Gastrointestinal nematode infection is associated with variation in innate immune responsiveness

Joseph A. Jackson; Joseph Turner; Mahine Kamal; Victoria Wright; Quentin Bickle; Kathryn J. Else; Mahdi Ramsan; Janette E. Bradley

doi:10.1016/j.micinf.2005.07.025

Gastrointestinal nematode infection is associated with variation in innate immune responsiveness

Joseph A. Jackson, Joseph Turner, Mahine Kamal, Victoria Wright, Quentin Bickle, Kathryn J. Else, Mahdi Ramsan, Janette E. Bradley

Tropical Disease Biology

Research output: Contribution to journal › Article › peer-review

29 Citations (Scopus)

Abstract

Ex vivo monocyte cytokine responses (IL-1 beta, TNF-alpha, IL-12p70, IL-10, TGF-beta) to bacterial TLR2 and TLR4 ligands were quantified in 47 gastrointestinal (GI) nematode-ex posed children in Pemba Island, Tanzania. Worminess (estimated by faecal egg counts (FEC)) had a positive relationship with pro-inflammatory TNF-a and IL-10 responsiveness to the TLR ligands. In particular, there was a strong significant relationship with TNF-alpha response to TLR4 ligand (LPS). There were no significant associations between regulatory responses (IL-10,TGF-beta) and worminess. These results are consistent with the possibility that GI nematodes modulate innate responses and may indicate a potential mechanism for interactions between GI nematodiasis and important bystander pathogens. (c) 2005 Elsevier SAS. All rights reserved.

Original language	English
Pages (from-to)	487-492
Number of pages	6
Journal	Microbes and Infection
Volume	8
Issue number	2
DOIs	https://doi.org/10.1016/j.micinf.2005.07.025
Publication status	Published - 1 Feb 2006

Keywords

Human
IL-10
Innate immunity
Monocyte
Nematodiasis
TGF-β
tlr2
tlr4
TNF-α

Access to Document

10.1016/j.micinf.2005.07.025

Cite this

@article{919f27df0eca4e74a186084ce4129b01,

title = "Gastrointestinal nematode infection is associated with variation in innate immune responsiveness",

abstract = "Ex vivo monocyte cytokine responses (IL-1 beta, TNF-alpha, IL-12p70, IL-10, TGF-beta) to bacterial TLR2 and TLR4 ligands were quantified in 47 gastrointestinal (GI) nematode-ex posed children in Pemba Island, Tanzania. Worminess (estimated by faecal egg counts (FEC)) had a positive relationship with pro-inflammatory TNF-a and IL-10 responsiveness to the TLR ligands. In particular, there was a strong significant relationship with TNF-alpha response to TLR4 ligand (LPS). There were no significant associations between regulatory responses (IL-10,TGF-beta) and worminess. These results are consistent with the possibility that GI nematodes modulate innate responses and may indicate a potential mechanism for interactions between GI nematodiasis and important bystander pathogens. (c) 2005 Elsevier SAS. All rights reserved.",

keywords = "Human, IL-10, Innate immunity, Monocyte, Nematodiasis, TGF-β, tlr2, tlr4, TNF-α",

author = "Jackson, \{Joseph A.\} and Joseph Turner and Mahine Kamal and Victoria Wright and Quentin Bickle and Else, \{Kathryn J.\} and Mahdi Ramsan and Bradley, \{Janette E.\}",

year = "2006",

month = feb,

day = "1",

doi = "10.1016/j.micinf.2005.07.025",

language = "English",

volume = "8",

pages = "487--492",

journal = "Microbes and Infection",

issn = "1286-4579",

publisher = "Elsevier Masson s.r.l.",

number = "2",

}

TY - JOUR

T1 - Gastrointestinal nematode infection is associated with variation in innate immune responsiveness

AU - Jackson, Joseph A.

AU - Turner, Joseph

AU - Kamal, Mahine

AU - Wright, Victoria

AU - Bickle, Quentin

AU - Else, Kathryn J.

AU - Ramsan, Mahdi

AU - Bradley, Janette E.

PY - 2006/2/1

Y1 - 2006/2/1

N2 - Ex vivo monocyte cytokine responses (IL-1 beta, TNF-alpha, IL-12p70, IL-10, TGF-beta) to bacterial TLR2 and TLR4 ligands were quantified in 47 gastrointestinal (GI) nematode-ex posed children in Pemba Island, Tanzania. Worminess (estimated by faecal egg counts (FEC)) had a positive relationship with pro-inflammatory TNF-a and IL-10 responsiveness to the TLR ligands. In particular, there was a strong significant relationship with TNF-alpha response to TLR4 ligand (LPS). There were no significant associations between regulatory responses (IL-10,TGF-beta) and worminess. These results are consistent with the possibility that GI nematodes modulate innate responses and may indicate a potential mechanism for interactions between GI nematodiasis and important bystander pathogens. (c) 2005 Elsevier SAS. All rights reserved.

AB - Ex vivo monocyte cytokine responses (IL-1 beta, TNF-alpha, IL-12p70, IL-10, TGF-beta) to bacterial TLR2 and TLR4 ligands were quantified in 47 gastrointestinal (GI) nematode-ex posed children in Pemba Island, Tanzania. Worminess (estimated by faecal egg counts (FEC)) had a positive relationship with pro-inflammatory TNF-a and IL-10 responsiveness to the TLR ligands. In particular, there was a strong significant relationship with TNF-alpha response to TLR4 ligand (LPS). There were no significant associations between regulatory responses (IL-10,TGF-beta) and worminess. These results are consistent with the possibility that GI nematodes modulate innate responses and may indicate a potential mechanism for interactions between GI nematodiasis and important bystander pathogens. (c) 2005 Elsevier SAS. All rights reserved.

KW - Human

KW - IL-10

KW - Innate immunity

KW - Monocyte

KW - Nematodiasis

KW - TGF-β

KW - tlr2

KW - tlr4

KW - TNF-α

U2 - 10.1016/j.micinf.2005.07.025

DO - 10.1016/j.micinf.2005.07.025

M3 - Article

SN - 1286-4579

VL - 8

SP - 487

EP - 492

JO - Microbes and Infection

JF - Microbes and Infection

IS - 2

ER -

Gastrointestinal nematode infection is associated with variation in innate immune responsiveness

Abstract

Keywords

Access to Document

Fingerprint

Cite this