Evidence for a common non-heme chelatable-iron-dependent activation mechanism for semisynthetic and synthetic endoperoxide antimalarial drugs

Paul A. Stocks; Patrick G. Bray; Victoria E. Barton; Mohammed Al-Helal; Michael Jones; Nuna C. Araujo; Peter Gibbons; Steve Ward; Ruth H. Hughes; Giancarlo Biagini; Jill Davies; Richard Amewu; Amy E. Mercer; Gemma Ellis; Paul M. O'Neill

doi:10.1002/anie.200604697

Evidence for a common non-heme chelatable-iron-dependent activation mechanism for semisynthetic and synthetic endoperoxide antimalarial drugs

Paul A. Stocks, Patrick G. Bray, Victoria E. Barton, Mohammed Al-Helal, Michael Jones, Nuna C. Araujo, Peter Gibbons, Steve Ward, Ruth H. Hughes, Giancarlo Biagini, Jill Davies, Richard Amewu, Amy E. Mercer, Gemma Ellis, Paul M. O'Neill

Tropical Disease Biology

Research output: Contribution to journal › Article › peer-review

122 Citations (Scopus)

Original language	English
Pages (from-to)	6278-6283
Number of pages	6
Journal	Angewandte Chemie - International Edition
Volume	46
Issue number	33
DOIs	https://doi.org/10.1002/anie.200604697
Publication status	Published - 20 Aug 2007

Keywords

Antimalarial agents
Chelates
Confocal imaging
Fluorescence
Iron

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10.1002/anie.200604697

Cite this

Stocks, P. A., Bray, P. G., Barton, V. E., Al-Helal, M., Jones, M., Araujo, N. C., Gibbons, P., Ward, S., Hughes, R. H., Biagini, G., Davies, J., Amewu, R., Mercer, A. E., Ellis, G., & O'Neill, P. M. (2007). Evidence for a common non-heme chelatable-iron-dependent activation mechanism for semisynthetic and synthetic endoperoxide antimalarial drugs. Angewandte Chemie - International Edition, 46(33), 6278-6283. https://doi.org/10.1002/anie.200604697

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title = "Evidence for a common non-heme chelatable-iron-dependent activation mechanism for semisynthetic and synthetic endoperoxide antimalarial drugs",

keywords = "Antimalarial agents, Chelates, Confocal imaging, Fluorescence, Iron",

author = "Stocks, \{Paul A.\} and Bray, \{Patrick G.\} and Barton, \{Victoria E.\} and Mohammed Al-Helal and Michael Jones and Araujo, \{Nuna C.\} and Peter Gibbons and Steve Ward and Hughes, \{Ruth H.\} and Giancarlo Biagini and Jill Davies and Richard Amewu and Mercer, \{Amy E.\} and Gemma Ellis and O'Neill, \{Paul M.\}",

year = "2007",

month = aug,

day = "20",

doi = "10.1002/anie.200604697",

language = "English",

volume = "46",

pages = "6278--6283",

journal = "Angewandte Chemie - International Edition",

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Stocks, PA, Bray, PG, Barton, VE, Al-Helal, M, Jones, M, Araujo, NC, Gibbons, P, Ward, S, Hughes, RH, Biagini, G , Davies, J, Amewu, R, Mercer, AE, Ellis, G & O'Neill, PM 2007, 'Evidence for a common non-heme chelatable-iron-dependent activation mechanism for semisynthetic and synthetic endoperoxide antimalarial drugs', Angewandte Chemie - International Edition, vol. 46, no. 33, pp. 6278-6283. https://doi.org/10.1002/anie.200604697

TY - JOUR

T1 - Evidence for a common non-heme chelatable-iron-dependent activation mechanism for semisynthetic and synthetic endoperoxide antimalarial drugs

AU - Stocks, Paul A.

AU - Bray, Patrick G.

AU - Barton, Victoria E.

AU - Al-Helal, Mohammed

AU - Jones, Michael

AU - Araujo, Nuna C.

AU - Gibbons, Peter

AU - Ward, Steve

AU - Hughes, Ruth H.

AU - Biagini, Giancarlo

AU - Davies, Jill

AU - Amewu, Richard

AU - Mercer, Amy E.

AU - Ellis, Gemma

AU - O'Neill, Paul M.

PY - 2007/8/20

Y1 - 2007/8/20

KW - Antimalarial agents

KW - Chelates

KW - Confocal imaging

KW - Fluorescence

KW - Iron

U2 - 10.1002/anie.200604697

DO - 10.1002/anie.200604697

M3 - Article

SN - 1433-7851

VL - 46

SP - 6278

EP - 6283

JO - Angewandte Chemie - International Edition

JF - Angewandte Chemie - International Edition

IS - 33

ER -