Evidence-based guidelines for supportive care of patients with Ebola virus disease

François Lamontagne; Robert A. Fowler; Neill K. Adhikari; Srinivas Murthy; David M. Brett-Major; Michael Jacobs; Timothy M. Uyeki; Constanza Vallenas; Susan L. Norris; William A. Fischer; Tom Fletcher; Adam C. Levine; Paul Reed; Daniel G. Bausch; Sandy Gove; Andrew Hall; Susan Shepherd; Reed A. Siemieniuk; Marie Claude Lamah; Rashida Kamara; Phiona Nakyeyune; Moses J. Soka; Ama Edwin; Afeez A. Hazzan; Shevin Jacob; Mubarak Mustafa Elkarsany; Takuya Adachi; Lynda Benhadj; Christophe Clément; Ian Crozier; Armando Garcia; Steven J. Hoffman; Gordon H. Guyatt

doi:10.1016/s0140-6736(17)31795-6

Evidence-based guidelines for supportive care of patients with Ebola virus disease

François Lamontagne, Robert A. Fowler, Neill K. Adhikari, Srinivas Murthy, David M. Brett-Major, Michael Jacobs, Timothy M. Uyeki, Constanza Vallenas, Susan L. Norris, William A. Fischer, Tom Fletcher, Adam C. Levine, Paul Reed, Daniel G. Bausch, Sandy Gove, Andrew Hall, Susan Shepherd, Reed A. Siemieniuk, Marie Claude Lamah, Rashida KamaraPhiona Nakyeyune, Moses J. Soka, Ama Edwin, Afeez A. Hazzan, Shevin Jacob, Mubarak Mustafa Elkarsany, Takuya Adachi, Lynda Benhadj, Christophe Clément, Ian Crozier, Armando Garcia, Steven J. Hoffman, Gordon H. Guyatt

Clinical Sciences

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Abstract

The 2013-2016 Ebola virus disease (EVD) outbreak in West Africa was associated with unprecedented challenges in the provision of care to EVD patients, including lack of pre-existing isolation and treatment facilities, patients' reluctance to present for medical care due to fear of a high risk of mortality in treatment units, lack of effective Ebola virus-specific therapy and limitations in provision of supportive medical care. Case fatality rates (CFR) in West Africa were initially greater than 70% but over time decreased with increasing clinical and health system experience that included improvements in supportive care. To inform optimal care in a future EVD outbreak, we employed the Grading of Recommendations Assessment, Development and Evaluation (GRADE) methodology to develop evidence-informed guidelines for the delivery of supportive care to patients admitted to Ebola treatment units.

Original language	English
Pages (from-to)	700-708
Number of pages	9
Journal	The Lancet
Volume	391
Issue number	10121
Early online date	17 Oct 2017
DOIs	https://doi.org/10.1016/s0140-6736(17)31795-6
Publication status	Published - 17 Feb 2018

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Lancet Evidence-based guidelines for supportive care of patients with Ebola virus disease acceptedAccepted author manuscript, 144 KBLicence: CC BY-NC-ND

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Lamontagne, F., Fowler, R. A., Adhikari, N. K., Murthy, S., Brett-Major, D. M., Jacobs, M., Uyeki, T. M., Vallenas, C., Norris, S. L., Fischer, W. A., Fletcher, T., Levine, A. C., Reed, P., Bausch, D. G., Gove, S., Hall, A., Shepherd, S., Siemieniuk, R. A., Lamah, M. C., ... Guyatt, G. H. (2018). Evidence-based guidelines for supportive care of patients with Ebola virus disease. The Lancet, 391(10121), 700-708. https://doi.org/10.1016/s0140-6736(17)31795-6

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title = "Evidence-based guidelines for supportive care of patients with Ebola virus disease",

abstract = "The 2013-2016 Ebola virus disease (EVD) outbreak in West Africa was associated with unprecedented challenges in the provision of care to EVD patients, including lack of pre-existing isolation and treatment facilities, patients' reluctance to present for medical care due to fear of a high risk of mortality in treatment units, lack of effective Ebola virus-specific therapy and limitations in provision of supportive medical care. Case fatality rates (CFR) in West Africa were initially greater than 70\% but over time decreased with increasing clinical and health system experience that included improvements in supportive care. To inform optimal care in a future EVD outbreak, we employed the Grading of Recommendations Assessment, Development and Evaluation (GRADE) methodology to develop evidence-informed guidelines for the delivery of supportive care to patients admitted to Ebola treatment units.",

author = "Fran{\c c}ois Lamontagne and Fowler, \{Robert A.\} and Adhikari, \{Neill K.\} and Srinivas Murthy and Brett-Major, \{David M.\} and Michael Jacobs and Uyeki, \{Timothy M.\} and Constanza Vallenas and Norris, \{Susan L.\} and Fischer, \{William A.\} and Tom Fletcher and Levine, \{Adam C.\} and Paul Reed and Bausch, \{Daniel G.\} and Sandy Gove and Andrew Hall and Susan Shepherd and Siemieniuk, \{Reed A.\} and Lamah, \{Marie Claude\} and Rashida Kamara and Phiona Nakyeyune and Soka, \{Moses J.\} and Ama Edwin and Hazzan, \{Afeez A.\} and Shevin Jacob and Elkarsany, \{Mubarak Mustafa\} and Takuya Adachi and Lynda Benhadj and Christophe Cl{\'e}ment and Ian Crozier and Armando Garcia and Hoffman, \{Steven J.\} and Guyatt, \{Gordon H.\}",

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Lamontagne, F, Fowler, RA, Adhikari, NK, Murthy, S, Brett-Major, DM, Jacobs, M, Uyeki, TM, Vallenas, C, Norris, SL, Fischer, WA, Fletcher, T, Levine, AC, Reed, P, Bausch, DG, Gove, S, Hall, A, Shepherd, S, Siemieniuk, RA, Lamah, MC, Kamara, R, Nakyeyune, P, Soka, MJ, Edwin, A, Hazzan, AA, Jacob, S, Elkarsany, MM, Adachi, T, Benhadj, L, Clément, C, Crozier, I, Garcia, A, Hoffman, SJ & Guyatt, GH 2018, 'Evidence-based guidelines for supportive care of patients with Ebola virus disease', The Lancet, vol. 391, no. 10121, pp. 700-708. https://doi.org/10.1016/s0140-6736(17)31795-6

TY - JOUR

T1 - Evidence-based guidelines for supportive care of patients with Ebola virus disease

AU - Lamontagne, François

AU - Fowler, Robert A.

AU - Adhikari, Neill K.

AU - Murthy, Srinivas

AU - Brett-Major, David M.

AU - Jacobs, Michael

AU - Uyeki, Timothy M.

AU - Vallenas, Constanza

AU - Norris, Susan L.

AU - Fischer, William A.

AU - Fletcher, Tom

AU - Levine, Adam C.

AU - Reed, Paul

AU - Bausch, Daniel G.

AU - Gove, Sandy

AU - Hall, Andrew

AU - Shepherd, Susan

AU - Siemieniuk, Reed A.

AU - Lamah, Marie Claude

AU - Kamara, Rashida

AU - Nakyeyune, Phiona

AU - Soka, Moses J.

AU - Edwin, Ama

AU - Hazzan, Afeez A.

AU - Jacob, Shevin

AU - Elkarsany, Mubarak Mustafa

AU - Adachi, Takuya

AU - Benhadj, Lynda

AU - Clément, Christophe

AU - Crozier, Ian

AU - Garcia, Armando

AU - Hoffman, Steven J.

AU - Guyatt, Gordon H.

PY - 2018/2/17

Y1 - 2018/2/17

N2 - The 2013-2016 Ebola virus disease (EVD) outbreak in West Africa was associated with unprecedented challenges in the provision of care to EVD patients, including lack of pre-existing isolation and treatment facilities, patients' reluctance to present for medical care due to fear of a high risk of mortality in treatment units, lack of effective Ebola virus-specific therapy and limitations in provision of supportive medical care. Case fatality rates (CFR) in West Africa were initially greater than 70% but over time decreased with increasing clinical and health system experience that included improvements in supportive care. To inform optimal care in a future EVD outbreak, we employed the Grading of Recommendations Assessment, Development and Evaluation (GRADE) methodology to develop evidence-informed guidelines for the delivery of supportive care to patients admitted to Ebola treatment units.

AB - The 2013-2016 Ebola virus disease (EVD) outbreak in West Africa was associated with unprecedented challenges in the provision of care to EVD patients, including lack of pre-existing isolation and treatment facilities, patients' reluctance to present for medical care due to fear of a high risk of mortality in treatment units, lack of effective Ebola virus-specific therapy and limitations in provision of supportive medical care. Case fatality rates (CFR) in West Africa were initially greater than 70% but over time decreased with increasing clinical and health system experience that included improvements in supportive care. To inform optimal care in a future EVD outbreak, we employed the Grading of Recommendations Assessment, Development and Evaluation (GRADE) methodology to develop evidence-informed guidelines for the delivery of supportive care to patients admitted to Ebola treatment units.

U2 - 10.1016/s0140-6736(17)31795-6

DO - 10.1016/s0140-6736(17)31795-6

M3 - Article

SN - 0140-6736

VL - 391

SP - 700

EP - 708

JO - The Lancet

JF - The Lancet

IS - 10121

ER -

Evidence-based guidelines for supportive care of patients with Ebola virus disease

Abstract

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