Evidence of promiscuous endothelial binding by Plasmodium falciparum-infected erythrocytes.

Claudia Esser; Anna Bachmann; Daniela Kuhn; Kathrin Schuldt; Birgit Förster; Meike Thiel; Jürgen May; Friedrich Koch-Nolte; María Yáñez-Mó; Francisco Sánchez-Madrid; Alfred H. Schinkel; Sirpa Jalkanen; Alister Craig; Iris Bruchhaus; Rolf D. Horstmann

doi:10.1111/cmi.12270

Evidence of promiscuous endothelial binding by Plasmodium falciparum-infected erythrocytes.

Claudia Esser, Anna Bachmann, Daniela Kuhn, Kathrin Schuldt, Birgit Förster, Meike Thiel, Jürgen May, Friedrich Koch-Nolte, María Yáñez-Mó, Francisco Sánchez-Madrid, Alfred H. Schinkel, Sirpa Jalkanen, Alister Craig, Iris Bruchhaus, Rolf D. Horstmann

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Abstract

The adhesion of infected red blood cells (iRBCs) to human endothelium is considered a key event in the pathogenesis of cerebral malaria and other life-threatening complications caused by the most prevalent malaria parasite Plasmodium falciparum. In the past 30 years, 14 endothelial receptors for iRBCs have been identified. Exposing 10 additional surface proteins of endothelial cells to a mixture of P. falciparum isolates from three Ghanaian malaria patients, we identified seven new iRBC receptors, all expressed in brain vessels. This finding strongly suggests that endothelial binding of P. falciparum iRBCs is promiscuous and may use a combination of endothelial surface moieties.

Original language	English
Pages (from-to)	701-708
Number of pages	8
Journal	Cellular Microbiology
Volume	16
Issue number	5
DOIs	https://doi.org/10.1111/cmi.12270
Publication status	Published - 1 May 2014

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Esser, C., Bachmann, A., Kuhn, D., Schuldt, K., Förster, B., Thiel, M., May, J., Koch-Nolte, F., Yáñez-Mó, M., Sánchez-Madrid, F., Schinkel, A. H., Jalkanen, S., Craig, A., Bruchhaus, I., & Horstmann, R. D. (2014). Evidence of promiscuous endothelial binding by Plasmodium falciparum-infected erythrocytes. Cellular Microbiology, 16(5), 701-708. https://doi.org/10.1111/cmi.12270

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title = "Evidence of promiscuous endothelial binding by Plasmodium falciparum-infected erythrocytes.",

abstract = "The adhesion of infected red blood cells (iRBCs) to human endothelium is considered a key event in the pathogenesis of cerebral malaria and other life-threatening complications caused by the most prevalent malaria parasite Plasmodium falciparum. In the past 30 years, 14 endothelial receptors for iRBCs have been identified. Exposing 10 additional surface proteins of endothelial cells to a mixture of P. falciparum isolates from three Ghanaian malaria patients, we identified seven new iRBC receptors, all expressed in brain vessels. This finding strongly suggests that endothelial binding of P. falciparum iRBCs is promiscuous and may use a combination of endothelial surface moieties.",

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Esser, C, Bachmann, A, Kuhn, D, Schuldt, K, Förster, B, Thiel, M, May, J, Koch-Nolte, F, Yáñez-Mó, M, Sánchez-Madrid, F, Schinkel, AH, Jalkanen, S, Craig, A, Bruchhaus, I & Horstmann, RD 2014, 'Evidence of promiscuous endothelial binding by Plasmodium falciparum-infected erythrocytes.', Cellular Microbiology, vol. 16, no. 5, pp. 701-708. https://doi.org/10.1111/cmi.12270

TY - JOUR

T1 - Evidence of promiscuous endothelial binding by Plasmodium falciparum-infected erythrocytes.

AU - Esser, Claudia

AU - Bachmann, Anna

AU - Kuhn, Daniela

AU - Schuldt, Kathrin

AU - Förster, Birgit

AU - Thiel, Meike

AU - May, Jürgen

AU - Koch-Nolte, Friedrich

AU - Yáñez-Mó, María

AU - Sánchez-Madrid, Francisco

AU - Schinkel, Alfred H.

AU - Jalkanen, Sirpa

AU - Craig, Alister

AU - Bruchhaus, Iris

AU - Horstmann, Rolf D.

PY - 2014/5/1

Y1 - 2014/5/1

N2 - The adhesion of infected red blood cells (iRBCs) to human endothelium is considered a key event in the pathogenesis of cerebral malaria and other life-threatening complications caused by the most prevalent malaria parasite Plasmodium falciparum. In the past 30 years, 14 endothelial receptors for iRBCs have been identified. Exposing 10 additional surface proteins of endothelial cells to a mixture of P. falciparum isolates from three Ghanaian malaria patients, we identified seven new iRBC receptors, all expressed in brain vessels. This finding strongly suggests that endothelial binding of P. falciparum iRBCs is promiscuous and may use a combination of endothelial surface moieties.

AB - The adhesion of infected red blood cells (iRBCs) to human endothelium is considered a key event in the pathogenesis of cerebral malaria and other life-threatening complications caused by the most prevalent malaria parasite Plasmodium falciparum. In the past 30 years, 14 endothelial receptors for iRBCs have been identified. Exposing 10 additional surface proteins of endothelial cells to a mixture of P. falciparum isolates from three Ghanaian malaria patients, we identified seven new iRBC receptors, all expressed in brain vessels. This finding strongly suggests that endothelial binding of P. falciparum iRBCs is promiscuous and may use a combination of endothelial surface moieties.

U2 - 10.1111/cmi.12270

DO - 10.1111/cmi.12270

M3 - Article

SN - 1462-5814

VL - 16

SP - 701

EP - 708

JO - Cellular Microbiology

JF - Cellular Microbiology

IS - 5

ER -

Evidence of promiscuous endothelial binding by Plasmodium falciparum-infected erythrocytes.

Abstract

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