Fungal Burden and Raised Intracranial Pressure Are Independently Associated With Visual Loss in Human Immunodeficiency Virus-Associated Cryptococcal Meningitis

Síle F. Molloy; Brad Ross; Cecilia Kanyama; Sayoki Mfinanga; Sokoine Lesikari; Robert S. Heyderman; Newton Kalata; Jayne Ellis; Charles Kouanfack; Duncan Chanda; Elvis Temfack; Shabir Lakhi; Anand Moodley; Adrienne K. Chan; Joep J. Van Oosterhout; Yacouba Mapoure; Peter Mwaba; David Lalloo; Duolao Wang; Olivier Lortholary; Shabbar Jaffar; Mina C. Hosseinipour; Angela Loyse; Thomas S. Harrison; Tihana Bicanic

doi:10.1093/ofid/ofab066

Fungal Burden and Raised Intracranial Pressure Are Independently Associated With Visual Loss in Human Immunodeficiency Virus-Associated Cryptococcal Meningitis

Síle F. Molloy
, Brad Ross
, Cecilia Kanyama
, Sayoki Mfinanga
, Sokoine Lesikari
, Robert S. Heyderman
, Newton Kalata
, Jayne Ellis
, Charles Kouanfack
, Duncan Chanda
, Elvis Temfack
, Shabir Lakhi
, Anand Moodley
, Adrienne K. Chan
, Joep J. Van Oosterhout
, Yacouba Mapoure
, Peter Mwaba
, David Lalloo
, Duolao Wang
, Olivier Lortholary

Shabbar Jaffar, Mina C. Hosseinipour, Angela Loyse, Thomas S. Harrison, Tihana Bicanic

City St George's, University of London
St George's University Hospitals NHS Foundation Trust
Kamuzu Central Hospital
National Institute for Medical Research Tanzania
Liverpool School of Tropical Medicine
University College London
Malawi-Liverpool-Wellcome Trust Clinical Research Programme
Queen Elizabeth Central Hospital Malawi
Hospital for Tropical Diseases
Central Hospital of Yaoundé
University Teaching Hospital Lusaka
Hôpital Général de Douala
National Public Health Laboratory
University of The Free State
Ministry of Health, Malawi
University of Toronto
Partners in Hope Medical Center
University of California at Los Angeles
Lusaka Apex Medical University
Centre national de la Recherche Scientifique
Université Paris Cité
University of North Carolina at Chapel Hill

Research output: Contribution to journal › Article › peer-review

9 Citations (Scopus)

Abstract

Among 472 patients with human immunodeficiency virus-associated cryptococcal meningitis, 16% had severe visual loss at presentation, and 46% of these were 4-week survivors and remained severely impaired. Baseline cerebrospinal fluid opening pressure ≥40 cmH2O (adjusted odds ratio [aOR], 2.56; 95% confidence interval [CI], 1.36–4.83; P = .02) and fungal burden >6.0 log10 colonies/mL (aOR, 3.01; 95% CI, 1.58–5.7; P = .003) were independently associated with severe visual loss.

Original language	English
Pages (from-to)	ofab066
Journal	Open Forum Infectious Diseases
Volume	8
Issue number	4
Early online date	5 Feb 2021
DOIs	https://doi.org/10.1093/ofid/ofab066
Publication status	Published - 1 Apr 2021

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

cryptococcal meningitis
fungal burden
HIV
raised intracranial pressure
visual loss

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10.1093/ofid/ofab066Licence: CC BY

VA paper OFID Revised cleanAccepted author manuscript, 265 KBLicence: CC BY

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Molloy, S. F., Ross, B., Kanyama, C., Mfinanga, S., Lesikari, S., Heyderman, R. S., Kalata, N., Ellis, J., Kouanfack, C., Chanda, D., Temfack, E., Lakhi, S., Moodley, A., Chan, A. K., Van Oosterhout, J. J., Mapoure, Y., Mwaba, P., Lalloo, D., Wang, D., ... Bicanic, T. (2021). Fungal Burden and Raised Intracranial Pressure Are Independently Associated With Visual Loss in Human Immunodeficiency Virus-Associated Cryptococcal Meningitis. Open Forum Infectious Diseases, 8(4), ofab066. https://doi.org/10.1093/ofid/ofab066

@article{004108f4b0f9468dac491f95cb7daf5c,

title = "Fungal Burden and Raised Intracranial Pressure Are Independently Associated With Visual Loss in Human Immunodeficiency Virus-Associated Cryptococcal Meningitis",

abstract = "Among 472 patients with human immunodeficiency virus-associated cryptococcal meningitis, 16\% had severe visual loss at presentation, and 46\% of these were 4-week survivors and remained severely impaired. Baseline cerebrospinal fluid opening pressure ≥40 cmH2O (adjusted odds ratio [aOR], 2.56; 95\% confidence interval [CI], 1.36–4.83; P = .02) and fungal burden >6.0 log10 colonies/mL (aOR, 3.01; 95\% CI, 1.58–5.7; P = .003) were independently associated with severe visual loss.",

keywords = "cryptococcal meningitis, fungal burden, HIV, raised intracranial pressure, visual loss",

author = "Molloy, \{S{\'i}le F.\} and Brad Ross and Cecilia Kanyama and Sayoki Mfinanga and Sokoine Lesikari and Heyderman, \{Robert S.\} and Newton Kalata and Jayne Ellis and Charles Kouanfack and Duncan Chanda and Elvis Temfack and Shabir Lakhi and Anand Moodley and Chan, \{Adrienne K.\} and \{Van Oosterhout\}, \{Joep J.\} and Yacouba Mapoure and Peter Mwaba and David Lalloo and Duolao Wang and Olivier Lortholary and Shabbar Jaffar and Hosseinipour, \{Mina C.\} and Angela Loyse and Harrison, \{Thomas S.\} and Tihana Bicanic",

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month = apr,

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doi = "10.1093/ofid/ofab066",

language = "English",

volume = "8",

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}

Molloy, SF, Ross, B, Kanyama, C, Mfinanga, S, Lesikari, S, Heyderman, RS, Kalata, N, Ellis, J, Kouanfack, C, Chanda, D, Temfack, E, Lakhi, S, Moodley, A, Chan, AK, Van Oosterhout, JJ, Mapoure, Y, Mwaba, P, Lalloo, D , Wang, D, Lortholary, O, Jaffar, S, Hosseinipour, MC, Loyse, A, Harrison, TS & Bicanic, T 2021, 'Fungal Burden and Raised Intracranial Pressure Are Independently Associated With Visual Loss in Human Immunodeficiency Virus-Associated Cryptococcal Meningitis', Open Forum Infectious Diseases, vol. 8, no. 4, pp. ofab066. https://doi.org/10.1093/ofid/ofab066

TY - JOUR

T1 - Fungal Burden and Raised Intracranial Pressure Are Independently Associated With Visual Loss in Human Immunodeficiency Virus-Associated Cryptococcal Meningitis

AU - Molloy, Síle F.

AU - Ross, Brad

AU - Kanyama, Cecilia

AU - Mfinanga, Sayoki

AU - Lesikari, Sokoine

AU - Heyderman, Robert S.

AU - Kalata, Newton

AU - Ellis, Jayne

AU - Kouanfack, Charles

AU - Chanda, Duncan

AU - Temfack, Elvis

AU - Lakhi, Shabir

AU - Moodley, Anand

AU - Chan, Adrienne K.

AU - Van Oosterhout, Joep J.

AU - Mapoure, Yacouba

AU - Mwaba, Peter

AU - Lalloo, David

AU - Wang, Duolao

AU - Lortholary, Olivier

AU - Jaffar, Shabbar

AU - Hosseinipour, Mina C.

AU - Loyse, Angela

AU - Harrison, Thomas S.

AU - Bicanic, Tihana

PY - 2021/4/1

Y1 - 2021/4/1

N2 - Among 472 patients with human immunodeficiency virus-associated cryptococcal meningitis, 16% had severe visual loss at presentation, and 46% of these were 4-week survivors and remained severely impaired. Baseline cerebrospinal fluid opening pressure ≥40 cmH2O (adjusted odds ratio [aOR], 2.56; 95% confidence interval [CI], 1.36–4.83; P = .02) and fungal burden >6.0 log10 colonies/mL (aOR, 3.01; 95% CI, 1.58–5.7; P = .003) were independently associated with severe visual loss.

AB - Among 472 patients with human immunodeficiency virus-associated cryptococcal meningitis, 16% had severe visual loss at presentation, and 46% of these were 4-week survivors and remained severely impaired. Baseline cerebrospinal fluid opening pressure ≥40 cmH2O (adjusted odds ratio [aOR], 2.56; 95% confidence interval [CI], 1.36–4.83; P = .02) and fungal burden >6.0 log10 colonies/mL (aOR, 3.01; 95% CI, 1.58–5.7; P = .003) were independently associated with severe visual loss.

KW - cryptococcal meningitis

KW - fungal burden

KW - HIV

KW - raised intracranial pressure

KW - visual loss

U2 - 10.1093/ofid/ofab066

DO - 10.1093/ofid/ofab066

M3 - Article

SN - 2328-8957

VL - 8

SP - ofab066

JO - Open Forum Infectious Diseases

JF - Open Forum Infectious Diseases

IS - 4

ER -

Fungal Burden and Raised Intracranial Pressure Are Independently Associated With Visual Loss in Human Immunodeficiency Virus-Associated Cryptococcal Meningitis

Abstract

UN SDGs

Keywords

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