kraft, P, Preston, MA, Wilson, KM, Gaziano, JM, Sesso, HD, Black, A, Freedman, ND, Huang, WY, Anema, JG, Kahnoski, RJ, Lane, BR, Noyes, SL, Petillo, D, Teh, BT, Peters, U, White, E, Anderson, GL, Johnson, L, Luo, J, Buring, J, Lee, IM, Chow, WH, Moore, LE, Wood, C, Eisen, T, Henrion, M, Larkin, J, Barman, P, Leibovich, BC, Choueiri, TK, Lathrop, GM, Rothman, N, Deleuze, JF, McKay, JD, Parker, AS, Wu, X, Houlston, RS, Brennan, P & Chanock, SJ 2017, 'Genome-wide association study identifies multiple risk loci for renal cell carcinoma', Nature Communications, vol. 8, 15724. https://doi.org/10.1038/ncomms15724

TY - JOUR

T1 - Genome-wide association study identifies multiple risk loci for renal cell carcinoma

AU - Scelo, Ghislaine

AU - Purdue, Mark P.

AU - Brown, Kevin M.

AU - Johansson, Mattias

AU - Wang, Zhaoming

AU - Eckel-Passow, Jeanette E.

AU - Ye, Yuanqing

AU - Hofmann, Jonathan N.

AU - Choi, Jiyeon

AU - Foll, Matthieu

AU - Gaborieau, Valerie

AU - Machiela, Mitchell J.

AU - Colli, Leandro M.

AU - Li, Peng

AU - Sampson, Joshua N.

AU - Abedi-Ardekani, Behnoush

AU - Besse, Celine

AU - Blanche, Helene

AU - Boland, Anne

AU - Burdette, Laurie

AU - Chabrier, Amelie

AU - Durand, Geoffroy

AU - Le Calvez-Kelm, Florence

AU - Prokhortchouk, Egor

AU - Robinot, Nivonirina

AU - Skryabin, Konstantin G.

AU - Wozniak, Magdalena B.

AU - Yeager, Meredith

AU - Basta-Jovanovic, Gordana

AU - Dzamic, Zoran

AU - Foretova, Lenka

AU - Holcatova, Ivana

AU - Janout, Vladimir

AU - Mates, Dana

AU - Mukeriya, Anush

AU - Rascu, Stefan

AU - Zaridze, David

AU - Bencko, Vladimir

AU - Cybulski, Cezary

AU - Fabianova, Eleonora

AU - Jinga, Viorel

AU - Lissowska, Jolanta

AU - Lubinski, Jan

AU - Navratilova, Marie

AU - Rudnai, Peter

AU - Szeszenia-Dabrowska, Neonila

AU - Benhamou, Simone

AU - Cancel-Tassin, Geraldine

AU - Cussenot, Olivier

AU - Baglietto, Laura

AU - Boeing, Heiner

AU - Khaw, Kay Tee

AU - Weiderpass, Elisabete

AU - Ljungberg, Borje

AU - Sitaram, Raviprakash T.

AU - Bruinsma, Fiona

AU - Jordan, Susan J.

AU - Severi, Gianluca

AU - Winship, Ingrid

AU - Hveem, Kristian

AU - Vatten, Lars J.

AU - Fletcher, Tony

AU - Koppova, Kvetoslava

AU - Larsson, Susanna C.

AU - Wolk, Alicja

AU - Banks, Rosamonde E.

AU - Selby, Peter J.

AU - Easton, Douglas F.

AU - Pharoah, Paul

AU - Andreotti, Gabriella

AU - Freeman, Laura E.Beane

AU - Koutros, Stella

AU - Albanes, Demetrius

AU - Männistö, Satu

AU - Weinstein, Stephanie

AU - Clark, Peter E.

AU - Edwards, Todd L.

AU - Lipworth, Loren

AU - Gapstur, Susan M.

AU - Stevens, Victoria L.

AU - Carol, Hallie

AU - Freedman, Matthew L.

AU - Pomerantz, Mark M.

AU - Cho, Eunyoung

AU - Kraft, Peter

AU - Preston, Mark A.

AU - Wilson, Kathryn M.

AU - Gaziano, J. Michael

AU - Sesso, Howard D.

AU - Black, Amanda

AU - Freedman, Neal D.

AU - Huang, Wen Yi

AU - Anema, John G.

AU - Kahnoski, Richard J.

AU - Lane, Brian R.

AU - Noyes, Sabrina L.

AU - Petillo, David

AU - Teh, Bin Tean

AU - Peters, Ulrike

AU - White, Emily

AU - Anderson, Garnet L.

AU - Johnson, Lisa

AU - Luo, Juhua

AU - Buring, Julie

AU - Lee, I. Min

AU - Chow, Wong Ho

AU - Moore, Lee E.

AU - Wood, Christopher

AU - Eisen, Timothy

AU - Henrion, Marc

AU - Larkin, James

AU - Barman, Poulami

AU - Leibovich, Bradley C.

AU - Choueiri, Toni K.

AU - Lathrop, G. Mark

AU - Rothman, Nathaniel

AU - Deleuze, Jean Francois

AU - McKay, James D.

AU - Parker, Alexander S.

AU - Wu, Xifeng

AU - Houlston, Richard S.

AU - Brennan, Paul

AU - Chanock, Stephen J.

PY - 2017/1/1

Y1 - 2017/1/1

N2 - Previous genome-wide association studies (GWAS) have identified six risk loci for renal cell carcinoma (RCC). We conducted a meta-analysis of two new scans of 5,198 cases and 7,331 controls together with four existing scans, totalling 10,784 cases and 20,406 controls of European ancestry. Twenty-four loci were tested in an additional 3,182 cases and 6,301 controls. We confirm the six known RCC risk loci and identify seven new loci at 1p32.3 (rs4381241, P = 3.1×10-10), 3p22.1 (rs67311347, P = 2.5×10-8), 3q26.2 (rs10936602, P = 8.8×10-9), 8p21.3 (rs2241261, P = 5.8×10-9), 10q24.33-q25.1 (rs11813268, P = 3.9×10-8), 11q22.3 (rs74911261, P = 2.1×10-10) and 14q24.2 (rs4903064, P = 2.2×10-24). Expression quantitative trait analyses suggest plausible candidate genes at these regions that may contribute to RCC susceptibility.

AB - Previous genome-wide association studies (GWAS) have identified six risk loci for renal cell carcinoma (RCC). We conducted a meta-analysis of two new scans of 5,198 cases and 7,331 controls together with four existing scans, totalling 10,784 cases and 20,406 controls of European ancestry. Twenty-four loci were tested in an additional 3,182 cases and 6,301 controls. We confirm the six known RCC risk loci and identify seven new loci at 1p32.3 (rs4381241, P = 3.1×10-10), 3p22.1 (rs67311347, P = 2.5×10-8), 3q26.2 (rs10936602, P = 8.8×10-9), 8p21.3 (rs2241261, P = 5.8×10-9), 10q24.33-q25.1 (rs11813268, P = 3.9×10-8), 11q22.3 (rs74911261, P = 2.1×10-10) and 14q24.2 (rs4903064, P = 2.2×10-24). Expression quantitative trait analyses suggest plausible candidate genes at these regions that may contribute to RCC susceptibility.

U2 - 10.1038/ncomms15724

DO - 10.1038/ncomms15724

M3 - Article

SN - 2041-1723

VL - 8

JO - Nature Communications

JF - Nature Communications

M1 - 15724

ER -

Genome-wide association study identifies multiple risk loci for renal cell carcinoma

Abstract

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