Genetic diversity of the African malaria vector Anopheles gambiae

Alistair Miles; Nicholas J. Harding; Giordano Bottà; Chris S. Clarkson; Tiago Antão; Krzysztof Kozak; Daniel R. Schrider; Andrew D. Kern; Seth Redmond; Igor Sharakhov; Richard D. Pearson; Christina Bergey; Michael C. Fontaine; Martin Donnelly; Mara K.N. Lawniczak; Diego Ayala; Nora J. Besansky; Austin Burt; Beniamino Caputo; Alessandra Della Torre; H. Charles J. Godfray; Matthew W. Hahn; Janet Midega; Daniel E. Neafsey; Samantha O'Loughlin; João Pinto; Michelle M. Riehle; Kenneth D. Vernick; David Weetman; Craig S. Wilding; Bradley J. White; Arlete D. Troco; Abdoulaye Diabaté; Carlo Costantini; Kyanne R. Rohatgi; Nohal Elissa; Boubacar Coulibaly; João Dinis; Charles Mbogo; Philip Bejon; Henry D. Mawejje; Jim Stalker; Kirk Rockett; Eleanor Drury; Daniel Mead; Anna Jeffreys; Christina Hubbart; Kate Rowlands; Alison T. Isaacs; Dushyanth Jyothi; Cinzia Malangone; Paul Vauterin; Ben Jeffery; Ian Wright; Lee Hart; Krzysztof Kluczyński; Victoria Cornelius; Bronwyn Macinnis; Christa Henrichs; Rachel Giacomantonio; Dominic P. Kwiatkowski

doi:10.1038/nature24995

Genetic diversity of the African malaria vector Anopheles gambiae

Alistair Miles
, Nicholas J. Harding
, Giordano Bottà
, Chris S. Clarkson
, Tiago Antão
, Krzysztof Kozak
, Daniel R. Schrider
, Andrew D. Kern
, Seth Redmond
, Igor Sharakhov
, Richard D. Pearson
, Christina Bergey
, Michael C. Fontaine
, Martin Donnelly
, Mara K.N. Lawniczak
, Diego Ayala
, Nora J. Besansky
, Austin Burt
, Beniamino Caputo
, Alessandra Della Torre

H. Charles J. Godfray, Matthew W. Hahn, Janet Midega, Daniel E. Neafsey, Samantha O'Loughlin, João Pinto, Michelle M. Riehle, Kenneth D. Vernick, David Weetman, Craig S. Wilding, Bradley J. White, Arlete D. Troco, Abdoulaye Diabaté, Carlo Costantini, Kyanne R. Rohatgi, Nohal Elissa, Boubacar Coulibaly, João Dinis, Charles Mbogo, Philip Bejon, Henry D. Mawejje, Jim Stalker, Kirk Rockett, Eleanor Drury, Daniel Mead, Anna Jeffreys, Christina Hubbart, Kate Rowlands, Alison T. Isaacs, Dushyanth Jyothi, Cinzia Malangone, Paul Vauterin, Ben Jeffery, Ian Wright, Lee Hart, Krzysztof Kluczyński, Victoria Cornelius, Bronwyn Macinnis, Christa Henrichs, Rachel Giacomantonio, Dominic P. Kwiatkowski

Vector Biology

Wellcome Sanger Institute
University of Oxford
University of Rome La Sapienza
Liverpool School of Tropical Medicine
University of Montana
Rutgers - The State University of New Jersey, New Brunswick
Broad Institute
Virginia Polytechnic Institute and State University
Tomsk State University
University of Notre Dame
Groningen Institute for Evolutionary Life Sciences (GELIFES)
Centre international de recherches médicales de Franceville
Université Montpellier
Imperial College London
Indiana University Bloomington
Wellcome Trust Research Laboratories Nairobi
NOVA University Lisbon
University of Minnesota Twin Cities
Institut Pasteur Paris
Liverpool John Moores University
University of California at Riverside
Ministério da Saúde
Institut de Recherche en Sciences de la Santé (IRSS)
Organisation de Coordination pour la lutte contre les Endémies en Afrique Centrale
Université de Bamako
Instituto Nacional de Saúde Pública
Infectious Diseases Research Collaboration

Research output: Contribution to journal › Article › peer-review

284 Citations (Scopus)

Abstract

The sustainability of malaria control in Africa is threatened by the rise of insecticide resistance in Anopheles mosquitoes, which transmit the disease1. To gain a deeper understanding of how mosquito populations are evolving, here we sequenced the genomes of 765 specimens of Anopheles gambiae and Anopheles coluzzii sampled from 15 locations across Africa, and identified over 50 million single nucleotide polymorphisms within the accessible genome. These data revealed complex population structure and patterns of gene flow, with evidence of ancient expansions, recent bottlenecks, and local variation in effective population size. Strong signals of recent selection were observed in insecticide-resistance genes, with several sweeps spreading over large geographical distances and between species. The design of new tools for mosquito control using gene-drive systems will need to take account of high levels of genetic diversity in natural mosquito populations.

Original language	English
Pages (from-to)	96-100
Number of pages	5
Journal	Nature
Volume	552
Early online date	29 Nov 2017
DOIs	https://doi.org/10.1038/nature24995
Publication status	Published - 7 Dec 2017

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

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Genetic diversity Accepted author manuscript, 2.55 MB

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Miles, A., Harding, N. J., Bottà, G., Clarkson, C. S., Antão, T., Kozak, K., Schrider, D. R., Kern, A. D., Redmond, S., Sharakhov, I., Pearson, R. D., Bergey, C., Fontaine, M. C., Donnelly, M., Lawniczak, M. K. N., Ayala, D., Besansky, N. J., Burt, A., Caputo, B., ... Kwiatkowski, D. P. (2017). Genetic diversity of the African malaria vector Anopheles gambiae. Nature, 552, 96-100. https://doi.org/10.1038/nature24995

@article{716e5e7d02614d9fba8de80554c8b89b,

title = "Genetic diversity of the African malaria vector Anopheles gambiae",

abstract = "The sustainability of malaria control in Africa is threatened by the rise of insecticide resistance in Anopheles mosquitoes, which transmit the disease1. To gain a deeper understanding of how mosquito populations are evolving, here we sequenced the genomes of 765 specimens of Anopheles gambiae and Anopheles coluzzii sampled from 15 locations across Africa, and identified over 50 million single nucleotide polymorphisms within the accessible genome. These data revealed complex population structure and patterns of gene flow, with evidence of ancient expansions, recent bottlenecks, and local variation in effective population size. Strong signals of recent selection were observed in insecticide-resistance genes, with several sweeps spreading over large geographical distances and between species. The design of new tools for mosquito control using gene-drive systems will need to take account of high levels of genetic diversity in natural mosquito populations.",

author = "Alistair Miles and Harding, \{Nicholas J.\} and Giordano Bott{\`a} and Clarkson, \{Chris S.\} and Tiago Ant{\~a}o and Krzysztof Kozak and Schrider, \{Daniel R.\} and Kern, \{Andrew D.\} and Seth Redmond and Igor Sharakhov and Pearson, \{Richard D.\} and Christina Bergey and Fontaine, \{Michael C.\} and Martin Donnelly and Lawniczak, \{Mara K.N.\} and Diego Ayala and Besansky, \{Nora J.\} and Austin Burt and Beniamino Caputo and Torre, \{Alessandra Della\} and Godfray, \{H. Charles J.\} and Hahn, \{Matthew W.\} and Janet Midega and Neafsey, \{Daniel E.\} and Samantha O'Loughlin and Jo{\~a}o Pinto and Riehle, \{Michelle M.\} and Vernick, \{Kenneth D.\} and David Weetman and Wilding, \{Craig S.\} and White, \{Bradley J.\} and Troco, \{Arlete D.\} and Abdoulaye Diabat{\'e} and Carlo Costantini and Rohatgi, \{Kyanne R.\} and Nohal Elissa and Boubacar Coulibaly and Jo{\~a}o Dinis and Charles Mbogo and Philip Bejon and Mawejje, \{Henry D.\} and Jim Stalker and Kirk Rockett and Eleanor Drury and Daniel Mead and Anna Jeffreys and Christina Hubbart and Kate Rowlands and Isaacs, \{Alison T.\} and Dushyanth Jyothi and Cinzia Malangone and Paul Vauterin and Ben Jeffery and Ian Wright and Lee Hart and Krzysztof Kluczy{\'n}ski and Victoria Cornelius and Bronwyn Macinnis and Christa Henrichs and Rachel Giacomantonio and Kwiatkowski, \{Dominic P.\}",

year = "2017",

month = dec,

day = "7",

doi = "10.1038/nature24995",

language = "English",

volume = "552",

pages = "96--100",

journal = "Nature",

issn = "0028-0836",

publisher = "Nature Research",

}

Miles, A, Harding, NJ, Bottà, G, Clarkson, CS, Antão, T, Kozak, K, Schrider, DR, Kern, AD, Redmond, S, Sharakhov, I, Pearson, RD, Bergey, C, Fontaine, MC, Donnelly, M, Lawniczak, MKN, Ayala, D, Besansky, NJ, Burt, A, Caputo, B, Torre, AD, Godfray, HCJ, Hahn, MW, Midega, J, Neafsey, DE, O'Loughlin, S, Pinto, J, Riehle, MM, Vernick, KD, Weetman, D, Wilding, CS, White, BJ, Troco, AD, Diabaté, A, Costantini, C, Rohatgi, KR, Elissa, N, Coulibaly, B, Dinis, J, Mbogo, C, Bejon, P, Mawejje, HD, Stalker, J, Rockett, K, Drury, E, Mead, D, Jeffreys, A, Hubbart, C, Rowlands, K, Isaacs, AT, Jyothi, D, Malangone, C, Vauterin, P, Jeffery, B, Wright, I, Hart, L, Kluczyński, K, Cornelius, V, Macinnis, B, Henrichs, C, Giacomantonio, R & Kwiatkowski, DP 2017, 'Genetic diversity of the African malaria vector Anopheles gambiae', Nature, vol. 552, pp. 96-100. https://doi.org/10.1038/nature24995

TY - JOUR

T1 - Genetic diversity of the African malaria vector Anopheles gambiae

AU - Miles, Alistair

AU - Harding, Nicholas J.

AU - Bottà, Giordano

AU - Clarkson, Chris S.

AU - Antão, Tiago

AU - Kozak, Krzysztof

AU - Schrider, Daniel R.

AU - Kern, Andrew D.

AU - Redmond, Seth

AU - Sharakhov, Igor

AU - Pearson, Richard D.

AU - Bergey, Christina

AU - Fontaine, Michael C.

AU - Donnelly, Martin

AU - Lawniczak, Mara K.N.

AU - Ayala, Diego

AU - Besansky, Nora J.

AU - Burt, Austin

AU - Caputo, Beniamino

AU - Torre, Alessandra Della

AU - Godfray, H. Charles J.

AU - Hahn, Matthew W.

AU - Midega, Janet

AU - Neafsey, Daniel E.

AU - O'Loughlin, Samantha

AU - Pinto, João

AU - Riehle, Michelle M.

AU - Vernick, Kenneth D.

AU - Weetman, David

AU - Wilding, Craig S.

AU - White, Bradley J.

AU - Troco, Arlete D.

AU - Diabaté, Abdoulaye

AU - Costantini, Carlo

AU - Rohatgi, Kyanne R.

AU - Elissa, Nohal

AU - Coulibaly, Boubacar

AU - Dinis, João

AU - Mbogo, Charles

AU - Bejon, Philip

AU - Mawejje, Henry D.

AU - Stalker, Jim

AU - Rockett, Kirk

AU - Drury, Eleanor

AU - Mead, Daniel

AU - Jeffreys, Anna

AU - Hubbart, Christina

AU - Rowlands, Kate

AU - Isaacs, Alison T.

AU - Jyothi, Dushyanth

AU - Malangone, Cinzia

AU - Vauterin, Paul

AU - Jeffery, Ben

AU - Wright, Ian

AU - Hart, Lee

AU - Kluczyński, Krzysztof

AU - Cornelius, Victoria

AU - Macinnis, Bronwyn

AU - Henrichs, Christa

AU - Giacomantonio, Rachel

AU - Kwiatkowski, Dominic P.

PY - 2017/12/7

Y1 - 2017/12/7

N2 - The sustainability of malaria control in Africa is threatened by the rise of insecticide resistance in Anopheles mosquitoes, which transmit the disease1. To gain a deeper understanding of how mosquito populations are evolving, here we sequenced the genomes of 765 specimens of Anopheles gambiae and Anopheles coluzzii sampled from 15 locations across Africa, and identified over 50 million single nucleotide polymorphisms within the accessible genome. These data revealed complex population structure and patterns of gene flow, with evidence of ancient expansions, recent bottlenecks, and local variation in effective population size. Strong signals of recent selection were observed in insecticide-resistance genes, with several sweeps spreading over large geographical distances and between species. The design of new tools for mosquito control using gene-drive systems will need to take account of high levels of genetic diversity in natural mosquito populations.

AB - The sustainability of malaria control in Africa is threatened by the rise of insecticide resistance in Anopheles mosquitoes, which transmit the disease1. To gain a deeper understanding of how mosquito populations are evolving, here we sequenced the genomes of 765 specimens of Anopheles gambiae and Anopheles coluzzii sampled from 15 locations across Africa, and identified over 50 million single nucleotide polymorphisms within the accessible genome. These data revealed complex population structure and patterns of gene flow, with evidence of ancient expansions, recent bottlenecks, and local variation in effective population size. Strong signals of recent selection were observed in insecticide-resistance genes, with several sweeps spreading over large geographical distances and between species. The design of new tools for mosquito control using gene-drive systems will need to take account of high levels of genetic diversity in natural mosquito populations.

U2 - 10.1038/nature24995

DO - 10.1038/nature24995

M3 - Article

SN - 0028-0836

VL - 552

SP - 96

EP - 100

JO - Nature

JF - Nature

ER -

Genetic diversity of the African malaria vector Anopheles gambiae

Abstract

UN SDGs

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