Abstract
Intercellular adhesion molecule 1 (ICAM-1) is an endothelial cell adhesion molecule implicated in cerebral malaria. We investigated whether fibrinogen affects Plasmodium falciparum binding to ICAM-1, as the ICAM-1 binding sites of P. falciparum and fibrinogen overlap. We show that fibrinogen dramatically reduces P. falciparum adhesion to ICAM-1 under flow conditions.
| Original language | English |
|---|---|
| Pages (from-to) | 3962-3964 |
| Number of pages | 3 |
| Journal | Infection and Immunity |
| Volume | 70 |
| Issue number | 7 |
| DOIs | |
| Publication status | Published - 1 Jul 2002 |
