Gametocytocidal drugs: taking the population perspective.

Patricia Graves; Hellen Gelband; Paul Garner; Leslie Choi

doi:10.1016/s1473-3099(18)30337-2

Gametocytocidal drugs: taking the population perspective.

Patricia Graves, Hellen Gelband, Paul Garner, Leslie Choi

Liverpool School of Tropical Medicine

Research output: Contribution to journal › Letter › peer-review

2 Citations (Scopus)

Abstract

In their Article Dicko and colleagues1 state that both primaquine and methylene blue were “highly efficacious for preventing Plasmodium falciparum transmission” when given alongside primary malaria treatment, implying an effect on malaria transmission in the community. However, the trial measured the infectiousness of individuals to mosquitoes, which is several steps removed from the dynamics of disease transmission. Other trials have also measured whether individuals are less infectious to mosquitoes after treatment with a gametocytocidal agent, but none have measured an effect on transmission in the community, the outcome of real interest.

Original language	English
Pages (from-to)	719
Number of pages	1
Journal	The Lancet Infectious Diseases
Volume	18
Issue number	7
DOIs	https://doi.org/10.1016/s1473-3099(18)30337-2
Publication status	Published - 1 Jul 2018

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10.1016/s1473-3099(18)30337-2

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abstract = "In their Article Dicko and colleagues1 state that both primaquine and methylene blue were “highly efficacious for preventing Plasmodium falciparum transmission” when given alongside primary malaria treatment, implying an effect on malaria transmission in the community. However, the trial measured the infectiousness of individuals to mosquitoes, which is several steps removed from the dynamics of disease transmission. Other trials have also measured whether individuals are less infectious to mosquitoes after treatment with a gametocytocidal agent, but none have measured an effect on transmission in the community, the outcome of real interest.",

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N2 - In their Article Dicko and colleagues1 state that both primaquine and methylene blue were “highly efficacious for preventing Plasmodium falciparum transmission” when given alongside primary malaria treatment, implying an effect on malaria transmission in the community. However, the trial measured the infectiousness of individuals to mosquitoes, which is several steps removed from the dynamics of disease transmission. Other trials have also measured whether individuals are less infectious to mosquitoes after treatment with a gametocytocidal agent, but none have measured an effect on transmission in the community, the outcome of real interest.

AB - In their Article Dicko and colleagues1 state that both primaquine and methylene blue were “highly efficacious for preventing Plasmodium falciparum transmission” when given alongside primary malaria treatment, implying an effect on malaria transmission in the community. However, the trial measured the infectiousness of individuals to mosquitoes, which is several steps removed from the dynamics of disease transmission. Other trials have also measured whether individuals are less infectious to mosquitoes after treatment with a gametocytocidal agent, but none have measured an effect on transmission in the community, the outcome of real interest.

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DO - 10.1016/s1473-3099(18)30337-2

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ER -

Gametocytocidal drugs: taking the population perspective.

Abstract

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