Evolutionary analysis of novel serine proteases in the venom gland transcriptome of Bitis gabonica rhinoceros.

Sakthivel Vaiyapuri; Simon Wagstaff; Robert Harrison; Jonathan M. Gibbins; E. Gail Hutchinson

doi:10.1371/journal.pone.0021532

Evolutionary analysis of novel serine proteases in the venom gland transcriptome of Bitis gabonica rhinoceros.

Sakthivel Vaiyapuri
, Simon Wagstaff
, Robert Harrison
, Jonathan M. Gibbins
, E. Gail Hutchinson

Tropical Disease Biology

Research output: Contribution to journal › Article › peer-review

30 Citations (Scopus)

Abstract

Our study provides further insight into the diversity of serine protease isoforms present within snake venom and discusses their possible functions and how they may have evolved. These multiple serine protease isoforms with different substrate specificities may enhance the envenomation effects and help the snake to adapt to new habitats and diets. Our findings have potential for helping the future development of improved therapeutics for snake bites.

Original language	English
Article number	e21532
Pages (from-to)	e21532
Journal	PLoS ONE
Volume	6
Issue number	6
DOIs	https://doi.org/10.1371/journal.pone.0021532
Publication status	Published - 24 Jun 2011

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10.1371/journal.pone.0021532Licence: CC BY

Plos ONE 6 6 e21532Final published version, 2.79 MBLicence: CC BY

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title = "Evolutionary analysis of novel serine proteases in the venom gland transcriptome of Bitis gabonica rhinoceros.",

abstract = "Our study provides further insight into the diversity of serine protease isoforms present within snake venom and discusses their possible functions and how they may have evolved. These multiple serine protease isoforms with different substrate specificities may enhance the envenomation effects and help the snake to adapt to new habitats and diets. Our findings have potential for helping the future development of improved therapeutics for snake bites.",

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AB - Our study provides further insight into the diversity of serine protease isoforms present within snake venom and discusses their possible functions and how they may have evolved. These multiple serine protease isoforms with different substrate specificities may enhance the envenomation effects and help the snake to adapt to new habitats and diets. Our findings have potential for helping the future development of improved therapeutics for snake bites.

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Evolutionary analysis of novel serine proteases in the venom gland transcriptome of Bitis gabonica rhinoceros.

Abstract

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