Field accuracy of fourth-generation rapid diagnostic tests for acute HIV-1: a systematic review.

Joe Lewis; Peter MacPherson; Emily Adams; Eleanor Ochodo; Anita Sands; Miriam Taegtmeyer

doi:10.1097/qad.0000000000000855

Field accuracy of fourth-generation rapid diagnostic tests for acute HIV-1: a systematic review.

Joe Lewis
, Peter MacPherson
, Emily Adams
, Eleanor Ochodo
, Anita Sands
, Miriam Taegtmeyer

Research output: Contribution to journal › Review article › peer-review

30 Citations (Scopus)

Abstract

INTRODUCTION

Fourth-generation HIV-1 rapid diagnostic tests (RDTs) detect HIV-1 p24 antigen to screen for acute HIV-1. However, diagnostic accuracy during clinical use may be suboptimal.

METHODS

Clinical sensitivity and specificity of fourth-generation RDTs for acute HIV-1 were collated from field evaluation studies in adults identified by a systematic literature search.

RESULTS

Four studies with 17 381 participants from Australia, Swaziland, the United Kingdom and Malawi were identified. All reported 0% sensitivity of the HIV-1 p24 component for acute HIV-1 diagnosis; 26 acute infections were missed. Specificity ranged from 98.3 to 99.9%.

CONCLUSION

Fourth-generation RDTs are currently unsuitable for the detection of acute HIV-1.

Original language	English
Pages (from-to)	2465-2471
Number of pages	7
Journal	AIDS
Volume	29
Issue number	18
DOIs	https://doi.org/10.1097/qad.0000000000000855
Publication status	Published - 28 Nov 2015

Keywords

Acute infection
Diagnostic accuracy
HIV
Point-of-care testing
Rapid diagnostic tests
Systematic review

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1097/qad.0000000000000855

Cite this

@article{9d16960a23884a0c945c159599eac117,

title = "Field accuracy of fourth-generation rapid diagnostic tests for acute HIV-1: a systematic review.",

abstract = "INTRODUCTIONFourth-generation HIV-1 rapid diagnostic tests (RDTs) detect HIV-1 p24 antigen to screen for acute HIV-1. However, diagnostic accuracy during clinical use may be suboptimal.METHODSClinical sensitivity and specificity of fourth-generation RDTs for acute HIV-1 were collated from field evaluation studies in adults identified by a systematic literature search.RESULTSFour studies with 17 381 participants from Australia, Swaziland, the United Kingdom and Malawi were identified. All reported 0\% sensitivity of the HIV-1 p24 component for acute HIV-1 diagnosis; 26 acute infections were missed. Specificity ranged from 98.3 to 99.9\%.CONCLUSIONFourth-generation RDTs are currently unsuitable for the detection of acute HIV-1.",

keywords = "Acute infection, Diagnostic accuracy, HIV, Point-of-care testing, Rapid diagnostic tests, Systematic review",

author = "Joe Lewis and Peter MacPherson and Emily Adams and Eleanor Ochodo and Anita Sands and Miriam Taegtmeyer",

year = "2015",

month = nov,

day = "28",

doi = "10.1097/qad.0000000000000855",

language = "English",

volume = "29",

pages = "2465--2471",

journal = "AIDS",

issn = "0269-9370",

publisher = "Lippincott Williams and Wilkins",

number = "18",

}

TY - JOUR

T1 - Field accuracy of fourth-generation rapid diagnostic tests for acute HIV-1: a systematic review.

AU - Lewis, Joe

AU - MacPherson, Peter

AU - Adams, Emily

AU - Ochodo, Eleanor

AU - Sands, Anita

AU - Taegtmeyer, Miriam

PY - 2015/11/28

Y1 - 2015/11/28

N2 - INTRODUCTIONFourth-generation HIV-1 rapid diagnostic tests (RDTs) detect HIV-1 p24 antigen to screen for acute HIV-1. However, diagnostic accuracy during clinical use may be suboptimal.METHODSClinical sensitivity and specificity of fourth-generation RDTs for acute HIV-1 were collated from field evaluation studies in adults identified by a systematic literature search.RESULTSFour studies with 17 381 participants from Australia, Swaziland, the United Kingdom and Malawi were identified. All reported 0% sensitivity of the HIV-1 p24 component for acute HIV-1 diagnosis; 26 acute infections were missed. Specificity ranged from 98.3 to 99.9%.CONCLUSIONFourth-generation RDTs are currently unsuitable for the detection of acute HIV-1.

AB - INTRODUCTIONFourth-generation HIV-1 rapid diagnostic tests (RDTs) detect HIV-1 p24 antigen to screen for acute HIV-1. However, diagnostic accuracy during clinical use may be suboptimal.METHODSClinical sensitivity and specificity of fourth-generation RDTs for acute HIV-1 were collated from field evaluation studies in adults identified by a systematic literature search.RESULTSFour studies with 17 381 participants from Australia, Swaziland, the United Kingdom and Malawi were identified. All reported 0% sensitivity of the HIV-1 p24 component for acute HIV-1 diagnosis; 26 acute infections were missed. Specificity ranged from 98.3 to 99.9%.CONCLUSIONFourth-generation RDTs are currently unsuitable for the detection of acute HIV-1.

KW - Acute infection

KW - Diagnostic accuracy

KW - HIV

KW - Point-of-care testing

KW - Rapid diagnostic tests

KW - Systematic review

U2 - 10.1097/qad.0000000000000855

DO - 10.1097/qad.0000000000000855

M3 - Review article

SN - 0269-9370

VL - 29

SP - 2465

EP - 2471

JO - AIDS

JF - AIDS

IS - 18

ER -

Field accuracy of fourth-generation rapid diagnostic tests for acute HIV-1: a systematic review.

Abstract

Keywords

UN SDGs

Access to Document

Fingerprint

Cite this