Fibrinogen binding to intercellular adhesion molecule 1: Implications for Plasmodium falciparum adhesion

Carolyn Gray; Alister Craig

doi:10.1128/iai.70.7.3962-3964.2002

Fibrinogen binding to intercellular adhesion molecule 1: Implications for Plasmodium falciparum adhesion

Carolyn Gray
, Alister Craig

Liverpool School of Tropical Medicine

Research output: Contribution to journal › Article › peer-review

10 Citations (Scopus)

Abstract

Intercellular adhesion molecule 1 (ICAM-1) is an endothelial cell adhesion molecule implicated in cerebral malaria. We investigated whether fibrinogen affects Plasmodium falciparum binding to ICAM-1, as the ICAM-1 binding sites of P. falciparum and fibrinogen overlap. We show that fibrinogen dramatically reduces P. falciparum adhesion to ICAM-1 under flow conditions.

Original language	English
Pages (from-to)	3962-3964
Number of pages	3
Journal	Infection and Immunity
Volume	70
Issue number	7
DOIs	https://doi.org/10.1128/iai.70.7.3962-3964.2002
Publication status	Published - 1 Jul 2002

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10.1128/iai.70.7.3962-3964.2002

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title = "Fibrinogen binding to intercellular adhesion molecule 1: Implications for Plasmodium falciparum adhesion",

abstract = "Intercellular adhesion molecule 1 (ICAM-1) is an endothelial cell adhesion molecule implicated in cerebral malaria. We investigated whether fibrinogen affects Plasmodium falciparum binding to ICAM-1, as the ICAM-1 binding sites of P. falciparum and fibrinogen overlap. We show that fibrinogen dramatically reduces P. falciparum adhesion to ICAM-1 under flow conditions.",

author = "Carolyn Gray and Alister Craig",

year = "2002",

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doi = "10.1128/iai.70.7.3962-3964.2002",

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T1 - Fibrinogen binding to intercellular adhesion molecule 1: Implications for Plasmodium falciparum adhesion

AU - Gray, Carolyn

AU - Craig, Alister

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N2 - Intercellular adhesion molecule 1 (ICAM-1) is an endothelial cell adhesion molecule implicated in cerebral malaria. We investigated whether fibrinogen affects Plasmodium falciparum binding to ICAM-1, as the ICAM-1 binding sites of P. falciparum and fibrinogen overlap. We show that fibrinogen dramatically reduces P. falciparum adhesion to ICAM-1 under flow conditions.

AB - Intercellular adhesion molecule 1 (ICAM-1) is an endothelial cell adhesion molecule implicated in cerebral malaria. We investigated whether fibrinogen affects Plasmodium falciparum binding to ICAM-1, as the ICAM-1 binding sites of P. falciparum and fibrinogen overlap. We show that fibrinogen dramatically reduces P. falciparum adhesion to ICAM-1 under flow conditions.

U2 - 10.1128/iai.70.7.3962-3964.2002

DO - 10.1128/iai.70.7.3962-3964.2002

M3 - Article

SN - 0019-9567

VL - 70

SP - 3962

EP - 3964

JO - Infection and Immunity

JF - Infection and Immunity

IS - 7

ER -

Fibrinogen binding to intercellular adhesion molecule 1: Implications for Plasmodium falciparum adhesion

Abstract

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