Evidence of exposure to SARS-CoV-2 in cats and dogs from households in Italy

Ian Patterson; G. Elia; A. Grassi; A. Giordano; C. Desario; M. Medardo; S. L. Smith; Enya Anderson; T. Prince; G. T. Patterson; E. Lorusso; M. S. Lucente; G. Lanave; S. Lauzi; U. Bonfanti; A. Stranieri; V. Martella; F. Solari Basano; V. R. Barrs; A. D. Radford; U. Agrimi; Grant Hughes; S. Paltrinieri; N. Decaro

doi:10.1038/s41467-020-20097-0

Evidence of exposure to SARS-CoV-2 in cats and dogs from households in Italy

Ian Patterson, G. Elia, A. Grassi, A. Giordano, C. Desario, M. Medardo, S. L. Smith, Enya Anderson, T. Prince, G. T. Patterson, E. Lorusso, M. S. Lucente, G. Lanave, S. Lauzi, U. Bonfanti, A. Stranieri, V. Martella, F. Solari Basano, V. R. Barrs, A. D. RadfordU. Agrimi, Grant Hughes, S. Paltrinieri, N. Decaro

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Abstract

SARS-CoV-2 emerged from animals and is now easily transmitted between people. Sporadic detection of natural cases in animals alongside successful experimental infections of pets, such as cats, ferrets and dogs, raises questions about the susceptibility of animals under natural conditions of pet ownership. Here, we report a large-scale study to assess SARS-CoV-2 infection in 919 companion animals living in northern Italy, sampled at a time of frequent human infection. No animals tested PCR positive. However, 3.3% of dogs and 5.8% of cats had measurable SARS-CoV-2 neutralizing antibody titers, with dogs from COVID-19 positive households being significantly more likely to test positive than those from COVID-19 negative households. Understanding risk factors associated with this and their potential to infect other species requires urgent investigation.

Original language	English
Article number	6231
Pages (from-to)	6231
Journal	Nature Communications
Volume	11
Issue number	1
DOIs	https://doi.org/10.1038/s41467-020-20097-0
Publication status	Published - 4 Dec 2020

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41467 2020 Article 20097Final published version, 870 KBLicence: CC BY

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Patterson, I., Elia, G., Grassi, A., Giordano, A., Desario, C., Medardo, M., Smith, S. L., Anderson, E., Prince, T., Patterson, G. T., Lorusso, E., Lucente, M. S., Lanave, G., Lauzi, S., Bonfanti, U., Stranieri, A., Martella, V., Solari Basano, F., Barrs, V. R., ... Decaro, N. (2020). Evidence of exposure to SARS-CoV-2 in cats and dogs from households in Italy. Nature Communications, 11(1), 6231. Article 6231. https://doi.org/10.1038/s41467-020-20097-0

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title = "Evidence of exposure to SARS-CoV-2 in cats and dogs from households in Italy",

abstract = "SARS-CoV-2 emerged from animals and is now easily transmitted between people. Sporadic detection of natural cases in animals alongside successful experimental infections of pets, such as cats, ferrets and dogs, raises questions about the susceptibility of animals under natural conditions of pet ownership. Here, we report a large-scale study to assess SARS-CoV-2 infection in 919 companion animals living in northern Italy, sampled at a time of frequent human infection. No animals tested PCR positive. However, 3.3\% of dogs and 5.8\% of cats had measurable SARS-CoV-2 neutralizing antibody titers, with dogs from COVID-19 positive households being significantly more likely to test positive than those from COVID-19 negative households. Understanding risk factors associated with this and their potential to infect other species requires urgent investigation.",

author = "Ian Patterson and G. Elia and A. Grassi and A. Giordano and C. Desario and M. Medardo and Smith, \{S. L.\} and Enya Anderson and T. Prince and Patterson, \{G. T.\} and E. Lorusso and Lucente, \{M. S.\} and G. Lanave and S. Lauzi and U. Bonfanti and A. Stranieri and V. Martella and \{Solari Basano\}, F. and Barrs, \{V. R.\} and Radford, \{A. D.\} and U. Agrimi and Grant Hughes and S. Paltrinieri and N. Decaro",

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doi = "10.1038/s41467-020-20097-0",

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Patterson, I, Elia, G, Grassi, A, Giordano, A, Desario, C, Medardo, M, Smith, SL, Anderson, E, Prince, T, Patterson, GT, Lorusso, E, Lucente, MS, Lanave, G, Lauzi, S, Bonfanti, U, Stranieri, A, Martella, V, Solari Basano, F, Barrs, VR, Radford, AD, Agrimi, U, Hughes, G, Paltrinieri, S & Decaro, N 2020, 'Evidence of exposure to SARS-CoV-2 in cats and dogs from households in Italy', Nature Communications, vol. 11, no. 1, 6231, pp. 6231. https://doi.org/10.1038/s41467-020-20097-0

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T1 - Evidence of exposure to SARS-CoV-2 in cats and dogs from households in Italy

AU - Patterson, Ian

AU - Elia, G.

AU - Grassi, A.

AU - Giordano, A.

AU - Desario, C.

AU - Medardo, M.

AU - Smith, S. L.

AU - Anderson, Enya

AU - Prince, T.

AU - Patterson, G. T.

AU - Lorusso, E.

AU - Lucente, M. S.

AU - Lanave, G.

AU - Lauzi, S.

AU - Bonfanti, U.

AU - Stranieri, A.

AU - Martella, V.

AU - Solari Basano, F.

AU - Barrs, V. R.

AU - Radford, A. D.

AU - Agrimi, U.

AU - Hughes, Grant

AU - Paltrinieri, S.

AU - Decaro, N.

PY - 2020/12/4

Y1 - 2020/12/4

N2 - SARS-CoV-2 emerged from animals and is now easily transmitted between people. Sporadic detection of natural cases in animals alongside successful experimental infections of pets, such as cats, ferrets and dogs, raises questions about the susceptibility of animals under natural conditions of pet ownership. Here, we report a large-scale study to assess SARS-CoV-2 infection in 919 companion animals living in northern Italy, sampled at a time of frequent human infection. No animals tested PCR positive. However, 3.3% of dogs and 5.8% of cats had measurable SARS-CoV-2 neutralizing antibody titers, with dogs from COVID-19 positive households being significantly more likely to test positive than those from COVID-19 negative households. Understanding risk factors associated with this and their potential to infect other species requires urgent investigation.

AB - SARS-CoV-2 emerged from animals and is now easily transmitted between people. Sporadic detection of natural cases in animals alongside successful experimental infections of pets, such as cats, ferrets and dogs, raises questions about the susceptibility of animals under natural conditions of pet ownership. Here, we report a large-scale study to assess SARS-CoV-2 infection in 919 companion animals living in northern Italy, sampled at a time of frequent human infection. No animals tested PCR positive. However, 3.3% of dogs and 5.8% of cats had measurable SARS-CoV-2 neutralizing antibody titers, with dogs from COVID-19 positive households being significantly more likely to test positive than those from COVID-19 negative households. Understanding risk factors associated with this and their potential to infect other species requires urgent investigation.

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JF - Nature Communications

IS - 1

M1 - 6231

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Evidence of exposure to SARS-CoV-2 in cats and dogs from households in Italy

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