Abstract
Objective To determine the prevalence and determinants of folic acid (FA) supplementation in Chinese couples planning for pregnancy and in women during early pregnancy.
Methods This was a cross-sectional study based on the Shanghai PreConception Cohort (SPCC) study. Data on FA supplementation and socio-demographic features were collected using questionnaires. Couples visiting clinics for pre-pregnancy examination and pregnant women at < 14 gestational weeks were recruited in Shanghai, China, between March 2016 and September 2018.
Results Among the pregnancy planners, 42.4% (4710/11,099) women and 17.1% (1377/8045) men used FA supplements, while 93.4% (14,585/15,615) of the pregnant women used FA supplements. FA supplement use was higher in female pregnancy planners who were older (RR:1.13, 95%CI:1.08–1.18), had higher education (RR:1.71, 95%CI:1.53–1.92), and were residing in urban districts (RR:1.06, 95%CI:1.01–1.11) of FA supplementation; female pregnancy planners with alcohol consumption (RR:0.95, 95%CI:0.90–0.99) had lower odds of FA supplementation. In early pregnancy, women with higher educational level (RR:1.04, 95%CI:1.03–1.06), who underwent pre-pregnancy examination (RR:1.02, 95%CI:1.01–1.03) had higher odds of using an FA supplement; older aged (RR:0.99, 95% CI:0.98–0.99), and multigravida (RR:0.97, 95% CI:0.96–0.98) had lower odds of FA supplementation
| Original language | English |
|---|---|
| Pages (from-to) | 557-565 |
| Number of pages | 9 |
| Journal | Biomedical and Environmental Sciences |
| Volume | 33 |
| Issue number | 8 |
| DOIs | |
| Publication status | Published - 1 Aug 2020 |
Keywords
- Birth defects
- China
- Folic acid supplementation
- Peri-conception
- Pregnancy