Evidence for a common non-heme chelatable-iron-dependent activation mechanism for semisynthetic and synthetic endoperoxide antimalarial drugs

Paul A. Stocks; Patrick G. Bray; Victoria E. Barton; Mohammed Al-Helal; Michael Jones; Nuna C. Araujo; Peter Gibbons; Steve Ward; Ruth H. Hughes; Giancarlo Biagini; Jill Davies; Richard Amewu; Amy E. Mercer; Gemma Ellis; Paul M. O'Neill

doi:10.1002/anie.200604697

Evidence for a common non-heme chelatable-iron-dependent activation mechanism for semisynthetic and synthetic endoperoxide antimalarial drugs

Paul A. Stocks
, Patrick G. Bray
, Victoria E. Barton
, Mohammed Al-Helal
, Michael Jones
, Nuna C. Araujo
, Peter Gibbons
, Steve Ward
, Ruth H. Hughes
, Giancarlo Biagini
, Jill Davies
, Richard Amewu
, Amy E. Mercer
, Gemma Ellis
, Paul M. O'Neill

Tropical Disease Biology

Research output: Contribution to journal › Article › peer-review

122 Citations (Scopus)

Original language	English
Pages (from-to)	6278-6283
Number of pages	6
Journal	Angewandte Chemie - International Edition
Volume	46
Issue number	33
DOIs	https://doi.org/10.1002/anie.200604697
Publication status	Published - 20 Aug 2007

Keywords

Antimalarial agents
Chelates
Confocal imaging
Fluorescence
Iron

Access to Document

10.1002/anie.200604697

Cite this

Stocks, P. A., Bray, P. G., Barton, V. E., Al-Helal, M., Jones, M., Araujo, N. C., Gibbons, P., Ward, S., Hughes, R. H., Biagini, G., Davies, J., Amewu, R., Mercer, A. E., Ellis, G., & O'Neill, P. M. (2007). Evidence for a common non-heme chelatable-iron-dependent activation mechanism for semisynthetic and synthetic endoperoxide antimalarial drugs. Angewandte Chemie - International Edition, 46(33), 6278-6283. https://doi.org/10.1002/anie.200604697

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title = "Evidence for a common non-heme chelatable-iron-dependent activation mechanism for semisynthetic and synthetic endoperoxide antimalarial drugs",

keywords = "Antimalarial agents, Chelates, Confocal imaging, Fluorescence, Iron",

author = "Stocks, \{Paul A.\} and Bray, \{Patrick G.\} and Barton, \{Victoria E.\} and Mohammed Al-Helal and Michael Jones and Araujo, \{Nuna C.\} and Peter Gibbons and Steve Ward and Hughes, \{Ruth H.\} and Giancarlo Biagini and Jill Davies and Richard Amewu and Mercer, \{Amy E.\} and Gemma Ellis and O'Neill, \{Paul M.\}",

year = "2007",

month = aug,

day = "20",

doi = "10.1002/anie.200604697",

language = "English",

volume = "46",

pages = "6278--6283",

journal = "Angewandte Chemie - International Edition",

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Stocks, PA, Bray, PG, Barton, VE, Al-Helal, M, Jones, M, Araujo, NC, Gibbons, P, Ward, S, Hughes, RH, Biagini, G , Davies, J, Amewu, R, Mercer, AE, Ellis, G & O'Neill, PM 2007, 'Evidence for a common non-heme chelatable-iron-dependent activation mechanism for semisynthetic and synthetic endoperoxide antimalarial drugs', Angewandte Chemie - International Edition, vol. 46, no. 33, pp. 6278-6283. https://doi.org/10.1002/anie.200604697

TY - JOUR

T1 - Evidence for a common non-heme chelatable-iron-dependent activation mechanism for semisynthetic and synthetic endoperoxide antimalarial drugs

AU - Stocks, Paul A.

AU - Bray, Patrick G.

AU - Barton, Victoria E.

AU - Al-Helal, Mohammed

AU - Jones, Michael

AU - Araujo, Nuna C.

AU - Gibbons, Peter

AU - Ward, Steve

AU - Hughes, Ruth H.

AU - Biagini, Giancarlo

AU - Davies, Jill

AU - Amewu, Richard

AU - Mercer, Amy E.

AU - Ellis, Gemma

AU - O'Neill, Paul M.

PY - 2007/8/20

Y1 - 2007/8/20

KW - Antimalarial agents

KW - Chelates

KW - Confocal imaging

KW - Fluorescence

KW - Iron

U2 - 10.1002/anie.200604697

DO - 10.1002/anie.200604697

M3 - Article

SN - 1433-7851

VL - 46

SP - 6278

EP - 6283

JO - Angewandte Chemie - International Edition

JF - Angewandte Chemie - International Edition

IS - 33

ER -