Evidence of ebola virus replication and high concentration in semen of a patient during recovery

Kayla Barnes; Jason Kindrachuk; Aaron E. Lin; Shirlee Wohl; James Qu; Samantha D. Tostenson; William R. Dorman; Michele Busby; Katherine J. Siddle; Cynthia Y. Luo; Christian B. Matranga; Richard T. Davey; Pardis C. Sabeti; Daniel S. Chertow

doi:10.1093/cid/cix518

Evidence of ebola virus replication and high concentration in semen of a patient during recovery

Kayla Barnes
, Jason Kindrachuk
, Aaron E. Lin
, Shirlee Wohl
, James Qu
, Samantha D. Tostenson
, William R. Dorman
, Michele Busby
, Katherine J. Siddle
, Cynthia Y. Luo
, Christian B. Matranga
, Richard T. Davey
, Pardis C. Sabeti
, Daniel S. Chertow

Harvard University
Broad Institute
National Institutes of Health
United States Army Medical Research Institute of Infectious Diseases

Research output: Contribution to journal › Article › peer-review

27 Citations (Scopus)

Abstract

In one patient over time, we found that concentration of Ebola virus RNA in semen during recovery is remarkably higher than blood at peak illness. Virus in semen is replication-competent with no change in viral genome over time. Presence of sense RNA suggests replication in cells present in semen.

Original language	English
Pages (from-to)	1400-1403
Number of pages	4
Journal	Clinical Infectious Diseases
Volume	65
Issue number	8
DOIs	https://doi.org/10.1093/cid/cix518
Publication status	Published - 1 Oct 2017
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Ebola
Persistence
Replication
Semen
Sexual transmission

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10.1093/cid/cix518

Cite this

Barnes, K., Kindrachuk, J., Lin, A. E., Wohl, S., Qu, J., Tostenson, S. D., Dorman, W. R., Busby, M., Siddle, K. J., Luo, C. Y., Matranga, C. B., Davey, R. T., Sabeti, P. C., & Chertow, D. S. (2017). Evidence of ebola virus replication and high concentration in semen of a patient during recovery. Clinical Infectious Diseases, 65(8), 1400-1403. https://doi.org/10.1093/cid/cix518

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abstract = "In one patient over time, we found that concentration of Ebola virus RNA in semen during recovery is remarkably higher than blood at peak illness. Virus in semen is replication-competent with no change in viral genome over time. Presence of sense RNA suggests replication in cells present in semen.",

keywords = "Ebola, Persistence, Replication, Semen, Sexual transmission",

author = "Kayla Barnes and Jason Kindrachuk and Lin, \{Aaron E.\} and Shirlee Wohl and James Qu and Tostenson, \{Samantha D.\} and Dorman, \{William R.\} and Michele Busby and Siddle, \{Katherine J.\} and Luo, \{Cynthia Y.\} and Matranga, \{Christian B.\} and Davey, \{Richard T.\} and Sabeti, \{Pardis C.\} and Chertow, \{Daniel S.\}",

year = "2017",

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doi = "10.1093/cid/cix518",

language = "English",

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T1 - Evidence of ebola virus replication and high concentration in semen of a patient during recovery

AU - Barnes, Kayla

AU - Kindrachuk, Jason

AU - Lin, Aaron E.

AU - Wohl, Shirlee

AU - Qu, James

AU - Tostenson, Samantha D.

AU - Dorman, William R.

AU - Busby, Michele

AU - Siddle, Katherine J.

AU - Luo, Cynthia Y.

AU - Matranga, Christian B.

AU - Davey, Richard T.

AU - Sabeti, Pardis C.

AU - Chertow, Daniel S.

PY - 2017/10/1

Y1 - 2017/10/1

N2 - In one patient over time, we found that concentration of Ebola virus RNA in semen during recovery is remarkably higher than blood at peak illness. Virus in semen is replication-competent with no change in viral genome over time. Presence of sense RNA suggests replication in cells present in semen.

AB - In one patient over time, we found that concentration of Ebola virus RNA in semen during recovery is remarkably higher than blood at peak illness. Virus in semen is replication-competent with no change in viral genome over time. Presence of sense RNA suggests replication in cells present in semen.

KW - Ebola

KW - Persistence

KW - Replication

KW - Semen

KW - Sexual transmission

U2 - 10.1093/cid/cix518

DO - 10.1093/cid/cix518

M3 - Article

SN - 1058-4838

VL - 65

SP - 1400

EP - 1403

JO - Clinical Infectious Diseases

JF - Clinical Infectious Diseases

IS - 8

ER -

Evidence of ebola virus replication and high concentration in semen of a patient during recovery

Abstract

UN SDGs

Keywords

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