TY - JOUR
T1 - Evolution of the insecticide target Rdl in African Anopheles is driven by interspecific and interkaryotypic introgression
AU - Grau-Bové, Xavier
AU - Tomlinson, Sean
AU - O'Reilly, Andrias O.
AU - Harding, Nicholas J.
AU - Miles, Alistair
AU - Kwiatkowski, Dominic
AU - Donnelly, Martin
AU - Weetman, David
PY - 2020/10/1
Y1 - 2020/10/1
N2 - The evolution of insecticide resistance mechanisms in natural populations of Anopheles malaria vectors is a major public health concern across Africa. Using genome sequence data, we study the evolution of resistance mutations in the resistance to dieldrin locus (Rdl), a GABA receptor targeted by several insecticides, but most notably by the long-discontinued cyclodiene, dieldrin. The two Rdl resistance mutations (296G and 296S) spread across West and Central African Anopheles viatwo independent hard selective sweeps that included likely compensatory nearby mutations, and were followed by a rare combination of introgression across species (from A. gambiae and A. arabiensis to A. coluzzii) and across non-concordant karyotypes of the 2La chromosomal inversion. Rdl resistance evolved in the 1950s as the first known adaptation to a large-scale insecticidebased intervention, but the evolutionary lessons from this system highlight contemporary and future dangers for management strategies designed to combat development of resistance in malaria vectors.
AB - The evolution of insecticide resistance mechanisms in natural populations of Anopheles malaria vectors is a major public health concern across Africa. Using genome sequence data, we study the evolution of resistance mutations in the resistance to dieldrin locus (Rdl), a GABA receptor targeted by several insecticides, but most notably by the long-discontinued cyclodiene, dieldrin. The two Rdl resistance mutations (296G and 296S) spread across West and Central African Anopheles viatwo independent hard selective sweeps that included likely compensatory nearby mutations, and were followed by a rare combination of introgression across species (from A. gambiae and A. arabiensis to A. coluzzii) and across non-concordant karyotypes of the 2La chromosomal inversion. Rdl resistance evolved in the 1950s as the first known adaptation to a large-scale insecticidebased intervention, but the evolutionary lessons from this system highlight contemporary and future dangers for management strategies designed to combat development of resistance in malaria vectors.
KW - Insect vectors
KW - Insecticide resistance
KW - Population genomics
U2 - 10.1093/molbev/msaa128
DO - 10.1093/molbev/msaa128
M3 - Article
SN - 0737-4038
VL - 37
SP - 2900
EP - 2917
JO - Molecular Biology and Evolution
JF - Molecular Biology and Evolution
IS - 10
ER -
