Frequent malaria illness episodes in two Malawian patients on antiretroviral therapy soon after stopping cotrimoxazole preventive therapy

Wongani Nyangulu; Edson Mwinjiwa; Titus H. Divala; Randy G. Mungwira; Osward Nyirenda; Maxwell Kanjala; Gillian Mbambo; Jane Mallewa; Terrie E. Taylor; Matthew B. Laurens; Miriam K. Laufer; Joep J. van Oosterhout

doi:10.4314/mmj.v29i1.12

Frequent malaria illness episodes in two Malawian patients on antiretroviral therapy soon after stopping cotrimoxazole preventive therapy

Wongani Nyangulu, Edson Mwinjiwa, Titus H. Divala, Randy G. Mungwira, Osward Nyirenda, Maxwell Kanjala, Gillian Mbambo, Jane Mallewa, Terrie E. Taylor, Matthew B. Laurens, Miriam K. Laufer, Joep J. van Oosterhout

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Abstract

We describe two Malawian adults on successful antiretroviral therapy who experienced frequent malaria episodes after stopping cotrimoxazole prophylaxis. We argue that, in addition to stopping cotrimoxazole, diminished malaria immunity and drug interactions between efavirenz and artemether-lumefantrine may have played a causative role in the recurrent malaria our patients experienced.

Original language	English
Pages (from-to)	57-60
Number of pages	4
Journal	Malawi Medical Journal
Volume	29
Issue number	1
DOIs	https://doi.org/10.4314/mmj.v29i1.12
Publication status	Published - 1 Jan 2017
Externally published	Yes

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Nyangulu, W., Mwinjiwa, E., Divala, T. H., Mungwira, R. G., Nyirenda, O., Kanjala, M., Mbambo, G., Mallewa, J., Taylor, T. E., Laurens, M. B., Laufer, M. K., & van Oosterhout, J. J. (2017). Frequent malaria illness episodes in two Malawian patients on antiretroviral therapy soon after stopping cotrimoxazole preventive therapy. Malawi Medical Journal, 29(1), 57-60. https://doi.org/10.4314/mmj.v29i1.12

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title = "Frequent malaria illness episodes in two Malawian patients on antiretroviral therapy soon after stopping cotrimoxazole preventive therapy",

abstract = "We describe two Malawian adults on successful antiretroviral therapy who experienced frequent malaria episodes after stopping cotrimoxazole prophylaxis. We argue that, in addition to stopping cotrimoxazole, diminished malaria immunity and drug interactions between efavirenz and artemether-lumefantrine may have played a causative role in the recurrent malaria our patients experienced.",

author = "Wongani Nyangulu and Edson Mwinjiwa and Divala, \{Titus H.\} and Mungwira, \{Randy G.\} and Osward Nyirenda and Maxwell Kanjala and Gillian Mbambo and Jane Mallewa and Taylor, \{Terrie E.\} and Laurens, \{Matthew B.\} and Laufer, \{Miriam K.\} and \{van Oosterhout\}, \{Joep J.\}",

year = "2017",

month = jan,

day = "1",

doi = "10.4314/mmj.v29i1.12",

language = "English",

volume = "29",

pages = "57--60",

journal = "Malawi Medical Journal",

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Nyangulu, W, Mwinjiwa, E, Divala, TH, Mungwira, RG, Nyirenda, O, Kanjala, M, Mbambo, G, Mallewa, J, Taylor, TE, Laurens, MB, Laufer, MK & van Oosterhout, JJ 2017, 'Frequent malaria illness episodes in two Malawian patients on antiretroviral therapy soon after stopping cotrimoxazole preventive therapy', Malawi Medical Journal, vol. 29, no. 1, pp. 57-60. https://doi.org/10.4314/mmj.v29i1.12

TY - JOUR

T1 - Frequent malaria illness episodes in two Malawian patients on antiretroviral therapy soon after stopping cotrimoxazole preventive therapy

AU - Nyangulu, Wongani

AU - Mwinjiwa, Edson

AU - Divala, Titus H.

AU - Mungwira, Randy G.

AU - Nyirenda, Osward

AU - Kanjala, Maxwell

AU - Mbambo, Gillian

AU - Mallewa, Jane

AU - Taylor, Terrie E.

AU - Laurens, Matthew B.

AU - Laufer, Miriam K.

AU - van Oosterhout, Joep J.

PY - 2017/1/1

Y1 - 2017/1/1

N2 - We describe two Malawian adults on successful antiretroviral therapy who experienced frequent malaria episodes after stopping cotrimoxazole prophylaxis. We argue that, in addition to stopping cotrimoxazole, diminished malaria immunity and drug interactions between efavirenz and artemether-lumefantrine may have played a causative role in the recurrent malaria our patients experienced.

AB - We describe two Malawian adults on successful antiretroviral therapy who experienced frequent malaria episodes after stopping cotrimoxazole prophylaxis. We argue that, in addition to stopping cotrimoxazole, diminished malaria immunity and drug interactions between efavirenz and artemether-lumefantrine may have played a causative role in the recurrent malaria our patients experienced.

U2 - 10.4314/mmj.v29i1.12

DO - 10.4314/mmj.v29i1.12

M3 - Article

SN - 1995-7262

VL - 29

SP - 57

EP - 60

JO - Malawi Medical Journal

JF - Malawi Medical Journal

IS - 1

ER -

Frequent malaria illness episodes in two Malawian patients on antiretroviral therapy soon after stopping cotrimoxazole preventive therapy

Abstract

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