Evaluation of a special low birth weight formula, with and without the use of medium chain triacylglycerols

A special low birth weight formula containing 1.8 g/100 ml of medium chain triacylglycerols (Nenatal) was compared with 'modified' Nenatal (medium chain triacylglycerols (MCT) replaced by long chain triacylglycerols (LCT)) and standard modified baby milk (Cow and Gate Premium). 22 infants of birth weight less than 1500 g and gestational age less than 33 weeks were studied for three weeks when enteral feeds were well tolerated. Nenatal was given to all infants for the first and third weeks, during the middle week 11 infants received Premium and 11 infants received modified Nenatal. On Nenatal there was a significant elevation of serum β-hydroxybutyrate and small amounts of medium chain fatty acids were detected in the serum. Glucose and long chain triacylglycerol levels were similar on all feeds. Incremental weight gain and energetic efficiency of weight gain was significantly greater on Nenatal than on Premium, but there was no difference in this respect between Nenatal and modified Nenatal. We conclude that the use of a special low birth weight formula is associated with increased weight gain, but this is not dependent on the presence of MCT in the feed. Therefore although feeds containing MCT are well tolerated, there seems little advantage in including MCT in the formulation of low birth weight feeds.