Facile synthesis of quinoxaline annulated perfluoroalkylated benzoazepine derivatives

Gang Liu; Xuechun Sun; Ling Chen; Yueci Wu; Jing Han; Jie Chen; Hongmei Deng; Min Shao; Hui Zhang; Weiguo Cao

doi:10.1039/c6ra22727a

Facile synthesis of quinoxaline annulated perfluoroalkylated benzoazepine derivatives

Gang Liu
, Xuechun Sun
, Ling Chen
, Yueci Wu
, Jing Han
, Jie Chen
, Hongmei Deng
, Min Shao
, Hui Zhang
, Weiguo Cao

Shanghai University
CAS - Shanghai Institute of Organic Chemistry

Research output: Contribution to journal › Article › peer-review

3 Citations (Scopus)

Abstract

Novel perfluoroalkylated benzoazepinoquinoxaline derivatives were synthesized by consecutive intermolecular Michael addition and intramolecular cyclization from 3-(2-aminophenyl)quinoxalin-2(1H)-ones and methyl perfluoroalk-2-ynoates in good yields. This efficient and mild protocol might afford a new pathway for novel drug development.

Original language	English
Pages (from-to)	108154-108157
Number of pages	4
Journal	RSC Advances
Volume	6
Issue number	110
DOIs	https://doi.org/10.1039/c6ra22727a
Publication status	Published - 31 Oct 2016
Externally published	Yes

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title = "Facile synthesis of quinoxaline annulated perfluoroalkylated benzoazepine derivatives",

abstract = "Novel perfluoroalkylated benzoazepinoquinoxaline derivatives were synthesized by consecutive intermolecular Michael addition and intramolecular cyclization from 3-(2-aminophenyl)quinoxalin-2(1H)-ones and methyl perfluoroalk-2-ynoates in good yields. This efficient and mild protocol might afford a new pathway for novel drug development.",

author = "Gang Liu and Xuechun Sun and Ling Chen and Yueci Wu and Jing Han and Jie Chen and Hongmei Deng and Min Shao and Hui Zhang and Weiguo Cao",

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year = "2016",

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T1 - Facile synthesis of quinoxaline annulated perfluoroalkylated benzoazepine derivatives

AU - Liu, Gang

AU - Sun, Xuechun

AU - Chen, Ling

AU - Wu, Yueci

AU - Han, Jing

AU - Chen, Jie

AU - Deng, Hongmei

AU - Shao, Min

AU - Zhang, Hui

AU - Cao, Weiguo

PY - 2016/10/31

Y1 - 2016/10/31

N2 - Novel perfluoroalkylated benzoazepinoquinoxaline derivatives were synthesized by consecutive intermolecular Michael addition and intramolecular cyclization from 3-(2-aminophenyl)quinoxalin-2(1H)-ones and methyl perfluoroalk-2-ynoates in good yields. This efficient and mild protocol might afford a new pathway for novel drug development.

AB - Novel perfluoroalkylated benzoazepinoquinoxaline derivatives were synthesized by consecutive intermolecular Michael addition and intramolecular cyclization from 3-(2-aminophenyl)quinoxalin-2(1H)-ones and methyl perfluoroalk-2-ynoates in good yields. This efficient and mild protocol might afford a new pathway for novel drug development.

U2 - 10.1039/c6ra22727a

DO - 10.1039/c6ra22727a

M3 - Article

AN - SCOPUS:84997501377

SN - 2046-2069

VL - 6

SP - 108154

EP - 108157

JO - RSC Advances

JF - RSC Advances

IS - 110

ER -

Facile synthesis of quinoxaline annulated perfluoroalkylated benzoazepine derivatives

Abstract

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