Fever in uncomplicated plasmodium falciparum malaria: Randomized double-‘blind’ comparison of ibuprofen and paracetamol treatment: Randomized double-‘blind’ comparison of ibuprofen and paracetamol treatment

S. Krishna; S. Pukrittayakamee; W. Supanaranond; Feiko Ter Kuile; M. Ruprah; T. Sura; N. J. White

doi:10.1016/0035-9203(95)90087-x

Fever in uncomplicated plasmodium falciparum malaria: Randomized double-‘blind’ comparison of ibuprofen and paracetamol treatment: Randomized double-‘blind’ comparison of ibuprofen and paracetamol treatment

S. Krishna
, S. Pukrittayakamee
, W. Supanaranond
, Feiko Ter Kuile
, M. Ruprah
, T. Sura
, N. J. White

Mahidol University
John Radcliffe Hospital
Poisons Unit

Research output: Contribution to journal › Article › peer-review

25 Citations (Scopus)

Abstract

Fever almost invariably accompanies uncomplicated falciparum malaria. In a randomized, double-‘blind’ study, we compared a single dose of ibuprofen (10 mg/kg, n = 8) with paracetamol (15 mg/kg, n = 8) for the treatment of fever >38.5 >C due to uncomplicated falciparum malaria. Ibuprofen was significantly more effective than paracetamol in lowering temperatures throughout the first 4.5 h after dosing (P = 0.016) and should be considered as an antipyretic agent in the management of uncomplicated falciparum infections, providing there is no contraindication to its use.

Original language	English
Pages (from-to)	507-509
Number of pages	3
Journal	Transactions of the Royal Society of Tropical Medicine and Hygiene
Volume	89
Issue number	5
DOIs	https://doi.org/10.1016/0035-9203(95)90087-x
Publication status	Published - 1 Sept 1995
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Antipyrexia
Ibuprofen
Malaria
Paracetamol
Plasmodium falciparum

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10.1016/0035-9203(95)90087-x

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Krishna, S., Pukrittayakamee, S., Supanaranond, W., Ter Kuile, F., Ruprah, M., Sura, T., & White, N. J. (1995). Fever in uncomplicated plasmodium falciparum malaria: Randomized double-‘blind’ comparison of ibuprofen and paracetamol treatment: Randomized double-‘blind’ comparison of ibuprofen and paracetamol treatment. Transactions of the Royal Society of Tropical Medicine and Hygiene, 89(5), 507-509. https://doi.org/10.1016/0035-9203(95)90087-x

Krishna, S. ; Pukrittayakamee, S. ; Supanaranond, W. et al. / Fever in uncomplicated plasmodium falciparum malaria: Randomized double-‘blind’ comparison of ibuprofen and paracetamol treatment: Randomized double-‘blind’ comparison of ibuprofen and paracetamol treatment. In: Transactions of the Royal Society of Tropical Medicine and Hygiene. 1995 ; Vol. 89, No. 5. pp. 507-509.

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title = "Fever in uncomplicated plasmodium falciparum malaria: Randomized double-{\textquoteleft}blind{\textquoteright} comparison of ibuprofen and paracetamol treatment: Randomized double-{\textquoteleft}blind{\textquoteright} comparison of ibuprofen and paracetamol treatment",

abstract = "Fever almost invariably accompanies uncomplicated falciparum malaria. In a randomized, double-{\textquoteleft}blind{\textquoteright} study, we compared a single dose of ibuprofen (10 mg/kg, n = 8) with paracetamol (15 mg/kg, n = 8) for the treatment of fever >38.5 >C due to uncomplicated falciparum malaria. Ibuprofen was significantly more effective than paracetamol in lowering temperatures throughout the first 4.5 h after dosing (P = 0.016) and should be considered as an antipyretic agent in the management of uncomplicated falciparum infections, providing there is no contraindication to its use.",

keywords = "Antipyrexia, Ibuprofen, Malaria, Paracetamol, Plasmodium falciparum",

author = "S. Krishna and S. Pukrittayakamee and W. Supanaranond and \{Ter Kuile\}, Feiko and M. Ruprah and T. Sura and White, \{N. J.\}",

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Krishna, S, Pukrittayakamee, S, Supanaranond, W, Ter Kuile, F, Ruprah, M, Sura, T & White, NJ 1995, 'Fever in uncomplicated plasmodium falciparum malaria: Randomized double-‘blind’ comparison of ibuprofen and paracetamol treatment: Randomized double-‘blind’ comparison of ibuprofen and paracetamol treatment', Transactions of the Royal Society of Tropical Medicine and Hygiene, vol. 89, no. 5, pp. 507-509. https://doi.org/10.1016/0035-9203(95)90087-x

Fever in uncomplicated plasmodium falciparum malaria: Randomized double-‘blind’ comparison of ibuprofen and paracetamol treatment: Randomized double-‘blind’ comparison of ibuprofen and paracetamol treatment. / Krishna, S.; Pukrittayakamee, S.; Supanaranond, W. et al.
In: Transactions of the Royal Society of Tropical Medicine and Hygiene, Vol. 89, No. 5, 01.09.1995, p. 507-509.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

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AU - Krishna, S.

AU - Pukrittayakamee, S.

AU - Supanaranond, W.

AU - Ter Kuile, Feiko

AU - Ruprah, M.

AU - Sura, T.

AU - White, N. J.

PY - 1995/9/1

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N2 - Fever almost invariably accompanies uncomplicated falciparum malaria. In a randomized, double-‘blind’ study, we compared a single dose of ibuprofen (10 mg/kg, n = 8) with paracetamol (15 mg/kg, n = 8) for the treatment of fever >38.5 >C due to uncomplicated falciparum malaria. Ibuprofen was significantly more effective than paracetamol in lowering temperatures throughout the first 4.5 h after dosing (P = 0.016) and should be considered as an antipyretic agent in the management of uncomplicated falciparum infections, providing there is no contraindication to its use.

AB - Fever almost invariably accompanies uncomplicated falciparum malaria. In a randomized, double-‘blind’ study, we compared a single dose of ibuprofen (10 mg/kg, n = 8) with paracetamol (15 mg/kg, n = 8) for the treatment of fever >38.5 >C due to uncomplicated falciparum malaria. Ibuprofen was significantly more effective than paracetamol in lowering temperatures throughout the first 4.5 h after dosing (P = 0.016) and should be considered as an antipyretic agent in the management of uncomplicated falciparum infections, providing there is no contraindication to its use.

KW - Antipyrexia

KW - Ibuprofen

KW - Malaria

KW - Paracetamol

KW - Plasmodium falciparum

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Krishna S, Pukrittayakamee S, Supanaranond W, Ter Kuile F, Ruprah M, Sura T et al. Fever in uncomplicated plasmodium falciparum malaria: Randomized double-‘blind’ comparison of ibuprofen and paracetamol treatment: Randomized double-‘blind’ comparison of ibuprofen and paracetamol treatment. Transactions of the Royal Society of Tropical Medicine and Hygiene. 1995 Sept 1;89(5):507-509. doi: 10.1016/0035-9203(95)90087-x