Erythropoiesis in HIV-infected and uninfected Malawian children with severe anemia.

Job C.J. Calis; Kamija S. Phiri; Raymond J.W.M. Vet; Rob J. De Haan; Francis Munthali; Robert J. Kraaijenhagen; Paul J.M. Hulshof; Malcolm E. Molyneux; Bernard J. Brabin; Michaël Boele Van Hensbroek; Imelda Bates

doi:10.1097/qad.0b013e32833fed27

Erythropoiesis in HIV-infected and uninfected Malawian children with severe anemia.

Job C.J. Calis, Kamija S. Phiri, Raymond J.W.M. Vet, Rob J. De Haan, Francis Munthali, Robert J. Kraaijenhagen, Paul J.M. Hulshof, Malcolm E. Molyneux, Bernard J. Brabin, Michaël Boele Van Hensbroek, Imelda Bates

International Public Health

Research output: Contribution to journal › Article › peer-review

13 Citations (Scopus)

Abstract

Anemia is common in HIV infection, but the pathophysiology is poorly understood. Bone marrow analysis in 329 severely anemic (hemoglobin <5 g/dl) Malawian children with (n = 40) and without (n = 289) HIV infection showed that HIV-infected children had fewer CD34(+) hematopoietic progenitors (median 10 vs. 15‰, P = 0.04) and erythroid progenitors (2.2 vs. 3.4‰, P = 0.05), but there were no differences in erythrocyte viability and maturation in later stages of erythropoiesis. Despite an HIV-associated reduction in early red cell precursors, subsequent erythropoiesis appears to proceed similarly in HIV-infected and HIV-uninfected children with severe anemia.

Original language	English
Pages (from-to)	2883-2887
Number of pages	5
Journal	AIDS
Volume	24
Issue number	18
DOIs	https://doi.org/10.1097/qad.0b013e32833fed27
Publication status	Published - 27 Nov 2010

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1097/qad.0b013e32833fed27

Cite this

@article{364fd06a29694b1a8b1d837a112467d2,

title = "Erythropoiesis in HIV-infected and uninfected Malawian children with severe anemia.",

abstract = "Anemia is common in HIV infection, but the pathophysiology is poorly understood. Bone marrow analysis in 329 severely anemic (hemoglobin <5 g/dl) Malawian children with (n = 40) and without (n = 289) HIV infection showed that HIV-infected children had fewer CD34(+) hematopoietic progenitors (median 10 vs. 15‰, P = 0.04) and erythroid progenitors (2.2 vs. 3.4‰, P = 0.05), but there were no differences in erythrocyte viability and maturation in later stages of erythropoiesis. Despite an HIV-associated reduction in early red cell precursors, subsequent erythropoiesis appears to proceed similarly in HIV-infected and HIV-uninfected children with severe anemia.",

author = "Calis, \{Job C.J.\} and Phiri, \{Kamija S.\} and Vet, \{Raymond J.W.M.\} and \{De Haan\}, \{Rob J.\} and Francis Munthali and Kraaijenhagen, \{Robert J.\} and Hulshof, \{Paul J.M.\} and Molyneux, \{Malcolm E.\} and Brabin, \{Bernard J.\} and \{Van Hensbroek\}, \{Micha{\"e}l Boele\} and Imelda Bates",

year = "2010",

month = nov,

day = "27",

doi = "10.1097/qad.0b013e32833fed27",

language = "English",

volume = "24",

pages = "2883--2887",

journal = "AIDS",

issn = "0269-9370",

publisher = "Lippincott Williams and Wilkins",

number = "18",

}

TY - JOUR

T1 - Erythropoiesis in HIV-infected and uninfected Malawian children with severe anemia.

AU - Calis, Job C.J.

AU - Phiri, Kamija S.

AU - Vet, Raymond J.W.M.

AU - De Haan, Rob J.

AU - Munthali, Francis

AU - Kraaijenhagen, Robert J.

AU - Hulshof, Paul J.M.

AU - Molyneux, Malcolm E.

AU - Brabin, Bernard J.

AU - Van Hensbroek, Michaël Boele

AU - Bates, Imelda

PY - 2010/11/27

Y1 - 2010/11/27

N2 - Anemia is common in HIV infection, but the pathophysiology is poorly understood. Bone marrow analysis in 329 severely anemic (hemoglobin <5 g/dl) Malawian children with (n = 40) and without (n = 289) HIV infection showed that HIV-infected children had fewer CD34(+) hematopoietic progenitors (median 10 vs. 15‰, P = 0.04) and erythroid progenitors (2.2 vs. 3.4‰, P = 0.05), but there were no differences in erythrocyte viability and maturation in later stages of erythropoiesis. Despite an HIV-associated reduction in early red cell precursors, subsequent erythropoiesis appears to proceed similarly in HIV-infected and HIV-uninfected children with severe anemia.

AB - Anemia is common in HIV infection, but the pathophysiology is poorly understood. Bone marrow analysis in 329 severely anemic (hemoglobin <5 g/dl) Malawian children with (n = 40) and without (n = 289) HIV infection showed that HIV-infected children had fewer CD34(+) hematopoietic progenitors (median 10 vs. 15‰, P = 0.04) and erythroid progenitors (2.2 vs. 3.4‰, P = 0.05), but there were no differences in erythrocyte viability and maturation in later stages of erythropoiesis. Despite an HIV-associated reduction in early red cell precursors, subsequent erythropoiesis appears to proceed similarly in HIV-infected and HIV-uninfected children with severe anemia.

U2 - 10.1097/qad.0b013e32833fed27

DO - 10.1097/qad.0b013e32833fed27

M3 - Article

SN - 0269-9370

VL - 24

SP - 2883

EP - 2887

JO - AIDS

JF - AIDS

IS - 18

ER -

Erythropoiesis in HIV-infected and uninfected Malawian children with severe anemia.

Abstract

UN SDGs

Access to Document

Fingerprint

Cite this