Gastrointestinal nematode infection is associated with variation in innate immune responsiveness

Joseph A. Jackson; Joseph Turner; Mahine Kamal; Victoria Wright; Quentin Bickle; Kathryn J. Else; Mahdi Ramsan; Janette E. Bradley

doi:10.1016/j.micinf.2005.07.025

Gastrointestinal nematode infection is associated with variation in innate immune responsiveness

Joseph A. Jackson
, Joseph Turner
, Mahine Kamal
, Victoria Wright
, Quentin Bickle
, Kathryn J. Else
, Mahdi Ramsan
, Janette E. Bradley

Tropical Disease Biology

Research output: Contribution to journal › Article › peer-review

29 Citations (Scopus)

Abstract

Ex vivo monocyte cytokine responses (IL-1 beta, TNF-alpha, IL-12p70, IL-10, TGF-beta) to bacterial TLR2 and TLR4 ligands were quantified in 47 gastrointestinal (GI) nematode-ex posed children in Pemba Island, Tanzania. Worminess (estimated by faecal egg counts (FEC)) had a positive relationship with pro-inflammatory TNF-a and IL-10 responsiveness to the TLR ligands. In particular, there was a strong significant relationship with TNF-alpha response to TLR4 ligand (LPS). There were no significant associations between regulatory responses (IL-10,TGF-beta) and worminess. These results are consistent with the possibility that GI nematodes modulate innate responses and may indicate a potential mechanism for interactions between GI nematodiasis and important bystander pathogens. (c) 2005 Elsevier SAS. All rights reserved.

Original language	English
Pages (from-to)	487-492
Number of pages	6
Journal	Microbes and Infection
Volume	8
Issue number	2
DOIs	https://doi.org/10.1016/j.micinf.2005.07.025
Publication status	Published - 1 Feb 2006

Keywords

Human
IL-10
Innate immunity
Monocyte
Nematodiasis
TGF-β
tlr2
tlr4
TNF-α

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10.1016/j.micinf.2005.07.025

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title = "Gastrointestinal nematode infection is associated with variation in innate immune responsiveness",

abstract = "Ex vivo monocyte cytokine responses (IL-1 beta, TNF-alpha, IL-12p70, IL-10, TGF-beta) to bacterial TLR2 and TLR4 ligands were quantified in 47 gastrointestinal (GI) nematode-ex posed children in Pemba Island, Tanzania. Worminess (estimated by faecal egg counts (FEC)) had a positive relationship with pro-inflammatory TNF-a and IL-10 responsiveness to the TLR ligands. In particular, there was a strong significant relationship with TNF-alpha response to TLR4 ligand (LPS). There were no significant associations between regulatory responses (IL-10,TGF-beta) and worminess. These results are consistent with the possibility that GI nematodes modulate innate responses and may indicate a potential mechanism for interactions between GI nematodiasis and important bystander pathogens. (c) 2005 Elsevier SAS. All rights reserved.",

keywords = "Human, IL-10, Innate immunity, Monocyte, Nematodiasis, TGF-β, tlr2, tlr4, TNF-α",

author = "Jackson, \{Joseph A.\} and Joseph Turner and Mahine Kamal and Victoria Wright and Quentin Bickle and Else, \{Kathryn J.\} and Mahdi Ramsan and Bradley, \{Janette E.\}",

year = "2006",

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doi = "10.1016/j.micinf.2005.07.025",

language = "English",

volume = "8",

pages = "487--492",

journal = "Microbes and Infection",

issn = "1286-4579",

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TY - JOUR

T1 - Gastrointestinal nematode infection is associated with variation in innate immune responsiveness

AU - Jackson, Joseph A.

AU - Turner, Joseph

AU - Kamal, Mahine

AU - Wright, Victoria

AU - Bickle, Quentin

AU - Else, Kathryn J.

AU - Ramsan, Mahdi

AU - Bradley, Janette E.

PY - 2006/2/1

Y1 - 2006/2/1

N2 - Ex vivo monocyte cytokine responses (IL-1 beta, TNF-alpha, IL-12p70, IL-10, TGF-beta) to bacterial TLR2 and TLR4 ligands were quantified in 47 gastrointestinal (GI) nematode-ex posed children in Pemba Island, Tanzania. Worminess (estimated by faecal egg counts (FEC)) had a positive relationship with pro-inflammatory TNF-a and IL-10 responsiveness to the TLR ligands. In particular, there was a strong significant relationship with TNF-alpha response to TLR4 ligand (LPS). There were no significant associations between regulatory responses (IL-10,TGF-beta) and worminess. These results are consistent with the possibility that GI nematodes modulate innate responses and may indicate a potential mechanism for interactions between GI nematodiasis and important bystander pathogens. (c) 2005 Elsevier SAS. All rights reserved.

AB - Ex vivo monocyte cytokine responses (IL-1 beta, TNF-alpha, IL-12p70, IL-10, TGF-beta) to bacterial TLR2 and TLR4 ligands were quantified in 47 gastrointestinal (GI) nematode-ex posed children in Pemba Island, Tanzania. Worminess (estimated by faecal egg counts (FEC)) had a positive relationship with pro-inflammatory TNF-a and IL-10 responsiveness to the TLR ligands. In particular, there was a strong significant relationship with TNF-alpha response to TLR4 ligand (LPS). There were no significant associations between regulatory responses (IL-10,TGF-beta) and worminess. These results are consistent with the possibility that GI nematodes modulate innate responses and may indicate a potential mechanism for interactions between GI nematodiasis and important bystander pathogens. (c) 2005 Elsevier SAS. All rights reserved.

KW - Human

KW - IL-10

KW - Innate immunity

KW - Monocyte

KW - Nematodiasis

KW - TGF-β

KW - tlr2

KW - tlr4

KW - TNF-α

U2 - 10.1016/j.micinf.2005.07.025

DO - 10.1016/j.micinf.2005.07.025

M3 - Article

SN - 1286-4579

VL - 8

SP - 487

EP - 492

JO - Microbes and Infection

JF - Microbes and Infection

IS - 2

ER -

Gastrointestinal nematode infection is associated with variation in innate immune responsiveness

Abstract

Keywords

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