Fourth Controlled Human Infection Model (CHIM) meeting – CHIMs in endemic countries, May 22–23, 2023

Melissa Kapulu; Lucinda Manda-Taylor; Shobana Balasingam; Gary Means; Mikal Ayiro Malungu; Philip Bejon; Primus Che Chi; Christopher Chiu; E. Chandler Church; Rodrigo Correa-Oliveira; Nicholas Day; Anna Durbin; Moses Egesa; Claudia Emerson; Kondwani Jambo; Roli Mathur; Wolfram Metzger; Noni Mumba; Winfred Nazziwa; Ally Olotu; Jacqueline Rodgers; Frank Sinyiza; Kawsar Talaat; Ingrid Kamerling; Charlie Weller; Marc Baay; Pieter Neels

doi:10.1016/j.biologicals.2024.101747

Fourth Controlled Human Infection Model (CHIM) meeting – CHIMs in endemic countries, May 22–23, 2023

Melissa Kapulu
, Lucinda Manda-Taylor
, Shobana Balasingam
, Gary Means
, Mikal Ayiro Malungu
, Philip Bejon
, Primus Che Chi
, Christopher Chiu
, E. Chandler Church
, Rodrigo Correa-Oliveira
, Nicholas Day
, Anna Durbin
, Moses Egesa
, Claudia Emerson
, Kondwani Jambo
, Roli Mathur
, Wolfram Metzger
, Noni Mumba
, Winfred Nazziwa
, Ally Olotu

Jacqueline Rodgers, Frank Sinyiza, Kawsar Talaat, Ingrid Kamerling, Charlie Weller, Marc Baay, Pieter Neels

Wellcome Trust Research Laboratories Nairobi
Kamuzu University of Health Sciences
Wellcome Trust
Gates Foundation
Pharmacy and Poisons Board
Imperial College London
Fred Hutchinson Cancer Research Center
Fundação Oswaldo Cruz
Mahidol University
Johns Hopkins University
MRC/UVRI and LSHTM Uganda Research Unit
London School of Hygiene and Tropical Medicine
McMaster University
Malawi-Liverpool-Wellcome Trust Clinical Research Programme
Indian Council of Medical Research
University of Tübingen
Uganda National Council for Science and Technology
Ifakara Health Institute
World Health Organization Regional Office for Africa
National Health Sciences Research Committee
Center for Human Drug Research
P95 CVBA
IABS-EU

Research output: Contribution to journal › Article › peer-review

3 Citations (Scopus)

Abstract

Earlier meetings laid the foundations for Controlled Human Infection Models (CHIMs), also known as human challenge studies and human infection studies, including Good Manufacturing Practice (GMP) production of the challenge agent, CHIM ethics, environmental safety in CHIM, recruitment, community engagement, advertising and incentives, pre-existing immunity, and clinical, immunological, and microbiological endpoints. The fourth CHIM meeting focused on CHIM studies being conducted in endemic countries. Over the last ten years we have seen a vast expansion of the number of countries in Africa performing CHIM studies, as well as a growing number of different challenge organisms being used. Community and public engagement with assiduous ethical and regulatory oversight has been central to successful introductions and should be continued, in more community-led or community-driven models. Valuable initiatives for regulation of CHIMs have been undertaken but further capacity building remains essential.

Original language	English
Article number	101747
Journal	Biologicals
Volume	85
DOIs	https://doi.org/10.1016/j.biologicals.2024.101747
Publication status	Published - 1 Feb 2024
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Deliberate infection
Endemic diseases
Human challenge
Human infection studies
Infectious diseases
Low- and middle-income countries
Vaccine

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10.1016/j.biologicals.2024.101747Licence: CC BY-NC-ND

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Kapulu, M., Manda-Taylor, L., Balasingam, S., Means, G., Ayiro Malungu, M., Bejon, P., Chi, P. C., Chiu, C., Church, E. C., Correa-Oliveira, R., Day, N., Durbin, A., Egesa, M., Emerson, C., Jambo, K., Mathur, R., Metzger, W., Mumba, N., Nazziwa, W., ... Neels, P. (2024). Fourth Controlled Human Infection Model (CHIM) meeting – CHIMs in endemic countries, May 22–23, 2023. Biologicals, 85, Article 101747. https://doi.org/10.1016/j.biologicals.2024.101747

@article{7495acd4868b454893382c464ba647a7,

title = "Fourth Controlled Human Infection Model (CHIM) meeting – CHIMs in endemic countries, May 22–23, 2023",

abstract = "Earlier meetings laid the foundations for Controlled Human Infection Models (CHIMs), also known as human challenge studies and human infection studies, including Good Manufacturing Practice (GMP) production of the challenge agent, CHIM ethics, environmental safety in CHIM, recruitment, community engagement, advertising and incentives, pre-existing immunity, and clinical, immunological, and microbiological endpoints. The fourth CHIM meeting focused on CHIM studies being conducted in endemic countries. Over the last ten years we have seen a vast expansion of the number of countries in Africa performing CHIM studies, as well as a growing number of different challenge organisms being used. Community and public engagement with assiduous ethical and regulatory oversight has been central to successful introductions and should be continued, in more community-led or community-driven models. Valuable initiatives for regulation of CHIMs have been undertaken but further capacity building remains essential.",

keywords = "Deliberate infection, Endemic diseases, Human challenge, Human infection studies, Infectious diseases, Low- and middle-income countries, Vaccine",

author = "Melissa Kapulu and Lucinda Manda-Taylor and Shobana Balasingam and Gary Means and \{Ayiro Malungu\}, Mikal and Philip Bejon and Chi, \{Primus Che\} and Christopher Chiu and Church, \{E. Chandler\} and Rodrigo Correa-Oliveira and Nicholas Day and Anna Durbin and Moses Egesa and Claudia Emerson and Kondwani Jambo and Roli Mathur and Wolfram Metzger and Noni Mumba and Winfred Nazziwa and Ally Olotu and Jacqueline Rodgers and Frank Sinyiza and Kawsar Talaat and Ingrid Kamerling and Charlie Weller and Marc Baay and Pieter Neels",

year = "2024",

month = feb,

day = "1",

doi = "10.1016/j.biologicals.2024.101747",

language = "English",

volume = "85",

journal = "Biologicals",

issn = "1045-1056",

publisher = "Academic Press",

}

Kapulu, M, Manda-Taylor, L, Balasingam, S, Means, G, Ayiro Malungu, M, Bejon, P, Chi, PC, Chiu, C, Church, EC, Correa-Oliveira, R, Day, N, Durbin, A, Egesa, M, Emerson, C, Jambo, K, Mathur, R, Metzger, W, Mumba, N, Nazziwa, W, Olotu, A, Rodgers, J, Sinyiza, F, Talaat, K, Kamerling, I, Weller, C, Baay, M & Neels, P 2024, 'Fourth Controlled Human Infection Model (CHIM) meeting – CHIMs in endemic countries, May 22–23, 2023', Biologicals, vol. 85, 101747. https://doi.org/10.1016/j.biologicals.2024.101747

TY - JOUR

T1 - Fourth Controlled Human Infection Model (CHIM) meeting – CHIMs in endemic countries, May 22–23, 2023

AU - Kapulu, Melissa

AU - Manda-Taylor, Lucinda

AU - Balasingam, Shobana

AU - Means, Gary

AU - Ayiro Malungu, Mikal

AU - Bejon, Philip

AU - Chi, Primus Che

AU - Chiu, Christopher

AU - Church, E. Chandler

AU - Correa-Oliveira, Rodrigo

AU - Day, Nicholas

AU - Durbin, Anna

AU - Egesa, Moses

AU - Emerson, Claudia

AU - Jambo, Kondwani

AU - Mathur, Roli

AU - Metzger, Wolfram

AU - Mumba, Noni

AU - Nazziwa, Winfred

AU - Olotu, Ally

AU - Rodgers, Jacqueline

AU - Sinyiza, Frank

AU - Talaat, Kawsar

AU - Kamerling, Ingrid

AU - Weller, Charlie

AU - Baay, Marc

AU - Neels, Pieter

PY - 2024/2/1

Y1 - 2024/2/1

N2 - Earlier meetings laid the foundations for Controlled Human Infection Models (CHIMs), also known as human challenge studies and human infection studies, including Good Manufacturing Practice (GMP) production of the challenge agent, CHIM ethics, environmental safety in CHIM, recruitment, community engagement, advertising and incentives, pre-existing immunity, and clinical, immunological, and microbiological endpoints. The fourth CHIM meeting focused on CHIM studies being conducted in endemic countries. Over the last ten years we have seen a vast expansion of the number of countries in Africa performing CHIM studies, as well as a growing number of different challenge organisms being used. Community and public engagement with assiduous ethical and regulatory oversight has been central to successful introductions and should be continued, in more community-led or community-driven models. Valuable initiatives for regulation of CHIMs have been undertaken but further capacity building remains essential.

AB - Earlier meetings laid the foundations for Controlled Human Infection Models (CHIMs), also known as human challenge studies and human infection studies, including Good Manufacturing Practice (GMP) production of the challenge agent, CHIM ethics, environmental safety in CHIM, recruitment, community engagement, advertising and incentives, pre-existing immunity, and clinical, immunological, and microbiological endpoints. The fourth CHIM meeting focused on CHIM studies being conducted in endemic countries. Over the last ten years we have seen a vast expansion of the number of countries in Africa performing CHIM studies, as well as a growing number of different challenge organisms being used. Community and public engagement with assiduous ethical and regulatory oversight has been central to successful introductions and should be continued, in more community-led or community-driven models. Valuable initiatives for regulation of CHIMs have been undertaken but further capacity building remains essential.

KW - Deliberate infection

KW - Endemic diseases

KW - Human challenge

KW - Human infection studies

KW - Infectious diseases

KW - Low- and middle-income countries

KW - Vaccine

U2 - 10.1016/j.biologicals.2024.101747

DO - 10.1016/j.biologicals.2024.101747

M3 - Article

SN - 1045-1056

VL - 85

JO - Biologicals

JF - Biologicals

M1 - 101747

ER -

Fourth Controlled Human Infection Model (CHIM) meeting – CHIMs in endemic countries, May 22–23, 2023

Abstract

UN SDGs

Keywords

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